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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1995
Report date:
1995

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
no
GLP compliance:
yes
Test type:
standard acute method

Test material

Test animals

Species:
rat
Strain:
other: Alderley Park albino
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Doses:
2000 mg/kg bw
No. of animals per sex per dose:
Five animals per sex and dose
Control animals:
no

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Mortality:
No deaths occurred
Clinical signs:
other: Signs of slight systemic toxicity were observed
Gross pathology:
No treatment related findings were seen

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The substance was not acutely toxic when administered by oral gavage, and the LD50 was >2000 mg/kg bw in the rat.
Executive summary:

The acute oral toxicity of the substance to male and female rats was studied under GLP to principles equivalent to those of the relevant OECD TG. Young adult female and male rats were fasted overnight and then received a single oral dose by gavage of 2000 mg/kg bw in corn oil. The animals were observed over a period of 14 days. No deaths occurred, and only slight signs of systemic toxicity were observed. No treatment related findings were seen during the gross examination post mortem at the scheduled end of the study.