Registration Dossier
Registration Dossier
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EC number: 210-676-0 | CAS number: 621-29-4
Specific investigations: other studies
Administrative data
- Endpoint:
- biochemical or cellular interactions
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The publication is in accordance with generally accepted scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Inhibition of growth of Ehrlich ascites tumors in ICR/Ha Swiss mice by isocyanate
- Author:
- Moos GE, Maguire JA, Kitchlew TZ, Swyers WA, Volk PZ, Croft JR, Quigley MJ, Fries JR, Oser NA, Anderson LJ
- Year:
- 1 971
- Bibliographic source:
- Cancer Res. 31, 937-941.
Materials and methods
- Type of method:
- in vitro
Test material
- Reference substance name:
- m-tolyl isocyanate
- EC Number:
- 210-676-0
- EC Name:
- m-tolyl isocyanate
- Cas Number:
- 621-29-4
- Molecular formula:
- C8H7NO
- IUPAC Name:
- 1-isocyanato-3-methylbenzene
- Details on test material:
- m-tolylisocyanate was received from Eastman Organic Chemicals Department (Rochester, N.Y.)
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- peanut oil
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 7 injections
- Frequency of treatment:
- daily
- Post exposure period:
- 1 day (animals were sacrificed on day 8)
Doses / concentrations
- Remarks:
- Doses / Concentrations:
20 mg/kg bw/d
Basis:
nominal conc.
- No. of animals per sex per dose:
- test: 10 animals
control: 20 animals - Control animals:
- yes, concurrent vehicle
Results and discussion
Any other information on results incl. tables
i.p. injections of 20 mg/kg/day over 7 days inhibition of growth of Ehrlich ascites tumors in ICR/Ha Swiss mice and
lengthening of the mean survival times of mice with Ehrlich ascites tumors
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
