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Diss Factsheets
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EC number: 233-245-9 | CAS number: 10099-74-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No GLP, relatively poor documentation
Data source
Reference
- Reference Type:
- publication
- Title:
- Single oral toxicity of various organic compounds
- Author:
- Kinkead E.D., Wolfe R.E
- Year:
- 1 992
- Bibliographic source:
- Journal of the American College of Toxicology; 1992; 11:713
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Lead acetate
- EC Number:
- 239-379-4
- EC Name:
- Lead acetate
- Cas Number:
- 15347-57-6
- IUPAC Name:
- lead(4+) tetraacetate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- no details
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- no details
- Doses:
- 2500, 5000, 6300, 7940, 10000
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
Results and discussion
Any other information on results incl. tables
Five male and five female Sprague-Dawley rats were used per dose level. Water soluble compounds were administered in distilled water. Compounds that would not dissolve in water were administered as suspensions in corn oil. All rats were fasted prior to dosing and the gavage volume was maintained: at 0.01 mL/g body weight. All survivors were maintained for a 14-day observation period.
Geometrically spaced doses were administered to determine the LD50. Calculations were by moving average interpolation method of Weil, Biometrics 1952(8) 249-263.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- For lead acetate LD50 values of 4665 (3153 -6900) and 5610 mg/kg bw have been observed for male and female rats, respectively. It is reasonable to assume that the toxicity of lead salts is triggered by the lead cation and not the corresponding anion. Therefore, it is considered justified to use data from lead acetate also for other soluble lead salts like lead dinitrate. As the molar mass of lead acetate and lead dinitrate is almost identical the LD50 value for lead acetate is also applicable for lead dinitrate.
- Executive summary:
Five male and five female Sprague-Dawley rats were used per dose level. Lead acetate was administered in distilled water. All rats were fasted prior to dosing and the gavage volume was maintained: at 0.01 mL/g body weight. All survivors were maintained for a 14 -day observation period.
Geometrically spaced doses were administered to determine the LD50. Calculations were by moving average interpolation method of Weil, Biometrics 1952(8) 249-263.
For lead acetate LD50 values of 4665 (3153 -6900) and 5610 mg/kg bw have been observed for male and female rats, respectively.
It is reasonable to assume that the toxicity of lead salts is triggered by the lead cation and not the corresponding anion. Therefore, it is considered justified to use data from lead acetate also for other soluble lead salts like lead dinitrate. As the molar mass of lead acetate and lead dinitrate is almost identical the LD50 value for lead acetate is also applicable for lead dinitrate.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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