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Reaction mass of 2-{[3-(trimethoxysilyl)propyl]amino}ethanaminium chloride and 2-{benzyl[3-(trimethoxysilyl)propyl]amino}ethanaminium chloride and N-[2-(benzylamino)ethyl]-3-(trimethoxysilyl)propan-1-aminium chloride and N-[2-(dibenzylamino)ethyl]-3-(trimethoxysilyl)propan-1-aminium chloride and N-benzyl-2-{benzyl[3-(trimethoxysilyl)propyl]amino}ethanaminium chloride and N-benzyl-N-[2-(dibenzylamino)ethyl]-3-(trimethoxysilyl)propan-1-aminium chloride.
EC number: 700-961-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in soil
Administrative data
- Endpoint:
- biodegradation in soil: simulation testing
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: EU Method C.10 ("Abiotic degradation: Hydrolysis as a function of pH")
- GLP compliance:
- yes
- Radiolabelling:
- no
- Analytical monitoring:
- no
- Estimation method (if used):
- Chemical analysis using Gas Chromatographic analytical method to determine the concentration of organifucntional silane A-1128 in the solution. The test substance is dissolved in methanol. The concentration of the test substance is determined before and after addition of water.
- Details on test conditions:
- TEST MEDIUM
- Volume used/treatment: no
- Preparation of test medium: A standard solution of the resulting residue was perpared in methanol (LiChrosolv, Merck, Darmstadt, FRG) at the concentration 1.9 g/L. This stock solution was diluted 10 times with methanol. Also dilutions were perpared with addition of 0.2, 1.0, 5.0 and 10.0% Milli-Q water (Millipore Corp.)
- If no traps were used, is the test system closed: After evaporation step the test substance-containing container was flushed with nitrogen and closed.
OTHER TEST CONDITIONS
- Temperature: The test was performed at ambient temperature and remained below 30 °C during the evaporation procedure - Duration:
- 16.8 min
- Initial conc. measured:
- 190 mg/L
- Number of replicates:
- 5
- Preliminary study:
- For results see field `any other information on results incl. tables´
- Transformation products:
- not measured
- Hydrolysis rate constant:
- < 16 min-1
- Conclusions:
- Hence it was concluded that organofunctional silane A-1128 is extremely hydrolytically unstable.
Table 1: Results of the preliminary test. |
||||
Concentration test substance (mg/l)0 after addition of % water. |
||||
0% |
0.2% |
1.0% |
5.0% |
10.0% |
1901(100%)2 |
188 (99%) |
131 (69%) |
53 (28%) |
0 (0%) |
0Mean value of duplicate analysis, quantification was performed with the peak with tr16.8 min. 1Weighed amount. 2Percentage between brackets is relative concentration. |
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28 Apr - 26 May 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.5 (Degradation: Biochemical Oxygen Demand)
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- other: activated sludge, municipal
- Details on inoculum:
- - Source of inoculum/activated sludge: Activated sludge was freshly obtained from municipal sewage treatment plant: Waterschap de Aa, Schijndel, The Netherlands
- Pretreatment: The activated sludge was aerated for 4 hours. It was then left to settle for at least 1/2 hour. The supernatant was decanted to provide a sufficiently large volume for a 1% inoculum for each test flask. - Duration of test (contact time):
- 28 d
- Initial conc.:
- 10 mg/L
- Based on:
- test mat.
- Initial conc.:
- 20 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- TEST CONDITIONS
- Composition of medium: The following amounts of stock solutions were added per litre of Milli-Q water for the formulation of the nutrient medium: 2 mL of solution A, 1 mL of solution B, 1 mL, 1 mL of solution C, 4 mL of solution D, 1 mL of solution E. All nutrients were added to Milli-Q water in such a way that no precipitation occurred. After pretreatment weighed amount of test substance, 33.9 and 65.1 mg, were quantitatively added to 3 L test medium.
