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EC number: 236-537-4 | CAS number: 13423-15-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11/15/85 - 12/4/85
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guidline study with accepatable restrictions, e.g. Study did not attempt concentrations over 6700 ppm.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 433 draft (Acute Inhalation Toxicity: Fixed Concentration Procedure) (not officially approved)
- GLP compliance:
- yes
- Test type:
- fixed concentration procedure
- Limit test:
- no
Test material
- Reference substance name:
- Tetrahydro-3-methylfuran
- EC Number:
- 236-537-4
- EC Name:
- Tetrahydro-3-methylfuran
- Cas Number:
- 13423-15-9
- Molecular formula:
- C5H10O
- IUPAC Name:
- tetrahydro-3-methylfuran
- Details on test material:
- Purity = 99.4%
250 ppm BHT added as stabilizer
tetrahydrofuran listed as contaminant
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Groups of 6 rats , 8 weeks old and weighing between 225 and 270 grams were restrained in perforated, stainless steel cylinders with conical nose pieces. Each group was exposed nose-only for a single. 4- hour period to a vapor atmosphere of 30 mehtyltetrahydrofuran in air. Rats were weighed prior to exposure, and were observed for clinical signs of toxicity during exposure.
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- nose only
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: animals restrained in perforated, stainless stell cylinder with conical nose pieces
- Method of holding animals in test chamber:animals restrained in perforated, stainless stell cylinder
- Treatment of exhaust air: drawn through a cold trap and MSA cartridge filter prior to being discharged int the hood.
- Temperature, humidity, pressure in air chamber: temperature ranged between 29-31oC, relative humidity ranged from 78-82%
TEST ATMOSPHERE
atmospheric concentration determined at 30-min intervals during exposure by gas chromatograpgh equiped with a flame ionization detector.
- Samples taken from breathing zone: yes - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- GC chromatograph
- Duration of exposure:
- 4 h
- Concentrations:
- 900, 1600, 3200 and 6700 ppm
- No. of animals per sex per dose:
- 6
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily
- Necropsy of survivors performed: no
:
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- other: ALC
- Effect level:
- > 6 700 ppm
- Based on:
- test mat.
- Remarks on result:
- other: Approximate Lethal Concentration (ALC) is the lowest atmospheric concentration that caused death in 1 or more rats.
- Mortality:
- Under the conditions of this test, no rats died following exposure to 3-methyltetrahydrofuran at concntrations up to 6700 ppm.
- Clinical signs:
- other: During or immediately following exposure, rats in all groups had red nasal or ocular discharges, effects common in rats under restraint. Rats exposed to 3200 ppm and rats exposed to 6700 ppm had a diminished startle response during exposure. In addition,
- Body weight:
- During the postexposure period, rats exposed to 900, 1600 or 3200 ppm had minimal weight loss (average less than 3%) 1 day after exposure, followed by normal weight gain. Rats exposed to 6700 ppm lost a average of 8% of initial body weight.
Any other information on results incl. tables
Acute Inhalation Concentration (ppm) |
Mortality |
||
Mean |
S.D |
Range |
(# Deaths / # Exposed) |
900 |
34 |
840 - 950 |
0/6 |
1600 |
120 |
1500 - 1900 |
0/6 |
3200 |
160 |
2900 - 3400 |
0/6 |
6700 |
470 |
6000 - 7400 |
0/6 |
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information
- Conclusions:
- Under the conditions of this study, the lowest atmospheric concentration that caused death in 1 or more rats (ALC) for 3-methyltetrahydrofuran was greater than 6700 ppm and is considered to have very low toxicity on the acute inhalation basis (ALC > 5000 ppm)
- Executive summary:
Groups of 6 male Crl CD (SD) BR rats were exposed to vapor atmosphere of 3 -methyltetrahydrofuran for a single, 4 hour period. Under the conditions of this test, the lowest atmospheric concentration tested that caused the death of 1 or more rats, either on the day of exposure or within 14 days post exposure for 3-methyltetrahydrofuran was greater than 6400 ppm. This material is considered to have a very low toxicity on an acute inhalation basis.
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