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Diss Factsheets
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EC number: 204-337-6 | CAS number: 119-61-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation / corrosion
Not irritating in a study performed with rabbits according to OECD Guideline 404 (Kaaber, 1999).
Eye irritation / corrosion
For benzophenone there are no valid studies available performed with experimental animals. In one study (Eastman Kodak Co., 1984; results are limited due to missing details) the application of several crystals of benzophenone into the conjunctival sac caused only a slight reaction. In the other study (Upjohn Co., 1984) the treatment caused no eye irritation. Based on the widespread exposure and the long term experience with benzophenone in humans, it can be concluded that the substance is not a significant eye irritant and negates the need for any further animal testing with respect to this endpoint.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation / corrosion, other
- Remarks:
- in vivo study
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998-1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Scantox, Lille Skensved, Denmark
- Species:
- rabbit
- Strain:
- other: MOL:Russian
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: M&B, Ejby, DK-4623 Lille Skensved, Denmark
- Weight at study initiation: 2.2-2.4 kg
- Housing: individual in PPO/HIPS cages
- Diet : ad libitum
- Water : ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +- 3°C
- Humidity (%): 55 +- 15%
- Air changes (per hr): 10/hour
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From 14 Dec 1998 To: 01 January 1999 - Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- other: Ethanol 96% and Diethyl phthalate (1:1)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g of the test item was moistened with 0.5 mL vehicle, or 0.5 mL of the test article solution (if diluted), were applied
- Concentration (if solution): 2, 5, 10, 25 and 100%
VEHICLE
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 1 hour after exposure period as well as 24, 48 and 72 hours after exposure period
- Number of animals:
- 4
- Details on study design:
- TEST SITE
- Area of exposure: 10x10 cm, 6 sites were selected on this area
- Type of wrap if used: gauze patches secured with 2.5 cm adhesive tapes
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes, with lukewarm water and mild soap
- Time after start of exposure: 4 hours after exposure
SCORING SYSTEM: Erythema and Eschar formation: Score 0 to 4; Oedema formation: Score 0 to 4 - Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Irritant / corrosive response data:
- No signs of irritations were observed at any of the concentrations tested
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- All treated skin sites were scored with 0, i.e. no irritation was induced at any of the tested concentrations. Benzophenone is therefore not subject of classification.
- Executive summary:
A primary skin irritation study was performed in rabbits according to OECD 404 (1992). Benzophenone was tested at concentrations of 2, 5, 10, 25 and 100%. No signs of skin irritation were observed at any of the concentrations tested. Therefore, no classification as skin irritant is required.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation, other
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Justification for type of information:
- For benzophenone there are no valid studies available performed with experimental animals. In one study (results are limited due to missing details) the application of several crystals of benzophenone into the conjunctival sac caused only a slight reaction. In the other study the treatment caused no eye irritation. Based on the widespread exposure and the long term experience with benzophenone in humans, it can be concluded that the substance is not a significant eye irritant and negates the need for any further animal testing with respect to this endpoint.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation / corrosion
A primary skin irritation study was performed in rabbits according to OECD 404 (Kaaber, 1999). Benzophenone was tested at concentrations of 2, 5, 10, 25 and 100%. All treated skin sites were scored with 0, i.e. no irritation was induced at any of the tested concentrations.
Eye irritation / corrosion
For benzophenone there are no valid studies available performed with experimental animals. In one study (Eastman Kodak Co., 1984; results are limited due to missing details) the application of several crystals of benzophenone into the conjunctival sac caused only a slight reaction. In the other study (Upjohn Co., 1984) the treatment caused no eye irritation. Based on the widespread exposure and the long term experience with benzophenone in humans, it can be concluded that the substance is not a significant eye irritant and negates the need for any further animal testing with respect to this endpoint.
Respiratory irritation
No data available.
Justification for classification or non-classification
Skin irritation / corrosion
Based on the data provided by Kaaber (1999), there is no need for a classification according to the criteria of EC Directive 1272/2008 and of the GHS.
Eye irritation / corrosion
For benzophenone there are no valid studies available performed with experimental animals. Based on the widespread exposure and the long term experience with benzophenone in humans, it can be concluded that the substance is not a significant eye irritant, i.e. there is no need for a classification according to the criteria of EC Directive 1272/2008 and of the GHS, and negates the need for any further animal testing with respect to this endpoint.
Respiratory irritation
Classification not possible due to lack of data. However, based on the widespread exposure and the long term experience with benzophenone in humans, it can be concluded that the substance is not a significant respiratory irritant, i.e. there is no need for a classification according to the criteria of EC Directive 1272/2008 and of the GHS.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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