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EC number: 287-484-9 | CAS number: 85536-04-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Remarks:
- Summary of available data used for the endpoint assessment of the target substance.
- Adequacy of study:
- key study
- Justification for type of information:
- Refer to the analogue approach justification provided in IUCLID section 13.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 68.1
- Sampling time:
- 29 d
- Remarks on result:
- other: bottle A
- Remarks:
- Source: RA-A, CAS 93803-87-3, Notox, 1998
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 71.7
- Sampling time:
- 29 d
- Remarks on result:
- other: bottle B
- Remarks:
- Source: RA-A, CAS 93803-87-3, Notox, 1998
- Parameter:
- % degradation (O2 consumption)
- Value:
- 90
- Sampling time:
- 28 d
- Remarks on result:
- other: mean of all replicates
- Remarks:
- Source: RA-A, CAS 101227-09-2, Henkel, 2001
- Conclusions:
- The target substance is readily biodegradable based on experimental studies with two structurally and chemically closely related source substances (66.1 - 71.7% in 29 d, OECD 301 B, 90% in 28 d, OECD 301 D); read-across
Reference
Description of key information
Readily biodegradable (90% in 28 d, ISO 10708; 68.1 - 71.7% in 28 d, OECD 301B); read-across
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
There are no studies available, in which the ready biodegradability of the target substanceFatty acids, C16-18, stearyl esters (CAS 85536-04-5) was assessed.Therefore, the data requirements for this endpoint were met by (Q)SAR prediction (VEGA v1.2.3) in combination with read-across to the two structurally and chemically closely related source substances Fatty acids, C16-18, 2-hexyldecyl esters (CAS 101227-09-2) and 2-octyldodecyl isooctadecanoate (CAS 93803-87-3). Read-across was conducted in accordance with Regulation (EC) No. 1907/2006 Annex XI, 1.5. The source substances are characterized by similar fatty acid chain lengths and alcohol components as the target substance and are therefore considered suitable representatives for the assessment of the ready biodegradability of the target substance. A detailed justification of the analogue approach is provided in IUCLID section 13.
The available study with the source substance Fatty acids, C16-18, 2-hexyldecyl esters (CAS 101227-09-2) was conducted according to ISO 10708 (equivalent or similar to OECD 301 D) using activated sludge from a domestic sewage treatment plant as inoculum for 100 mg/L test item (based on ThOD/L). After 28 d, the mean degradation of the test item was 90% based on O2 consumption. Therefore, the substance is readily biodegradable according to the OECD criteria (biodegradation > 60% after 28 d, and the fulfilment of the 14 d window).
The available study with source substance 2-octyldodecyl isooctadecanoate (CAS 93803-87-3) was conducted according to OECD 301 B using domestic activated sludge as inoculum with approx. 14.5 mg/L test item. After 28 d, the substance was degraded by 68.1 - 71.7%. According to ECHA Guidance Chapter R. 7b (2017), the 10-day window does not need to be applied if the test is carried out on a mixture of structurally similar constituents and if it is anticipated that a sequential biodegradation of the individual components is taking place, based on the OECD “Guidelines for the Testing of Chemicals, Revised Introduction To The OECD Guidelines For Testing of Chemicals (Section 3, Part I, OECD, 2006b). Thus, the % degradation at the end of exposure is used instead to assess the ready biodegradability of the substance as a whole. Since degradation was > 60 % after 28 d, the substance is regarded as readily biodegradable.
Furthermore, the (Q)SAR model for ready biodegradability (VEGA v1.2.3, IRFMN 1.0.9) predicts ready biodegradability. The two constituents of the substance lie within the applicability domain of the model and fulfilled all the measured applicability domain scores listed in the attached VEGA report. The overall model performance is very good. Thus, the result appears reliable and is considered adequate for regulatory purposes under REACh regulation (EC) No 1907/2006.
Based on the high degree of structural and chemical similarity between the target and the selected source substances, the target substance is expected to exhibit a similar environmental fate profile as the source substances. Therefore, it is concluded that the target substanceFatty acids, C16-18, stearyl esters (CAS 85536-04-5) is readily biodegradable according to OECD guideline criteria, based on the available experimental results and QSAR prediction.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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