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EC number: 282-762-6 | CAS number: 84418-50-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1980-09-24 to 1980-10-08
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Comparable to guideline study with acceptable restrictions
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Version / remarks:
- 1981-05-12
- Deviations:
- yes
- Remarks:
- information on strain of rats, equilibration period, and on time period of observations were missing; rats were not weighed weekly
- Principles of method if other than guideline:
- It has to be mentioned that no OECD guideline was available at the time of conduct.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Naphthenic acids, zinc salts
- EC Number:
- 234-409-2
- EC Name:
- Naphthenic acids, zinc salts
- Cas Number:
- 12001-85-3
- IUPAC Name:
- zinc bis[3-(3-ethylcyclopentyl)propanoate]
- Test material form:
- other: solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS - albino rats
- Housing: the animals were housed and maintained in compliance with the Animal Welfare Act (Pub. L-94-279) 9 CFR Part 3.
- Weight at study initiation: average initial body weight: 210 g (males) and 205 g (females)
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: mineral spirits and clean air
- Details on inhalation exposure:
- PREPARATION OF TEST MATERIAL
The material was used as a 50% w/v suspension in mineral spirits
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: the animals were exposed to the test material inside a 260 liter plexiglass exposure chamber.
- System of generating particulates/aerosols: the material was administered as an aerosol which was generated by a six jet Collision nebulizer (BGI Incorporated, Waltham, Mass.). The air was passed through a desicant prior to being passed through the test material. The rate of flow through the chamber was 20 liters per minute (except during particle size measurement) at a temperature of 72°F (22.2°C).
- Method of particle size determination: particle size of the aerosol was determined using an Andersen Sampler cascade impactor. The Andersen Sampler was run for 5 minutes midway through the exposure. During sampling, air from the breathing zone of the animals was drawn through the cascade impactor at the rate of 1 cubic foot per minute (28.3 liters per minute).
The amount of aerosol impacting on each plate of the Andersen Sampler was determined by differential weighing. From these values the mass median diameter of the aerosol was calculated to be 0.54u and the concentration was calculated to be 0.42 mg/liter.
TEST ATMOSPHERE
The average concentration of the aerosol over the four hour exposure period was calculated to be 11.6 mg/liter by differential weighing of the flask from which the aerosol was generated. - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- please refer to "details on inhalation exposure" above
- Duration of exposure:
- 4 h
- Concentrations:
- Actual concentration: 0.42 mg/liter (maximum concentration which could be attained)
Nominal concentration: 11.6 mg/liter - No. of animals per sex per dose:
- 5 males / 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Examinations performed: Signs of toxicity and mortalities (daily) were noted. The average initial body weight and the average final body weight were determined. - Statistics:
- not stated
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 420 mg/m³ air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: the maximum concentration which could be attained
- Mortality:
- No mortality occurred during the study.
- Clinical signs:
- other: No untoward symptoms were observed during the four hour exposure period. Within 18 - 24 hours the animals appeared depressed and ruffled. They were essentially normal after 48 hours.
- Body weight:
- The average body weight of the rats increased during the study.
- Gross pathology:
- Gross pathological examination revealed nothing remarkable.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Conclusions:
- LC50 (male and female rats, 4h) > 0.42 mg/liter (analytical); test was conducted at the maximum attainable concentration.
According to the EC-Regulation 1272/2008 and its subsequent Amendments, the test item is not classified as acute toxic via the inhalation route.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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