Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 429-320-2 | CAS number: 24748-23-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02-06-2017 to 01-09-2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- The competent authority (RIVM and USEPA) have indicated there are concerns with regards to the persistency of the test substance due to conflicting data of biodegradations studies. Therefore the hydrolysis products of 3,6,9-triethyl-3,6,9-trimethyl-1,4,7-triperoxonane have been investigated. Previous studies with organic peroxides have shown them to be influenced by organic matter in the form of Humic acid. Replicates with sterilized natural water and deionized water with humic acid were therefore also investigated.
Sterilised aqueous buffer solutions and test media were spiked with the test substance and incubated (at 12°C) in the dark under controlled laboratory conditions. After appropriate time intervals, buffer solution/test media were analysed to try to identify and quantify the formed hydrolysis products. - Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Version / remarks:
- Tier 3
- Deviations:
- yes
- Remarks:
- see Principles of method if other than guideline
- Principles of method if other than guideline:
- There were four modifications to OECD guideline 111:
· No thymol was added to the buffer solutions as, based on microbiological experience, the addition of
thymol as a disinfectant is not necessary because the buffer solutions were sterilized also.
· Test temperature of 12 °C was used. As it was the goal to determine the hydrolysis products at
environmental relevant temperatures.
· In addition to the standard OECD guideline buffers, a natural surface water and demineralized water
containing humic acid was tested. The test was performed above the water solubility, this was
necessary to ensure that sufficient hydrolysis product would be generated, to make identification and
quantification possible.
· Test was conducted using techniques not readily available in contract laboratories and was therefore
not conducted to GLP. - GLP compliance:
- yes
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Buffers:
- Buffer solutions were prepared according to the buffer systems as described in Annex 3 of OECD
guideline 111 (OECD, 2004). - Details on test conditions:
- De-ionised water
The de-ionised water used in the study contained less than 10 μg/L of copper (not measured under
GLP), with a conductivity of less than 5 μS/cm and less than 2.0 mg/L NPOC-content.
Materials
Test vessels, buffer solution and test media were sterilised. Test solutions were flushed with nitrogen to
minimise oxidation. Test vessels were kept under dark conditions. A temperature-controlled water bath
was used; temperature was measured using a calibrated thermometer, pH was measured using a pH
meter. The pH buffer 7 was made according to the description of Clak and Lubs, described in Annex 3
of OECD 111 (OECD, 2004). The natural surface water was sampled in the Netherlands
Identification of hydrolysis products (Tier 3)
The sterilised buffer solution pH 7, the surface water and demineralized water containing humic acid
were transferred to volumetric flaks and purged with nitrogen for at least 5 minutes.
A stock solution of the test substance was prepared in dichloromethane and spiked to the buffer
solution and the two other media. The solutions were spiked in 50 mL volumetric flasks at a
concentration of approximately 25 mg/L, not exceeding 1 % (v/v) of solvent. Subsequently 10 mL of the
spiked solutions was transferred to multiple sterile glass test vials. The vials were closed tightly and
placed in a thermostatically controlled water bath in the dark at a temperature of 12 ± 0.5°C. At the
moment the test vials were placed in the water bath, the first sample was taken and analyzed using the
analytical methods described in annex 3. Subsequent samples were taken on different time intervals
and analyzed to determine which and the amount of hydrolysis products formed. Samples were
analyzed directly after sampling in order to prevent further hydrolysis and/or thermal decomposition. In
order to ensure that sufficient hydrolysis product would be generated, to make quantification possible,
the water solubility limit was exceeded. - Duration:
- 90 d
- pH:
- 7
- Temp.:
- 12 °C
- Transformation products:
- no
- Remarks:
- no expected or unknown transformation products were seen to increase in concentration during the course of the study
- Details on hydrolysis and appearance of transformation product(s):
- At the start of the test, next to the test substance, the following products were already percent; MEK (methyl ethyl ketone), acetic acid and MEK type 3. These products are also the expected hydrolysis products. The concentrations of these products were followed during the course of this study, however as the concentrations of these products did not increase significantly, supported by the lack of new products being formed and the Trigonox 301 concentration not decreasing significantly, it was concluded that no hydrolysis products were formed during the 90 day test period at 12 °C.
- pH:
- 7
- Temp.:
- 12 °C
- DT50:
- > 90 d
- Remarks on result:
- hydrolytically stable based on preliminary test
- Validity criteria fulfilled:
- yes
- Remarks:
- Test temperatures were measured to be within the criteria (12.0 +/- 0.5 oC); the pH value of the buffer pH 7 was measured to be within the criteria (7 +/- 0.1)
- Conclusions:
- Existing hydrolysis data was brought into question due to the lack of biodegradation and the discrepancies between the test substance and its analogues. Due to this data being critical to the
interpretation of the persistence of the test material an environmentally relevant data point showing apparent rapid hydrolysis in existing data (Harlan 2014) was selected for a repeat and identification of hydrolysis products.
The purpose of this study was to determine the hydrolysis products of 3,6,9-triethyl-3,6,9-trimethyl- 1,4,7-triperoxonane at pH 7 , according to Tier 3 of OECD Guideline No. 111, at a single
environmentally relevant temperature. In addition to the standard buffer solution, the hydrolysis products were also determined in media containing organic material as this has for some peroxide
groups influenced stability. No significant increase in hydrolysis products were detected during the course of this 90 day study. The presence of organic material, addition of an iron complex or elevating the temperature had no effect on the stability of the test substance. - Executive summary:
No significant increase in hydrolysis products were detected during the course of this 90 day study. The presence of organic material, addition of an iron complex or elevating the temperature had no effect on the stability of the test substance.
Reference
Description of key information
The results of an OECD 111 Tier 3 test indicate that at a pH value of 7, the half-life (t½) for 3,6,9-Triethyl-3,6,9-trimethyl-1,4,7-triperoxonane at a temperature of 12°C was > 90 days.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.