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EC number: 203-635-3 | CAS number: 108-98-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2001
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Benzenethiol
- EC Number:
- 203-635-3
- EC Name:
- Benzenethiol
- Cas Number:
- 108-98-5
- Molecular formula:
- C6H6S
- IUPAC Name:
- benzenethiol
- Details on test material:
- - Name of test material : benzenthiol
- Molecular formula : C6H6S
- Molecular weight : 110.18
- Substance type: liquid (a clear, colorless)
- Analytical purity: >=98.0%
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
- Melting point: -14.8℃
- Boiling point: 168℃
- Vapour pressure:0.13kPa (18℃)
- Water solubility (under test conditions): 836mg/L
- log Pow:2.52
- pKa: 6.62
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Test solution (1.0mL~1.5mL) was obtained each test aquarium and analyzed by HPLC.
Graph of Standard curve which was obtained by standard concentration (20,60,100mg/L) led standard factor,and this factor used to obtained concentration of test solution.
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- - Method:
(1)After adding test substances(30.3 mg/L) to dilution water,each concentration of test solutions prepared .
(2)The dilution water only had positive control.
(3)Each test vessels was checked in appearance.
Test organisms
- Test organisms (species):
- Oryzias latipes
- Details on test organisms:
- TEST ORGANISM
- Common name: Oryzias latipes
- Length at study initiation : 2.27 cm (2.10~2.43 cm), n=10
- Weight at study initiation : 0.1842g (0.1474 ~0.2514 g), n=10
- Lot : 000402
- Feeding during test : no
- Food type: TetraMin
- Method of breeding: 10 animals/one concentration
- Light intensity : interior light ,16-hour light/8-hour dark cycle
- Amout of test solution: 3L test solution
ACCLIMATION
- Acclimation period: more than 12 days
- Acclimation conditions : same as test
- Type and amount of food: TetraMin (freeding until 24 hours before the test was started)
- Health during acclimation :0.0% mortality 7days before exposure
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Post exposure observation period:
- no
Test conditions
- Hardness:
- 41.0mg (as CaCO3 ) (dilution water)
- Test temperature:
- 24± 1℃ Temperature was cheked 24 hour intervals.
- pH:
- pH6.8 (dilution water) pH was cheked 24 hour intervals.
- Dissolved oxygen:
- Dissolved oxygen was cheked 24 hour intervals.
- Salinity:
- not applicable
- Nominal and measured concentrations:
- not applicable
- Details on test conditions:
- TEST CONCENTRATIONS
- Spacing factor for test concentrations:
- Justification for using less concentrations than requested by guideline:
- Range finding study
- Test concentrations:
- Results used to determine the conditions for the definitive study:
TEST SYSTEM
- Test vessel:3L glass beaker
- Material, size, headspace, fill volume: 3L
- Aeration: no
- Type of flow-through (e.g. peristaltic or proportional diluter): semi-static
- Renewal rate of test solution : 24 hours
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Dilution water was dechlorination with tap water in Nagoya city.
- Intervals of water quality measurement: 24 hour interval
OTHER TEST CONDITIONS
- Adjustment of pH:
- Photoperiod:
- Light intensity:
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
Results and discussion
Effect concentrations
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.009 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% (0.003~0.018 mg/L)
- Details on results:
- - Behavioural abnormalities: Abnormal breathing,abnormal immobilisation were observed at 0.018mg/Land,0.056mg/L, but control and less than 0.003mg/L concentrations were obseved nothing.
-Test conditions: measured pH was pH6.8~7.1 during 96 hour, measured dissolved oxgen was 5.6~9.7 mg/L and all test aquarium was no less than 60%. measured temparature was 23.4~23.9 ℃ during 96 hour.
- maximum concentration causing no mortality after 96 hours : 0.003 mg/L, minimum concentration causing 100% mortality after 96 hour : 0.056 mg/L
-test subustance concentration : the begining of test:<0.0008~0.489 mg/L ,24 hour later :<0.0008~0.284 mg/L. The nominal concentration was deviated from ±20%, the results was geometric mean of measured concentration.
- Reported statistics and error estimates:
- Binomial method was employed to caluculation LD50 and confidence limits(p=0.95).
Binomial method was used TOXDAT Multi-Method Program.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.