Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 926-605-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- June 11, 1996
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well conducted study.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 40 CFR 795.226
- Principles of method if other than guideline:
- HEADME
Dermal absorption - GLP compliance:
- not specified
Test material
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- (14C)Cyclohexane
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- dermal, 6 hrs
- Doses:
- 1 and 100 mg/cm2
- No. of animals per group:
- 4/sex
- Control animals:
- no
Results and discussion
Applicant's summary and conclusion
- Executive summary:
Cyclohexane was rapidly excreted after dermal administration. Expired breath was the major route of excretion of radiolabels accounting for ca. 78% of the excreted radiolabel at 1 mg/cm2 and ca 57% of the excreted radiolabel at 100 mg/cm2. Urine was a lesser route of excretion of radiolabel, accounting for ca. 20% at 1 mg/cm2 and ca. 40% at 100 mg/cm2. Essentially no radiolabel was excreted in the feces following dermal administration. The areas under concentration of total radiolabel in blood vs. time curves were ca. 3 times greater at 1 mg/cm2 and ca. 2 times greater at 100 mg/cm2 for females than males. Less than 0.1% and less than 0.4% of the dose of cyclohexane at 100 and 1 mg/cm2, respectively, remained in the carcass 72 hours after dermal exposure. Thus, neither cyclohexane nor its metabolites would be expected to accumulate after repeated exposure to cyclohexane.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Mimo że ECHA udostępnia wiele materiałów online w Twoim języku, część tej strony jest dostępna tylko w języku angielskim. Więcej o praktykach ECHA związanych z mwielojęzycznością.
Witamy na stronie internetowej ECHA. Strona ta nie jest w pełni obsługiwana przez Internet Explorer 7 (i wcześniejsze wersje). Prosimy o zainstalowanie nowszej wersji Internet Explorer.
Niniejsza strona używa plików cookies, aby zapewnić optymalne korzystanie z naszych stron internetowych.
Dodatkowe informacje: jak używamy plików cookies.