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EC number: 281-161-6 | CAS number: 83877-91-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Testing is not scientifically justified as this substance is hydrolytically unstable. The long-term toxicity 21-d EC50 (reproduction) exists only for the other decomposition product (2-methylpropanol), and this value was used as a key value.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 4 mg/L
Additional information
The short-term key study on acute toxicity to invertebrates performed for this substance identifies that toxicity of this substance is related to the degradation products due to the rapid hydrolysis which takes place immediately after test substance is introduced to water solution. The measured concentration ratio between the degradation products (ethyl acetoacetate and 2 -methylpropanol) was ca. 1.8:1 at the loading rate of 100 mg/l test item. Under the conditions of this study the 48h-EC50 was beyond the range tested.
Because of rapid hydrolysis and low toxicity level at acute daphnia test, testing was considered scientifically unjustified, the toxicity of the degradation products was used in this weight of evidence approach to evaluate the long-term toxicity. One reliable long-term study exists for 2 -methylpropanol but no studies are available for ethyl acetoacetate.
According to Kuehn et al. (1989), the 21-d NOEC(reproduction) of 2 -methylpropan-1-ol to Daphnia magna is 4 mg/l. As there are no reliable results available for ethyl acetoacetate and the target substance this value is used as key value for CSA.
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