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Diss Factsheets
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EC number: 232-164-6 | CAS number: 7789-41-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Calcium bromide
- EC Number:
- 232-164-6
- EC Name:
- Calcium bromide
- Cas Number:
- 7789-41-5
- Molecular formula:
- CaBr2
- IUPAC Name:
- calcium bromide
- Details on test material:
- White powder, stored at room temperature over silica gel.
For the purpose of this study the test material was used as supplied.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- The animals were individually housed in a suspended metal cages. Free access to mains drinking water and food was allowed throughout the study. The animal room was maintained at a temperature of 17-21C and relative humidity of 56-65%. The rate of air exchange was approximately 15 changes per hour and the lightning was controlled by a time switch to give 12 hours light and 12 hours darkness.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped using veterinary clippers
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- 0.5 g of calcium bromide moistened in 0.5ml of water
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 1, 24, 48 and 72 hours and 7 days
- Number of animals:
- 3
- Details on study design:
- No further details
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Score:
- 2.5
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 24h
- Score:
- 2
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 48h
- Score:
- 2
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 72h
- Score:
- 2
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 24h
- Score:
- 2
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 48 h
- Score:
- 1
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 72h
- Score:
- 1
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 24h
- Score:
- 1
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 48h
- Score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 72h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 24h
- Score:
- 1
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 48h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 72h
- Score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: 24h
- Score:
- 2
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: 48h
- Score:
- 1
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: 72h
- Score:
- 1
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: 24h
- Score:
- 2
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: 48h
- Score:
- 1
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: 72h
- Score:
- 1
- Irritant / corrosive response data:
- Very slight to well-defined erythema was noted at all treated skin sites 1 hour after patch removal and at the 24h observation. Very slight or well-defined erythema was also noted at two treated skin sites at the 48 and 720hour observations.
Slight oedema was noted at all treated skin sites 1 hour after patch removal with very slight to slight oedema at the 24-hour observation. Very slight oedema persisted at two treated skin sites at the r48 and 72-hours observations.
Crust formation was confined to one treated skin site at the 7-day observation. This was considered to be reversible reaction.
A small area of possible dermal necrosis was noted along the edge of two treatment sites and developed into a hardened dark brown-coloured scab. This reaction was considered to have been caused by the surgical adhesive tape in contact with the test material. - Other effects:
- No further details
Any other information on results incl. tables
No further details
Applicant's summary and conclusion
- Interpretation of results:
- moderately irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test material, calcium bromide, produced a primary irritation index of 2.5 and was classified as a moderate irritant to rabbit skin according to the Draize classification scheme. No corrosive effects were noted.
The test material did not meet the criteria for classification as irritant or corrosive according to EU labeling regulations. No symbol and risk phrase are required.
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