Registration Dossier
Registration Dossier
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nonapotassium 2,4,6-trihydroxy-4-methyl-3,5-dioxa-2,4,6-trisilaheptane-2,6-bis(olate) 2,6,8-trihydroxy-4,6-dimethyl-3,5,7-trioxa-2,4,6,8-tetrasilanonane-2,4,8-tris(olate) 6-hydroxy-2,4,6-trimethyl-1,3,5,2,4,6-trioxatrisilinane-2,4-bis(olate) dihydroxy(methyl)silanolate {[dihydroxy(methyl)silyl]oxy}(hydroxy)methylsilanolate
EC number: 935-877-7 | CAS number: -
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
Additional information
No data on the reproductive toxicity of reaction mass of potassium methylsiliconate are available. Reaction mass of potassium methylsiliconate is a multi-constituent substance containing methylsilanetriolate, dimers and oligomers of methylsilanetriolate, and potassium hydroxide. In contact with water the substance is dissolving. The resulting aqueous solution is only stable at high pH. As the pH is lowered, polymerisation occurs. Under comparable conditions of concentration and pH methylsilanetriolate is equivalent to the parent acid, methylsilanetriol.
The surrogate substance, trimethoxy(methyl)silane (CAS 1185-55-3), hydrolyses in contact with water at pH 7 (half-life approx. 2 hours), producing methanol and methylsilanetriol. Under acidic conditions, such as in the stomach following oral ingestion, hydrolysis is very rapid. Since potassium ions will not contribute to any systemic toxicity effect, and methanol does not contribute any significant repeated dose toxicity to rodents at the dose levels tested, and both substances share the same silanol product it is considered appropriate to read across the available data on trimethoxy(methyl)silane. Dimers and oligomers of methylsilanetriol are expected have lower toxicity than the corresponding monomer, therefore use of data on MTMS represents a worst-case interpretation.
Local irritant or corrosive effects due to the high pH of an aqueous solution of the registered substance are not addressed by the read-across data.
Short description of key information:
No data on the reproductive toxicity of reaction mass of potassium methylsiliconate are available, therefore data on trimethoxy(methyl)silane (MTMS) have been read-across. Exposure to trimethoxy(methyl)silane was not associated with reproductive toxicity. The findings support a NOAEL of at least 1000 mg/kg bw/day.
Effects on developmental toxicity
Description of key information
No data on the developmental toxicity of reaction mass of potassium methylsiliconate are available, therefore data on trimethoxy(methyl)silane have been read-across. The findings support a NOAEL of at least 1000 mg/kg bw/day.
Effect on developmental toxicity: via oral route
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
Additional information
No data on the developmental toxicity of reaction mass of potassium methylsiliconate are available. Reaction mass of potassium methylsiliconate is a multi-constituent substance containing methylsilanetriolate, dimers and oligomers of methylsilanetriolate, and potassium hydroxide. In contact with water the substance is dissolving. The resulting aqueous solution is only stable at high pH. As the pH is lowered, polymerisation occurs. Under comparable conditions of concentration and pH methylsilanetriolate is equivalent to the parent acid, methylsilanetriol.
The surrogate substance, trimethoxy(methyl)silane (CAS 1185-55-3), hydrolyses in contact with water at pH 7 (half-life approx. 2 hours), producing methanol and methylsilanetriol. Under acidic conditions, such as in the stomach following oral ingestion, hydrolysis is very rapid. Since potassium ions will not contribute to any systemic toxicity effect, and methanol does not contribute any significant repeated dose toxicity to rodents at the dose levels tested, and both substances share the same silanol product it is considered appropriate to read across the available data on trimethoxy(methyl)silane. Dimers and oligomers of methylsilanetriol are expected have lower toxicity than the corresponding monomer, therefore use of data on MTMS represents a worst-case interpretation.
Local irritant or corrosive effects due to the high pH of an aqueous solution of the registered substance are not addressed by the read-across data.
Justification for classification or non-classification
The available read-across data do not suggest that reaction mass of potassium methylsiliconate should be classified for reproductive and developmental toxicity.
Additional information
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