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Diss Factsheets
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EC number: 214-317-9 | CAS number: 1120-71-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1964
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- INITIAL SUBMISSION: TOXICITY STUDIES OF 1,2-OXATHIOLANE,2,2-DIOXIDE WITH COVER LETTER DATED 09/01/92
- Author:
- OTS
- Year:
- 1 992
- Bibliographic source:
- Microfiche No. OTS0555330 , Doc ID 88-920009014
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- One drop of the undiluted substance was instillated in the eye of one rabbit.
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,3-propanesultone
- EC Number:
- 214-317-9
- EC Name:
- 1,3-propanesultone
- Cas Number:
- 1120-71-4
- Molecular formula:
- C3H6O3S
- IUPAC Name:
- 1,2λ⁶-oxathiolane-2,2-dione
- Details on test material:
- no data
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 1 drop
- Duration of treatment / exposure:
- - single application
- Observation period (in vivo):
- The animals were observed at 1 h, 24 h, 48 h and up to 14 days afterwards.
- Number of animals or in vitro replicates:
- no data
- Details on study design:
- One drop of the undiluted substance was instillated in the eye of one rabbit.
Results and discussion
In vivo
Resultsopen allclose all
- Remarks on result:
- other: No scores given in the publication.
- Remarks:
- Slight to severe erythema and edema of conjunctiva, lids and nicitating membrane as well as opaque cornea, staining and discharge were observed initially, at the 1, 24 and/or 48 hours reading. At the end of the 14-day observation period slight erythema and opaque cornea was still present.
- Irritation parameter:
- cornea opacity score
- Time point:
- 24/48/72 h
- Remarks on result:
- other: No scores given in the publication.
- Irritation parameter:
- iris score
- Time point:
- 24/48/72 h
- Remarks on result:
- other: No scores given in the publication.
- Irritation parameter:
- conjunctivae score
- Time point:
- 24/48/72 h
- Remarks on result:
- other: No scores given in the publication.
- Irritation parameter:
- chemosis score
- Time point:
- 24/48/72 h
- Remarks on result:
- other: No scores given in the publication.
Any other information on results incl. tables
The following symptoms were recorded and presented in the study report on respective time points after instillation of 1 drop in the rabbits eye:
"Initial: Erythema with slight blinking , rubbing with paw or eye held closed.
1 hour: Slight to moderate erythema of conjunctiva, lids and nicitating membrane - as well as moderate to severe edema of the same.
24 hours: Gross edema and erythema throughout, cornea opaque, purulent descharge, staining throughout.
48 hours: Erythema reduced to moderate, edema as before, purulent discharge.
14 days: Edema reduced completely, erythema only slight, cornea opaque."
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- CLP: Eye Damage 1, H318
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