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EC number: 235-868-1 | CAS number: 13014-18-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1986-10-14 to 1986-12-09
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
Test material
- Reference substance name:
- 2,4-Dichlorobenzotrichloride
- IUPAC Name:
- 2,4-Dichlorobenzotrichloride
- Reference substance name:
- 2,4-dichloro-1-(trichloromethyl)benzene
- EC Number:
- 235-868-1
- EC Name:
- 2,4-dichloro-1-(trichloromethyl)benzene
- Cas Number:
- 13014-18-1
- Molecular formula:
- C7H3Cl5
- IUPAC Name:
- 2,4-dichloro-1-(trichloromethyl)benzene
- Test material form:
- solid: crystalline
- Details on test material:
- Please refer to confidential details on test material
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: HOECHST AG, Kastengrund, SPF-Zucht
- Age at study initiation: male ca. 7 wks, female ca. 8 wks
- Weight at study initiation: males 169 g - 202 g (average 188 g); females: 178 g - 195 g (average 195 g)
- Fasting period before study: about 16 hours
- Housing: 5 animals per makrolon cage
- Diet: Altromin 1324 rat diet, ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 3
- Humidity (%): 50 +/- 20
- Air changes (per hr): no data
- Photoperiod: 12 hrs dark / 12 hrs light
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sesame oil
- Details on oral exposure:
- Maximum dose volume applied: 10 mL/kg bw
- Doses:
- 1000, 1250, 1400, 1600, 1800, 2000, 2500 mg/kg bw
- No. of animals per sex per dose:
- 1000, 1250, 1400 mg/kg bw: 5 males
1800, 2000 mg/kg bw: 5 females
1600, 2500 mg/kg bw: 5 males and 5 females - Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of weighing: weekly
- Necropsy of survivors performed: yes, macroscopical examination
- Other examinations performed: clinical signs - Statistics:
- LD50 Evaluation; 95% confidence interval
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 320 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 841 - 1 550
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 700 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 961 - 2 040
- Mortality:
- 1000 mg/kg bw: 0/5 male animals
1250 mg/kg bw: 2/5 male aninmals
1400 mg/kg bw: 3/5 male animals
1600 mg/kg bw: 5/5 male animals and 1/5 female animals
1800 mg/kg bw: 4/5 female animals
2000 mg/kg bw: 5/5 female animals
2500 mg/kg bw: 5/5 male animals and 5/5 female animals - Clinical signs:
- other: Coat bristling, cowering posture, decreased activity, respiratory rate increased, irregular respiration, panting, gait stilted, forward crawling, trembling, prone position, paw reflex to pinching negative, palpebral fissure narrow, cear and bloody lacrima
- Gross pathology:
- Animals which died within the study:
liver and spleen brightend, spleen significantly reduced, gastrointestinal tract filled with dark blood.
Animals which survived:
no macroscopical findings.
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of the present aucte oral toxicity study 2,4-Dichlorobenzotrichloride revealed a LD50 value of 1320 mg/kg bw for male and 1700 mg/kg bw for female animals.
Based on the results obtained from testing 2,4-Dichlorobenzotrichloride has to be classified as category 4, H302 (harmful if swallowed) according to Regulation (EC) No 1272/2008 (CLP).
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