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EC number: 245-366-4 | CAS number: 22984-54-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11 Mar 1986 to 22 Jan 1987
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- (No information on test substance purity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Butan-2-one O,O',O''-(methylsilylidyne)trioxime
- EC Number:
- 245-366-4
- EC Name:
- Butan-2-one O,O',O''-(methylsilylidyne)trioxime
- Cas Number:
- 22984-54-9
- Molecular formula:
- C13H27N3O3Si
- IUPAC Name:
- butan-2-one O,O',O''-(methylsilanetriyl)oxime
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): SILANE 196 - Méthyltris (méthyléthylcétiminoxy) silane
- Substance type: Ketoxime
- Physical state: Liquid
- Storage condition of test material: Minimum of 19°C.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Iffa-Credo,France.
- Age at study initiation: 5-7 weeks
- Weight at study initiation: Males: 158-163 g; Females: 138-151 g
- Fasting period before study: Yes
- Housing: groups of five in stainless steel mesh cages.
- Diet: Pelleted complete maintenance diet (UAR, formula "A.D4", UAR, Epinay sur Orge, France), ad libitum
- Water: Softened and filtered drinking water, ad libitum
- Acclimation period: Minimum one week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22±3
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 03.11.1986 To: 17.12.1986
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 2.85 ml/kg
- Doses:
- 1129, 1416, 1782, 2247 (two groups), 2822 mg/kg bw
- No. of animals per sex per dose:
- Five
- Control animals:
- other: yes, distilled water
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Mortality and abnormal clinical signs were noted 15 minutes after administration of the test substance, then 1, 2 and 4 hours later and then 14 day recovery period. Body weights were measured on Day -1, Day 1 (immediately before administration), Day 8 and 15.
- Necropsy of survivors performed: yes (and of animals that died).
- Other examinations performed: gross pathology. - Statistics:
- The body weight of the animals was evaluated, for each group and each sex, by calculating the mean values, the standard variation and the coefficient of variation to give a statistical appreciation of the homogeneity of the data, and whenever possible, by the Student test to compare each treated group with the control group. The gradient of the mortality curve at the different dose levels enabled an LD50 to be calculated.
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 463 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Method of Bliss. The report is not entirely clear, however the upper and lower limits appear to be 95% CL.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 453 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Method of Litchfield & Wilcoxon. The report is not entirely clear, however the upper and lower limits appear to be 95% CL.
- Mortality:
- See Table 1.
- Clinical signs:
- other: See Table 1.
- Gross pathology:
- Discolouration of the spleen.
Any other information on results incl. tables
Table 1: Number of animals that died, time range for mortality, body weight change and overt toxicity.
Dose |
Mortality (dead/total) |
Time range of deaths (days) |
Overt toxicity (numbers affected, where specified in the report) |
||
Male |
Female |
Combined |
|
||
0 |
0/0 |
0/0 |
0/10 |
- |
- |
1129 |
0/0 |
0/0 |
0/10 |
- |
Prostration, lethargy, coma (2), piloerection(10), ptosis(4), ataxia. No overt adverse effects on day 2. |
1416 |
0/0 |
0/0 |
0/10 |
- |
Prostration, lethargy, coma (3), piloerection(10), ptosis(5), ataxia. No overt adverse effects on day 2. |
1782 |
2/5 |
0/5 |
2/10- |
2 |
Prostration, lethargy, coma (6), piloerection(10), ptosis(3), ataxia. No overt adverse effects in surviving animals on day 2. |
2247 |
2/5 |
2/5 |
4/10 |
2 |
Prostration, lethargy, coma (6), piloerection(10), ptosis(4), ataxia. No overt adverse effects on day 3. |
2247 |
2/5 |
1/5 |
3/10 |
2 |
Prostration, lethargy, coma (7), piloerection(10). No overt adverse effects in surviving animals on day 3. |
2822 |
4/5 |
3/5 |
7/10 |
2 |
Either prostration, lethargy or coma (8) in all animals. Some cases of piloerection, lacrimation, clonic convulsions and ataxia. No overt adverse effects in surviving animals on day 3. |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- CLP Implementation
- Conclusions:
- In an acute oral toxicity study conducted to the now deleted OECD 401 and to GLP (RL 1) the LD50 for butan-2-one O,O',O''-(methylsilylidyne)trioxime was 2463 mg/kg bw in rats. Clinical signs of toxicity at all doses were prostration, lethargy, ptosis, ataxia and coma in several animals. In surviving animals these signs had disappeared by day 2/3.
- Executive summary:
An acute oral toxicity study was conducted according to the OECD guideline 401 under GLP conditions. Five Sprague Dawley rats per sexe were exposed to 1129, 1416, 1782, 2247 (two groups), 2822 mg/kg bw test substance by oral gavage. Control animals were administered distilled water. Mortality and abnormal clinical signs were noted 15 minutes after administration of the test substance, then 1, 2 and 4 hours later and then 14 day recovery period. Body weights were measured on Day -1, Day 1 (immediately before administration), Day 8 and 15. Necropsy was performed at day 15 to survivors and to animals which died. Clinical signs of toxicity at all doses were prostration, lethargy, ptosis, ataxia and coma in several animals. In surviving animals these signs had disappeared by day 2/3, reduced body weight gain was observed at high doses, discolouration of the spleen was observed macroscopically. The oral LD50 was determined as 2463 mg/kg-bw/day.
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