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Diss Factsheets
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EC number: 205-466-0 | CAS number: 141-18-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
A basic toxicokinetics assessment was prepared based on physicochemical and toxicological properties according to REACH R.7C Guidance. Absorption was considered to be most likely by oral route. Distribution is considered to be possible, but limited due to low water solubility. Intracellular concentration is expected to be higher than extracellular concentration, based on its rather lipophilic character. Although urinary excretion is not expected, most probably biotransformation to more polar and water soluble substances will lead to elimination via the kidney. As the substance is rather lipid soluble, other excretion routes such as via the bile are possible.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 80
- Absorption rate - dermal (%):
- 20
- Absorption rate - inhalation (%):
- 100
Additional information
Absorption of Bis(2-butoxyethyl) adipate was assessed based on physicochemical/toxicological data:
- Oral absorption is assumed to be possible, but moderate. Based on the low water solubility (101 mg/L), a high systemic exposure seems unlikely as in general a compound needs to be dissolved before it can be taken up from the gastro-intestinal tract. However, its rather highly lipophilic character (log P 3.78) may promote uptake by micellular solubilisation and the molecular weight (346.46) also allows absorption. The oral route is considered to be the default route for toxicity testing. An oral absorption of 80% is proposed from a conservative viewpoint for risk assessment purposes.
- Bis(2-butoxyethyl)adipate aerosol particles may theoretically be absorbed by the lungs, however based on the very low vapour pressure (0.00559 Pa), the probability that it enters the airways is low, certainly at the lower respiratory tract (alveoli).If reaching the alveoli, an inhalation absorption of 100% is considered from a conservative viewpoint for risk assessment purposes (or for DNEL calculation).
- Dermal absorption is considered to be very low, which is confirmed by the calculation in Dermwin, demonstrating a very low dermal permeability coefficient (0.006 cm/hour) and very low dermally absorbed daily dose (0.015 mg/kg bw/day).A dermal absorption of 20% is proposed for risk assessment purposes (or for DNEL calculation).
Once absorbed, further assessment of distribution, metabolism and accumulation and excretion of Bis(2-butoxyethyl) adipate were assessed as follows:
- Distribution is considered to be possible, however limited due to low water solubility. However, as distribution mostly takes place by protein binding, it is possible, as demonstrated by toxicity in the repeated dose toxicity study. Intracellular concentration is expected to be higher than extracellular concentration, based on its rather lipophilic character.
- Based on the lipid solubility it may concentrate in adipose tissue depending on the conditions of exposure, however accumulation is not expected. Once exposure stops, the concentration in the body will most probably decline at a rate determined by the half-life of the substance.
- Although urinary excretion is not expected, most probably biotransformation to more polar and water soluble substances will lead to elimination via the kidney. As the substance is rather lipid soluble, other excretion routes such as via the bile and milk (if applicable) are possible. Accumulation is not expected.
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