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Diss Factsheets
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EC number: 204-464-7 | CAS number: 121-32-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- The summary of the study available is well described. No information on the substance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- intraperitoneal toxicity, Trevan method.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 3-ethoxy-4-hydroxybenzaldehyde
- EC Number:
- 204-464-7
- EC Name:
- 3-ethoxy-4-hydroxybenzaldehyde
- Cas Number:
- 121-32-4
- Molecular formula:
- C9H10O3
- IUPAC Name:
- 3-ethoxy-4-hydroxybenzaldehyde
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: 230.9 to 277.3 g for males and 200.1 to 213 g for females.
- Fasting period before study: an overnight
- Housing: individually in elevated wire-mesh cages
- Diet (e.g. ad libitum): Commercial rodent ration, ad libidum
- Water (e.g. ad libitum): tap water, ad libitum.
- Acclimation period: 1 week before the start of the study.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 to 22.2°C
- Humidity (%): 42-79%
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12h / 12h
IN-LIFE DATES: no data
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: corn oil
- Doses:
- 0; 541; 730; 1000; 1360; 1850 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations: All of the animals were observed for signs of toxic and pharmacologic effects at 1, 3, and 6 hours postdose, and once daily thereafter for fourteen consecutive days.
Weight: Individual body weights were recorded immediately prior to treatment, on Day 14, or at death.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: gross pathology.
- Mortality/moribundity was recorded twice daily. - Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 185 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 1 061 - < 1 310
- Remarks on result:
- other: Calculated LD50 males: 1212 mg/kg (95%CL: 1003-1464 mg/kg bw) Calculated LD50 females: 1131 mg/kg (95%CL: 939- 361 mg/kg bw)
- Mortality:
- - 541 mg/kg: clinical signs, a variety of commonly noted clinical signs was observed in groups 1-4 with severity increasing with dose.
- 730 mg/kg: clinical signs, lethal, 1 female died on day 12 after dosing.
- 1000 mg/kg: clinical signs
- 1360 mg/kg: clinical signs, lethal, micropathology in organs other than list, 5 females and 3 males died at 1 hour to 9 days following dosing.
- 1850 mg/kg: lethal, five females and four males died one hour after dosing. 1 male died 3 hours after dosing. - Other findings:
- Observations frequently noted in some or all of the rats surviving to termination involved the abdominal cavity (abnormal contents), white chunky material adhered to all organs), involved the lung, liver, kidneys, pancreas, and adrenals (discolored); and the stomach, intestines and abdominal cavity (abnormal contents).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.