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EC number: 203-308-5 | CAS number: 105-55-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- endocrine system modulation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- Further studies on the chemical nature of compound which inhibit the function of the thyroid gland
- Author:
- Astwood E.B., Bissell A., Hughes A.M.
- Year:
- 1 945
- Bibliographic source:
- Endocrinology, 37: 456-481.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- DETU was tested in rats for capacity to interfere with the endocrine function of the thyroid gland. Each substance was administered to young rats by mixing it with the drinking water in various concentrations. At the end of ten days the thyroid glands were examined grossly and microscopically for evidence of hypertrophy and hyperplasia, and the relative activities of the compounds were then roughly compared on the basis on the minimal dose required to produce a noticeable effect.
- GLP compliance:
- not specified
- Type of method:
- in vivo
Test material
- Reference substance name:
- 1,3-diethyl-2-thiourea
- EC Number:
- 203-308-5
- EC Name:
- 1,3-diethyl-2-thiourea
- Cas Number:
- 105-55-5
- Molecular formula:
- C5H12N2S
- IUPAC Name:
- 1,3-diethyl-2-thiourea
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Source: no data
- Age: "young"
- Weight at study initiation: 40-80 g
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- not specified
- Details on exposure:
- - Test substance was mixed with food.
- Thiouracil was used as a standard of reference and was considered to have an activity of 1. - Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 10 day(s)
- Frequency of treatment:
- in the food
Doses / concentrations
- Remarks:
- Doses / Concentrations:
37 mg/kg of body weight per day
Basis:
- No. of animals per sex per dose:
- 3
- Control animals:
- other: thiouracile as standard of reference
- Details on study design:
- Type: other: Thyroidotoxicity
Observation period: no data
Examinations
- Examinations:
- - Body weight gain: recorded every two days, during the 10-day feeding period (average gain in g per day)
- Total food consumption: globally measured for the 3 animals in order to calculate the average food daily intake per 100g of body weight.
- Organ weight: thyroid glands were weighed at necropsy (in mg per 100g of body weight)
- Biological analysis: thyroid glands of the three rats were pooled and iodine concentration was determined in this pool (in mg per 100 g of fresh tissue).
Results and discussion
- Details on results:
- CONTROL VALUES (Thiouracile):
. Daily body weight gain = 3.6 g
. Thyroid weight = 8.06 mg per 100 g of body weight
. Thyroid iodine concentration = 73.1 mg per 100 g of wet tissue.
RESULTS WITH TEST SUBSTANCE:
. Daily body weight gain = 4.0 g (not significantly different from control values)
. Thyroid weight = 12.1 mg per 100 g of body weight (increased compared to control)
. Thyroid iodine concentration = 3.3 mg per 100 g of wet tissue. Activity was estimated to 0.4 according to thiouracyl values (thiouracyl activity considered as equal to 1). The test substance was found to possess significant antithyroid activity.
Applicant's summary and conclusion
- Conclusions:
- An antithyroid activity of DETU was observed in this study.
- Executive summary:
DETU was tested in rats for capacity to interfere with the endocrine function of the thyroid gland. Test substance was administered to young rats by mixing it with the food at 37 mg/kg bw. At the end of ten days the thyroid glands were examined grossly and microscopically for evidence of hypertrophy and hyperplasia, and the relative activities of the compounds were then roughly compared on the basis on the minimal dose required to produce a noticeable effect.
The weight of thyroid was increased in rat treated with DETU compared to control rats. Thyroid iodine concentration in treated rats was smaller than concentration of control rats. Therefore, an antithyroid activity of DETU was observed in the rats treated with DETU compared to the control rats (treated with thiouracil).
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