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EC number: 920-750-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 3 - 23 September 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study. Only single test concentration used.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Hydrocarbons, C7-C9, n-alkanes, isoalkanes, cyclics
- EC Number:
- 920-750-0
- Cas Number:
- none available
- Molecular formula:
- None available - not a single isomer - see remarks
- IUPAC Name:
- Hydrocarbons, C7-C9, n-alkanes, isoalkanes, cyclics
- Details on test material:
- - Name of test material (as cited in study report): SBP 100/140. A mixture of hydrocarbon liquids. SICC code: Q 5811
- Substance type: colourless liquid
- Physical state: liquid
- Analytical purity: 100% pure commercial product
- Stability under test conditions: yes
- Storage condition of test material: room temperature in original container
- Other: supplied by sponsor
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Interfauna UK Ltd., Abbots Ripton Road, Wyton, Huntingdon
- Age at study initiation: 6 weeks (male), 8 weeks (female), different ages selected so that both sexes are of same body weight
- Weight at study initiation: 200 g
- Housing: polypropylene cages (38 x 56 x 18 cm) with wire meshes on tops and floors
- Diet (e.g. ad libitum): measured excess amount of food (Labsure LAD 1)
- Water (e.g. ad libitum): measured excess amount of tap water
ENVIRONMENTAL CONDITIONS
- Temperature (°C): mean daily maximum: 25°C (SD 1.3), mean daily minimum: 21°C (SD 0.6)
- Humidity (%): mean relative humidity: 60% (SD 6.4)
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: all parts were made of perspex
- Exposure chamber volume: 120 liters
- Method of holding animals in test chamber: Chamber divided by wire mesh partitions to provide 10 seperate animal compartments
- Source and rate of air: flow rate fo 25 L per minute; air warmed to 30°C to assist vaporisation of test substance. For the exposure a 50 mL syringe filled with the test substance was fitted to the syringe pump and connected to the atomiser with PTFE tubing. A flow rate of approx. 0.9 mL per minute was selected for the exposure. This flow rate was expected to give a concentration of vapour in excess of 20 mg/L of air. The syringe pump was switched on and the exposure timed for 4 hours, following an 11-minute equilibration period (total exposure time 4 hours 11 minutes). The syringe was refilled as required during the exposure.
- Method of conditioning air: The compressed air supply to the generator was dried, filtered and oil-free
- Temperature, humidity, pressure in air chamber: mean of 25.4°C in control and test
TEST ATMOSPHERE
- Brief description of analytical method used: 5 air samples were taken from the chamber during each exposure and analysed to determine the concentration of the test substance in the chamber atmosphere. The samples were drawn through a gas absorption trap, containing approximately 20 mL of acetone and cooled to -70°C in acetone/dry ice(=refrigerant). The sampling rate was 2 liters per minute and the volume of air sample was measured with a wet-type gas meter. One additional sample was taken using a Royco 218 particle size analyser to confirm the absence of droplets. - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- GLC
- Duration of exposure:
- 4 h
- Concentrations:
- mean of 23.3 mg/L of air
- No. of animals per sex per dose:
- 5 males, 5 females
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observed continuously during exposure and at least twice daily during observation period. Weighed daily from the day of delivery to the end of the observation period
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 23.3 mg/L air
- Exp. duration:
- 4 h
- Mortality:
- One male died during exposure at approximately 2 hours from the start of exposure
- Clinical signs:
- other: Partial closing of the eyes, restless behaviour and a reduced respiration rate were the main clinical signs evident during exposure. The signs were considered to be consistent with exposure to a slightly irritant vapour. Other signs seen during exposure w
- Body weight:
- All rats exposed lost weight or had a reduced rate of bodyweight gain for 1-2 days following exposure. Subsequently the rate of bodyweight gain for exposed rats was similar to that of the control rats.
- Gross pathology:
- Findings for the rat that died following exposure were congestion of the lungs, yellow frothy fluid in the trachea and gas-filled stomach and gastro-intestinal tract
- Other findings:
- Food consumption was reduced for 1 day following exposure. Water consumption was not affected.
Histopathology: Marked pulmonary congestion and focal alveolar haemorrhage in the single deceased rat. Significance of this finding is uncertain.
Any other information on results incl. tables
Table: Mean Bodyweights (g)
Day |
Female Control |
Female Test |
Male Control |
Male Test |
-5 |
174 |
179 |
153 |
148 |
-4 |
183 |
186 |
164 |
164 |
-3 |
189 |
185 |
172 |
176 |
-2 |
194 |
191 |
187 |
194 |
-1 |
198 |
197 |
196 |
201 |
0 |
203 |
202 |
203 |
211 |
1 |
203 |
199 |
211 |
212 |
2 |
205 |
201 |
222 |
219 |
3 |
213 |
211 |
229 |
232 |
4 |
214 |
212 |
237 |
242 |
5 |
216 |
209 |
240 |
249 |
6 |
219 |
211 |
248 |
255 |
7 |
221 |
212 |
259 |
264 |
8 |
228 |
215 |
273 |
282 |
9 |
230 |
226 |
276 |
285 |
10 |
234 |
227 |
285 |
295 |
11 |
242 |
234 |
297 |
307 |
12 |
242 |
238 |
300 |
315 |
13 |
244 |
238 |
303 |
319 |
14 |
246 |
239 |
308 |
324 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: GHS, EU, 2007
- Conclusions:
- The purpose of the is study was to examine the inhalation toxicity of hydrocarbons, C7-C9, n-alkanes, isoalkanes, cyclics to rats. 5 male and 5 female rats were exposed to a concentration of 23.3 mg/L of test substance in the air for 4 hrs. Animals were examined at 0, 0.25, 0.5, 1, 2, 3, and 4 hrs after start of exposure for clinical signs and mortality. Animals were also examined daily for the next 14 days. Animals were weighed daily. Animals were examined for gross pathology and histopathology either after death, or after sacrifice at the end of the experiment. One male rat died during the experiment. The LC50 is > 23.3 mg/L of air. The test substance is not classified as toxic under the OECD GHS guidelines.
- Executive summary:
The purpose of the is study was to examine the inhalation toxicity of hydrocarbons, C7-C9, n-alkanes, isoalkanes, cyclics to rats. 5 male and 5 female rats were exposed to a concentration of 23.3 mg/L of test substance in the air for 4 hrs. Animals were examined at 0, 0.25, 0.5, 1, 2, 3, and 4 hrs after start of exposure for clinical signs and mortality. Animals were also examined daily for the next 14 days. Animals were weighed daily. Animals were examined for gross pathology and histopathology either after death, or after sacrifice at the end of the experiment. One male rat died during the experiment. The LC50 is > 23.3 mg/L of air. The test substance is not classified as toxic under the OECD GHS guidelines.
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