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EC number: 251-257-2 | CAS number: 32846-21-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14 April, 2014 to 02 September, 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- The test item solutions were prepared by adding 1 mL of a 1000 mg/L stock solution into an 100 mL volumetric flask and accurately filled up with the buffer solutions. Under argon atmosphere 2.0 mL of the test item solutions were given into several amber glass vials. The vials were closed with Teflon sealed screw caps. At the sampling time the samples were diluted with 2.0 mL acetonitrile. The concentration did not exceed 0.01 M or the half saturation concentration. The determined effective concentrations prior to storage at 50 °C were 9.49 mg/L at pH 4, 9.66 mg/L at pH 7 and 9.88 mg/L at pH 9.
- Buffers:
- The test was carried out at three different pH values: 4.0, 7.0 and 9.0.
For this purpose, buffer solutions were prepared using reagent grade chemicals and deionized water. Applicable buffer systems are described in the Appendix of OECD guideline 111 or BBA Merkblatt Nr.55, Teil I.
The citrate buffer pH 4, the phosphate buffer pH 7 and the borate buffer
pH 9 were prepared in a concentration of 0.05 M on the basis of the undissociated acids.
The pH value of the buffer solutions used during the test were determined with a calibrated pH meter at the selected temperature with a precision of
0.1 pH units. - Details on test conditions:
- The test was carried out using a thermostatically controlled water bath at +/- 0.5 °C of the chosen temperature. The temperature was kept and
measured to within +/- 0.1 °C. Photolytic interference was avoided. All suitable precautions were taken to exclude dissolved oxygen (bubbling the
buffer with argon for five minutes before preparing the test solution). - Duration:
- 120 h
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 9.49 mg/L
- Duration:
- 120 h
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 9.66 mg/L
- Duration:
- 120 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 9.88 mg/L
- Number of replicates:
- 4 at each pH-value
- Preliminary study:
- No significant changes of the content in the samples were observed. At pH 4, 7 and 9, less than 10 % of the test item were hydrolysed within 120 hours at 50 degC.
- Transformation products:
- not measured
- % Recovery:
- 101.1
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 120 h
- % Recovery:
- 99.4
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 120 h
- % Recovery:
- 96.7
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 120 h
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- (pseudo-)first order (= half-life)
- Validity criteria fulfilled:
- yes
- Conclusions:
- The half-life time for FAT 20003/K at pH 4, 7 and 9 at 25 °C were estimated to be longer than one year.
- Executive summary:
The abiotic degradation of FAT 20003/K TE as a function of pH in aqueous solution was determined according to OECD guideline 111 and EC method C.7 (440/2008). A preliminary test was performed at 50 +/- 0.5 °C at three pH values: 4.0, 7.0 and 9.0. A sufficient number of measurements were made, in order to be able to estimate whether for each pH value and at 50 °C, the half-life time (t1/2) is less than 10 % of hydrolysis after 120 hours.
No significant changes of the content in the samples were observed. At pH 4, 7 and 9 less than 10 % of the test item were hydrolysed within 120 hours at 50 °C. Hence based on the findings of the preliminary study, it was shown that the hydrolysis of FAT 20003/K TE is negligible within the pH range relevant for natural environments (pH 4 to pH 9). The half-life times at pH 4, 7 and 9 are expected to be above one year at 25 °C in each case. Because the test item is stable to hydrolysis no further hydrolysis tests are necessary.
Reference
Table 1: Time course of FAT 20003/K TE concentration at pH 4 at 50 °C
Time |
Determined Content of FAT 20003/K TE in Sample |
Actual concentration |
|
[h] |
[mg/L] |
in % of initial conc. |
|
0 |
9.49 |
100.0 |
|
120 |
9.59 |
101.1 |
Table 2: Time course of FAT 20003/K TE concentration at pH 7 at 50 °C
Time |
Determined Content of FAT 20003/K TE in Sample |
Actual concentration |
|
[h] |
[mg/L] |
in % of initial conc. |
|
0 |
9.66 |
100.0 |
|
120 |
9.60 |
99.4 |
Table 3: Time course of FAT 20003/K TE concentration at pH 9 at 50 °C
Time |
Determined Content of FAT 20003/K TE in Sample |
Actual concentration |
|
[h] |
[mg/L] |
in % of initial conc. |
|
0 |
9.88 |
100.0 |
|
120 |
9.55 |
96.7 |
Description of key information
The abiotic degradation of FAT 20003/K TE as a function of pH in aqueous solution was determined according to OECD guideline 111 and EC method C.7 (440/2008).A preliminary test was performed at 50 +/- 0.5 °C at three pH values: 4.0, 7.0 and 9.0. A sufficient number of measurements were made, in order to be able to estimate whether for each pH value and at 50 °C, the half-life time (t1/2) is less than 10 % of hydrolysis after 120 hours.
No significant changes of the content in the samples were observed. At pH 4, 7 and 9 less than 10 % of the test item were hydrolysed within 120 hours at 50 °C. Hence based on the findings of the preliminary study, it was shown that the hydrolysis of FAT 20003/K TE is negligible within the pH range relevant for natural environments (pH 4 to pH 9). The half-life times at pH 4, 7 and 9 are expected to be above one year at 25 °C in each case. Because the test item is stable to hydrolysis no further hydrolysis tests are necessary.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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