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EC number: 270-299-2 | CAS number: 68424-38-4 This substance is identified by SDA Substance Name: C16-C18 alkyl carboxylic acid sodium salt and SDA Reporting Number: 19-006-04.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Edenor C16 98 - 100, palmitic acid
- IUPAC Name:
- Edenor C16 98 - 100, palmitic acid
- Reference substance name:
- [TN]Fatty acid C 16-18, sodium salt[/TN][SPEC][/SPEC][AM][/AM]
- IUPAC Name:
- [TN]Fatty acid C 16-18, sodium salt[/TN][SPEC][/SPEC][AM][/AM]
- Details on test material:
- no data
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: mean body weight female rats: 137g; mean body weight male rats: 183g
- Fasting period before study: 18 hours
- Diet: ad libitum
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22°C
- Humidity (%): 45-60%
- Photoperiod: 12 hrs dark /12 hrs light
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- DMSO
- Details on oral exposure:
- - Concentration in vehicle: 50%
- Doses:
- 5g test substance/kg body weight
- No. of animals per sex per dose:
- 5 animals per sex and dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: immediately after application, 1, 4 and 24 hours after application, daily thereafter
- Frequency of weighing: immediately before application, 1, 7 and 14 days after application
- Necropsy of survivors performed: yes - Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- One female rat died on day 12.
- Clinical signs:
- other: 20 minutes after treatment, the symptomes of poisoning were strongly ruffled fur and slightly decreased activity. This symptoms subsided completely within 24 hours.
- Gross pathology:
- Apart from a swelling of the gastric mucosa in male and female rats, there were no signs of poisoning.
Any other information on results incl. tables
Mean body weight
Dose |
Gender |
Before application |
24 hours after application |
7 days |
14 days |
5 g/kg |
male |
183.0 |
195.0 |
214.0 |
234.0 |
5 g/kg |
female |
137.0 |
143.0 |
149.0 |
160.0 |
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- The LD50 of Edenor C 16 98-100 is estimated to be higher than 5000 mg/kg body weight in male and female rats for a single dose.
Therefore the test substance Edenor C 16 98-100 is practically nontoxic according to the OECD Guideline 401. - Executive summary:
Aim of the study
It was the aim of the study to investigate acute toxic effects of the test substance after a single oral administration.
Methods
The OECD-Guideline 401, "Acute Oral Toxicity" was applied.
Administration
Edenor C 16 98-100 was administered once oral by stomach intubation to Wistar rats. The dosing was performed sequentially to 5 male and 5 female animals, each using a dose of 5000 mg per kg body weight.
Investigations
Body weight: before administration, 1, 7 and 14 days p.a.
Clinical observations were performed 0, 1, 4, 24 hours p.a. of the test substance and then at least once a day for a total of 2 weeks.
Necropsy: all animals were sacrificed and necropsied 14 days p.a.
Results
Mortality
One female rat died on day 12.
Body weights
Males and females: Body weight and body weight gain of all animals were inconspicuous.
Clinical observations
20 minutes p.a. all animals indicated symptoms of poisoning. All animals showed strongly ruffled fur and slightly decreased activit
Necropsy findings
Apart from a swelling of the gastric mucosa in male and female rats, there were no signs of poisoning
Sex differences
The response to the test substance at 5000 mg/kg body weight did not indicate a sex difference.
The LD50 of Edenor C 16 98-100 is estimated to be higher than 5000 mg/kg body weight in male and female rats for a single dose. Therefore the test substance Edenor C 16 98-100 is practically nontoxic according to the OECD Guideline 401.
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