Registration Dossier
Registration Dossier
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EC number: 222-940-2 | CAS number: 3674-09-7
Carcinogenicity
Administrative data
Description of key information
Experimental data on carcinogenicity are not available.
KLOB-010 is predicted as suspected carcinogen; the Toolbox profiler carcinogenicity (genotox and nongenotox) alerts by ISS gives an alert for carcinogenicity (Aliphatic halogens (Genotox)).
Predictions on carcinogenicity obtained by Vega and Danish EPA models are not reliable.
In general, the genotoxic potential is dependent on the nature, number, and position of halogen(s) and the molecular size of the compound. Moreover, biotransformation (Cytochrome P450 oxidation, glutathione (GSH) conjugation) may also play an important role in their toxicity.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
KLOB-010 is predicted as suspected carcinogen; the Toolbox profiler carcinogenicity (genotox and nongenotox) alerts by ISS gives an alert for carcinogenicity (Aliphatic halogens (Genotox)).
Predictions on carcinogenicity obtained by Vega and Danish EPA models are not reliable.
Overall, available data are inconclusive for the classification of the substance
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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