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EC number: 246-896-9 | CAS number: 25360-10-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2011-10-28 to 2011-11-08
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study is considered reliable without restriction. The study was followed GLP and adhered to the recommendations of OECD Guideline 404.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 1,1-dimethylheptanethiol
- EC Number:
- 246-896-9
- EC Name:
- 1,1-dimethylheptanethiol
- Cas Number:
- 25360-10-5
- Molecular formula:
- C9H20S
- IUPAC Name:
- 3,5-dimethylheptane-3-thiol
- Test material form:
- other: Clear Liquid
- Details on test material:
- - Name of test material (as cited in study report): 1,1 dimethylheptanethiol
- Substance type: Aliphatic thiol
- Physical state: Liquid
- Analytical purity: 97.87%
- Lot/batch No.: 11BPTNM02
- Storage condition of test material: At room temperature and in the dark
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Huntingdon Life Sciences Limited
- Age at study initiation: Approximately 39 weeks
- Weight at study initiation: 4.09 to 4.40 kg
- Housing: individually in plastic cages with perforated floors
- Diet (e.g. ad libitum): 125 g of a standard laboratory rabbit diet per day
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 20 weeks
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 16 to 20°C
- Humidity (%): 40 to 70%
- Air changes (per hr): Not reported
- Photoperiod (hrs dark / hrs light): 12 hrs dark/12 hrs light
IN-LIFE DATES: Not available
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of treatment / exposure:
- 4 hours
- Observation period:
- Four days
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: dorso-lumbar region
- % coverage: appropriate area
- Type of wrap if used: 2-ply 25 mm x 25 mm porous gauze pad secured with ‘blenderm’ surgical tape covered with cotton wool and "Tubigrip" elasticated bandage dressing
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Yes, lukewarm water (30-40°C)
- Time after start of exposure: 4 hours
SCORING SYSTEM: See 'Any other information on materials and methods incl. tables'
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24, 48, and 72 hours
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24, 48, and 72 hours
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- Very slight erythema and oedema were apparent at the test site of one animal one hour after bandage removal; the erythema persisted to the 24 hour examination. All test sites were overtly normal 48 hours after bandage removal.
- Other effects:
- There was no sign of toxicity or ill health in any rabbit during the observation period.
Any other information on results incl. tables
Table 2. Erythema and Oedema Scores
Test Animal |
24-, 48-, and 72-hour mean scores |
|
|
Erythema |
Oedema |
1 |
0.0 |
0.0 |
2 |
0.0 |
0.0 |
3 |
0.0 |
0.0 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the lack of irritation (erythema and oedema) observed in rabbits, 1,1-dimethylheptanethiol is not considered to be irritating to the skin.
- Executive summary:
In a dermal irritation study, three New Zealand White rabbits were dermally administered 0.5 mL of 1,1-dimethylheptanethiol. The test material was applied undiluted to the clipped dorso-lumbar region of each animal and covered with semi-occlusive wrap for a period of 4 hours. An additional site was similarly treated with the exception of test substance and acted as a control. All animals were subsequently observed for a period of four days.
Very-slight erythema and oedema were apparent at the test site of one animal one hour after bandage removal. The erythema persisted to the 24 hour examination but all test sites were normal 48 hours after bandage removal. The mean 24-, 48-, and 72-hour erythema and oedema scores were 0. No other signs of test-material related clinical toxicity were observed during the study.
Based on the lack of effects observed in this study, 1,1-dimethylheptanethiol is not considered to be irritating to the rabbit skin.
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