- Stock solution:
A) 8.50 g KH2PO4, 21.75 g K2HPO4, 67.20 g Na2HPO4 x 12H2O, 0.50 g NH4Cl, dissolved in 1 L Milli-Q water, pH 7.4±0.2
B) 22.50 g MgSO4 x 7H2O, dissolved in 1 L Milli-Q water
C) 36.40 g CaCl2 x 2H2O, dissolved in 1 L Milli-Q water
D) 0.15 g FeCl3, dissolved in 1 L Milli-Q water
E) 40.0 g (NH4)2SO4, dissolved in 1 L Milli-Q water
- Additional substrate: 4 g Barium hydroxide per L Milli-Q water was filtered through filter paper and stored in a sealed vessel to prevent absorption of CO2 from the air. After the aeration period, three CO2-absorber bottles were filled with 80 mL 0.025 N Ba(OH)2.
- Test temperature: 20 ± 2 °C
- pH: blank 6.7, positive control 6.46, organofunctional silane A-1128 (10 mg/L) 6.44, organofunctional silane A-1128 (20 mg/L) 5.57
- Aeration: The mixture was aerated with CO2-free air for 24 hours (pre-incubation medium); on the 26th day, the bottles were aerated overnight
TEST SYSTEM
- Culturing apparatus: CO2-absorber
- Number of culture flasks/concentration: 2 flasks and 2 concentrations
SAMPLING
- Sampling frequency: every day for the first 10 days, and thereafter every fifth day until the 28th day
- Sampling method: Titration
CONTROL AND BLANK SYSTEM
- Inoculum blank: contained inoculum but neither test nor control substance
- positive control: 20 mg/L sodium acetate (Merck art. 6268, batch 049 TA933768) - Parameter:
- % degradation (CO2 evolution)
- Value:
- 28.8
- Sampling time:
- 28 d
- Remarks on result:
- other: 10 mg/L of test substance
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 16.7
- Sampling time:
- 28 d
- Remarks on result:
- other: 20 mg/L of test substance
- Details on results:
- The control substance was biodegraded by more than 60% within 12 days and 76% degradation was reached at the end of the test period. The total CO2 release in the blank reached a total value of 20 mg CO2.
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- Although substantial biodegradation was recorded after 28 days of incubation, organofunctional silane A-1128 was not readily biodegradable under conditions in the modified Sturm test presently performed.
Table 1: CO2 -evolution and percentage of biodegradation of the positive control substance. |
|||||||
Day |
Titrant Blank (mL) |
Titrant CO2trap (mL) |
Produced CO2 in mL HCL |
Normality HCL |
Produced CO2 CO2mg |
Cumulative CO2mg |
Degrad. % |
2 |
38.78 |
36.65 |
2.13 |
0.048 |
2.25 |
2.25 |
3.4 |
5 |
37.01 |
21.92 |
15.09 |
0.048 |
15.94 |
15.94 |
24.1 |
7 |
36.50 |
28.01 |
8.49 |
0.048 |
8.97 |
24.91 |
37.6 |
10 |
38.87 |
34.05 |
4.82 |
0.048 |
5.09 |
30.00 |
45.3 |
12 |
38.28 |
26.03a |
12.25 |
0.048 |
12.94 |
42.94 |
64.9 |
16 |
36.22 |
32.08 |
4.14 |
0.048 |
4.37 |
47.31 |
71.5 |
21 |
35.94 |
33.79 |
2.15 |
0.048 |
2.27 |
49.58 |
74.9 |
26 |
38.04 |
37.55 |
0.49 |
0.048 |
0.52 |
50.10 |
75.7 |
28 |
34.79 |
36.35 |
0.00 |
0.048 |
0.00 |
50.10 |
75.7 |
28 |
36.12 |
37.87 |
0.00 |
0.048 |
0.00 |
50.10 |
75.7 |
28 |
38.39 |
39.28 |
0.00 |
0.048 |
0.00 |
50.10 |
75.7 |
Theoretical CO2production sodium acetate: 66.2 mg CO2/3L aturbid solution |
Table 2: CO2 -evolution and percentage of biodegradation of the test substance (low concentration). |
|||||||
Day |
Titrant Blank (mL) |
Titrant CO2trap (mL) |
Produced CO2 in mL HCL |
Normality HCL |
Produced CO2 CO2mg |
Cumulative CO2mg |
