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Diss Factsheets
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EC number: 941-784-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Identification Code: FAT 21030/D
Batch No.: 16.36
Appearance: black solid
Purity: 67% AS
Solubility (in water): 80 g/L
Received : 05/11/93
Storage: room temperature
Stability: 00/12/98 - Analytical monitoring:
- yes
- Details on sampling:
- Sampling for analysis: Composite samples of ech test concentration were drawn by mixing identical volumes of the test solutions taken from the approximate center of the test vessels. They were taken imediately before exposure and after 48 hours exposure and kept at -18 °C to -22 °C until analysis.
- Vehicle:
- no
- Details on test solutions:
- Stock solution : 100.4 mg test substance were mixed and made up to 1000 ml with water.
Calculated amounts of the stock solution to produce the desired test concentrations were given into the water and were homogeneously distributed.After an equilibration time of 7 hours the daphnia were transferred into the beakers. The test substance was homogeneously distributed in the test vessels at all test concentrations at the begin of exposure.
At the end of exposure a deposit was observed at all test concentrations and small parts of the substance were swimming at the surface of the test water at concentrations 21, 46 and 100 mg/l.
Sampling for analysis : Composite samples of each test concentration were drawn by mixing identical volumes of the test solutions taken from the approximate center of the test vessels. They were taken immediately before exposure and after 48 hours exposure and kept at - 18°C to - 22°C until analysis. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Strain: Straus 1820
- Source: CIBA-GEIGY Ltd., testing facility
- Feeding: None during the test
- Breeding: Cultures of daphnia are maintained inglass vessels containing approx. 2.5 liter of reconstituted water (see below) at 20 ± 1 °C (water is renewed partially thrice weekly). At each renewal the daphnia are fed with a suspension of green algae (Scenedesmus subspicatus) supplemented by a suspension of TETRAMIN-extract in such quantities that the food is consumed after 24h.
- Pretreatment: 24 hours before the begin of the exposure reproductive daphnia are separated from the young by sieving all individuals through a 800 micron sieve. This operation is repeated 6 hours before the exposure and the young (6-24h of age) are retained for the test. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- Total hardness: 240 mg CaCO3 L.
- Test temperature:
- 20 +/- 1°C
- pH:
- 7.8-8.0
- Nominal and measured concentrations:
- Nominal: 4.4, 9.6, 21, 46 and 100 mg test substance/L.
Measured start: 7.0, 11.3, 22.9, 49.8 and 105.9 mg/L
Measured end: 7.0, 9.2, 11.2, 15.7 and 31.5 mg test substance/L. - Details on test conditions:
- - Vessels: Beakers covered with watch glasses, 100 ml solution per beaker.
- Aeration: None
- Lighting: Fluorescent light, 16 hours daily, approx. 1500 lux.
Number of daphnia: 20 per concentration and control. 4 replicates of 5 daphnia each.
Water: Reconstituted water containing
65 mg NaHC03
294 mg CaCl2. 2 H20
123 mg MgS04.7 H20
6 mg KCl
In 1000 ml bidistilled water.The water was aerated with clean air for at least 24 hours before use. - Reference substance (positive control):
- no
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- 11 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 32 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- > 32 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 11 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- Controls: Immobilizations in blank: 0 %
- Reported statistics and error estimates:
- None
- Validity criteria fulfilled:
- yes
- Conclusions:
- The EC50 (48h) of FAT 21030/D was found to be greater than 32 mg/l.
- Executive summary:
The short term toxicity potential of the test substance to the aquatic freshwater invertebrate (i.e. Daphnia magna) was studied under GLP and in accordance with EU Method C.2 (Acute Toxicity for Daphnia). The test was conducted over a period of 48 hours at the temperature of 20 °C.
The test concentrations used in this experiment were:
- Nominal: 4.4 / 9.6 / 21 / 46 and 100 mg test substance/L.
- Actual end: 7.0 / 9.2 / 11 / 16 and 32 mg test substance/L.
- Control blank: Water.
Immobilization was recorded after 24 and 48 hours exposure.
Results: EC50 (48h): >32 mg/L
Reference
Results of the analytical determination:
Results:
Blank (Start) 11.01.94; Content of test article in Daphnia water: <2 mg/L
Blank (End) 13.01.94; Content of test article in Daphnia water: <2 mg/L
4.4 mg/L (Start) 11.01.94; Content of test article in Daphnia water: 7 mg/L
4.4 mg/L (End) 13.01.94; Content of test article in Daphnia water: 7 mg/L
9.6 mg/L (Start) 11.01.94; Content of test article in Daphnia water: 11.3 mg/L
9.6 mg/L (End) 13.01.94; Content of test article in Daphnia water: 9.2 mg/L
21 mg/L (Start) 11.01.94; Content of test article in Daphnia water: 22.9 mg/L
21 mg/L (End) 13.01.94; Content of test article in Daphnia water: 11.2 mg/L
46 mg/L (Start) 11.01.94; Content of test article in Daphnia water: 49.8 mg/L
46 mg/L (End) 13.01.94; Content of test article in Daphnia water: 15.7 mg/L
100 mg/L (Start) 11.01.94; Content of test article in Daphnia water: 105.9 mg/L
100 mg/L (End) 13.01.94; Content of test article in Daphnia water: 31.5 mg/L
Description of key information
The short term toxicity potential of the test substance to the aquatic freshwater invertebrate (i.e. Daphnia magna) was studied under GLP and in accordance with EU Method C.2 (Acute Toxicity for Daphnia). The test was conducted over a period of 48 hours at the temperature of 20 °C.
The test concentrations used in this experiment were:
- Nominal: 4.4 / 9.6 / 21 / 46 and 100 mg test substance/L.
- Actual end: 7.0 / 9.2 / 11 / 16 and 32 mg test substance/L.
- Control blank: Water.
Immobilization was recorded after 24 and 48 hours of exposure.
Results: EC50 (48h): >32 mg/L
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 32 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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