Degrad. % |
2 |
38.78 |
38.08 |
0.70 |
0.048 |
0.74 |
0.74 |
1.4 |
5 |
37.01 |
35.90 |
1.11 |
0.048 |
1.17 |
1.17 |
2.2 |
7 |
36.50 |
34.95 |
1.54 |
0.048 |
1.63 |
2.80 |
5.3 |
10 |
38.87 |
34.77 |
4.10 |
0.048 |
4.33 |
7.13 |
13.4 |
12 |
38.28 |
37.06 |
1.22 |
0.048 |
1.29 |
8.42 |
15.9 |
16 |
36.22 |
35.54 |
0.68 |
0.048 |
0.72 |
9.14 |
17.2 |
21 |
35.94 |
34.56 |
1.38 |
0.048 |
1.46 |
10.60 |
20.0 |
26 |
38.04 |
35.19 |
2.85 |
0.048 |
3.01 |
13.61 |
25.6 |
28 |
34.79 |
34.22 |
0.57 |
0.048 |
0.60 |
14.21 |
26.8 |
28 |
36.12 |
35.12 |
1.00 |
0.048 |
1.06 |
15.27 |
28.8 |
28 |
38.39 |
38.97 |
0.00 |
0.048 |
0.00 |
15.27 |
28.8 |
Theoretical CO2production (low concentration): 53.1 mg CO2/3L |
Table 3: CO2 -evolution and percentage of biodegradation of the test substance (high concentration). |
|||||||
Day |
Titrant Blank (mL) |
Titrant CO2trap (mL) |
Produced CO2 in mL HCL |
Normality HCL |
Produced CO2 CO2mg |
Cumulative CO2mg |
Degrad. % |
2 |
38.78 |
38.19 |
0.59 |
0.048 |
0.62 |
0.62 |
0.6 |
5 |
37.01 |
33.95 |
3.06 |
0.048 |
3.23 |
3.23 |
3.2 |
7 |
36.50 |
34.27 |
2.23 |
0.048 |
2.35 |
5.58 |
5.5 |
10 |
38.87 |
32.87 |
6.00 |
0.048 |
6.34 |
11.92 |
11.7 |
12 |
38.28 |
36.71 |
1.57 |
0.048 |
1.66 |
13.58 |
13.3 |
16 |
36.22 |
33.59 |
2.63 |
0.048 |
2.78 |
16.36 |
16.1 |
21 |
35.94 |
37.02 |
0.00 |
0.048 |
0.00 |
16.36 |
16.1 |
26 |
38.04 |
37.45 |
0.59 |
0.048 |
0.62 |
16.98 |
16.7 |
28 |
34.79 |
37.01 |
0.00 |
0.048 |
0.00 |
16.98 |
16.7 |
28 |
36.12 |
37.44 |
0.00 |
0.048 |
0.00 |
16.98 |
16.7 |
28 |
38.39 |
39.08 |
0.00 |
0.048 |
0.00 |
16.98 |
16.7 |
Theoretical CO2production (low concentration): 101.9 mg CO2/3L |
Table 4: CO2-evolution in the blank. |
||||||
Day |
Titrant Blank (mL) |
Titrant CO2trap (mL) |
Produced CO2 in mL HCL |
Normality HCL |
Produced CO2 CO2mg |
Cumulative CO2mg |
2 |
38.78 |
38.19 |
0.59 |
0.048 |
0.62 |
0.62 |
5 |
37.01 |
33.95 |
3.06 |
0.048 |
3.23 |
3.23 |
7 |
36.50 |
34.27 |
2.23 |
0.048 |
2.35 |
5.58 |
10 |
38.87 |
32.87 |
6.00 |
0.048 |
6.34 |
11.92 |
12 |
38.28 |
36.71 |
1.57 |
0.048 |
1.66 |
13.58 |
16 |
36.22 |
33.59 |
2.63 |
0.048 |
2.78 |
16.36 |
21 |
35.94 |
37.02 |
0.00 |
0.048 |
0.00 |
16.36 |
26 |
38.04 |
37.45 |
0.59 |
0.048 |
0.62 |
16.98 |
28 |
34.79 |
37.01 |
0.00 |
0.048 |
0.00 |
16.98 |
28 |
36.12 |
37.44 |
0.00 |
0.048 |
0.00 |
16.98 |
28 |
38.39 |
39.08 |
0.00 |
0.048 |
0.00 |
16.98 |
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint:
- bioaccumulation in aquatic species: fish
- Data waiving:
- other justification
- Justification for data waiving:
- other:
- Reason / purpose for cross-reference:
- data waiving: supporting information
- Reason / purpose for cross-reference:
- data waiving: supporting information
- Reason / purpose for cross-reference:
- data waiving: supporting information
Data source
Materials and methods
Test material
- Reference substance name:
- Reaction mass of 2-{[3-(trimethoxysilyl)propyl]amino}ethanaminium chloride and 2-{benzyl[3-(trimethoxysilyl)propyl]amino}ethanaminium chloride and N-[2-(benzylamino)ethyl]-3-(trimethoxysilyl)propan-1-aminium chloride and N-[2-(dibenzylamino)ethyl]-3-(trimethoxysilyl)propan-1-aminium chloride and N-benzyl-2-{benzyl[3-(trimethoxysilyl)propyl]amino}ethanaminium chloride and N-benzyl-N-[2-(dibenzylamino)ethyl]-3-(trimethoxysilyl)propan-1-aminium chloride.
- Molecular formula:
- Not applicable
- IUPAC Name:
- Reaction mass of 2-{[3-(trimethoxysilyl)propyl]amino}ethanaminium chloride and 2-{benzyl[3-(trimethoxysilyl)propyl]amino}ethanaminium chloride and N-[2-(benzylamino)ethyl]-3-(trimethoxysilyl)propan-1-aminium chloride and N-[2-(dibenzylamino)ethyl]-3-(trimethoxysilyl)propan-1-aminium chloride and N-benzyl-2-{benzyl[3-(trimethoxysilyl)propyl]amino}ethanaminium chloride and N-benzyl-N-[2-(dibenzylamino)ethyl]-3-(trimethoxysilyl)propan-1-aminium chloride.
Constituent 1
Results and discussion
- Transformation products:
- yes
- Remarks:
- Degradation is principally expected via abiotic transformation (aqueous). The transformation products expected are those identified in IUCLID section 1.10 "transformation of the registered substance", the environmental hazard assessment is based on those.
Identity of transformation productsopen allclose all
- No.:
- #1
Reference
- Reference substance name:
- Unnamed
- IUPAC name:
- Reaction mass of 2-{[3-(trihydroxysilyl)propyl]amino}ethanaminium chloride and 2-{benzyl[3-(trihydroxysilyl)propyl]amino}ethanaminium chloride and N-[2-(benzylamino)ethyl]-3-(trihydroxysilyl)propan-1-aminium chloride and N-[2-(dibenzylamino)ethyl]-3-(trihydroxysilyl)propan-1-aminium chloride and N-benzyl-2-{benzyl[3-(trihydroxysilyl)propyl]amino}ethanaminium chloride and N-benzyl-N-[2-(dibenzylamino)ethyl]-3-(trihydroxysilyl)propan-1-aminium chloride.
- Identifier:
- common name
- Identity:
- Reaction mass of 2-{[3-(trihydroxysilyl)propyl]amino}ethanaminium chloride and 2-{benzyl[3-(trihydroxysilyl)propyl]amino}ethanaminium chloride and N-[2-(benzylamino)ethyl]-3-(trihydroxysilyl)propan-1-aminium chloride and N-[2-(dibenzylamino)ethyl]-3-(trihydroxysilyl)propan-1-aminium chloride and N-benzyl-2-{benzyl[3-(trihydroxysilyl)propyl]amino}ethanaminium chloride and N-benzyl-N-[2-(dibenzylamino)ethyl]-3-(trihydroxysilyl)propan-1-aminium chloride.
- Molecular weight:
- >= 216.8 - <= 487.1
- No.:
- #2
Reference
- Reference substance name:
- Unnamed
- IUPAC name:
- Methyl alcohol
- Inventory number:
- InventoryMultipleMappingImpl [inventoryEntryValue=EC 200-659-6]
- CAS number:
- 67-56-1
- Identity:
- MeOH
- Molecular formula:
- CH4O
- Molecular weight:
- ca. 32.04
- SMILES notation:
- OC
- InChl:
- InChI=1/CH4O/c1-2/h2H,1H3
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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