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EC number: 610-949-8 | CAS number: 53045-70-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14.12.2007-11.03.2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 2004
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- Storage of Samples:
The samples were delivered frozen to the IBACON Laboratory. The sample containers were not damaged. All samples were stored in a freezer (- 10 °C), protected from light until analysis was performed.
Fortified Samples:
About 50 mg of the test item were dissolved in 50 mL acetonitrile to obtain a stock solution of I g test item/L, respectively. Appropriate amounts of this stock solution were diluted with test medium to obtain fortified samples at a level of 10 and 100 mg test item/L. Exact values were documented in the raw data. - Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Source: The daphnids introduced in the test were taken from in-house laboratory culture.
- Age of parental stock: <=24 h - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 14°dH (ca. 250 mg/L CaCO3)
- Test temperature:
- 20 - 21°C
- pH:
- 7.84 - 7.91
- Dissolved oxygen:
- 93.9 - 96.8%
- Nominal and measured concentrations:
- Nominal Concentration: 100 mg/L
Measured: 100% at geginning and and 96% of nominal at end of test - Details on test conditions:
- TEST SYSTEM
- Aeration: no
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: according to ELENDT (1990)
OTHER TEST CONDITIONS
- Photoperiod: 16 h light / 8 h dark - Reference substance (positive control):
- no
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- After 48 hours of exposure no immobilisation of the test animals was observed.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 96h-LC50 was determined to be >100 mg/L (nominal).
- Executive summary:
Study design
The objective of this study was to determine the acute toxicity of the test material using Daphnia magna. For this purpose, juvenile Daphnia magna were exposed to an aqueous test material solution over 48 hours, under defined conditions. The study comprised of four test vessels per concentration containing five Daphnia magna each, i.e. 20 Daphnia magna per concentration (test medium group) and control group. Daphnia magna were exposed to a nominal test material concentration of 100 mg/L (limit test) in a closed static system.
Results
The analytical recovery was 100 and 96 % after 0 and 48 hours, respectively. The mean recovery over 48 hours was 98 %. As the stability of the test material in the aqueous solution was ≥ 80 %, the EC50 values were calculated with the nominal concentrations. Nominal, corresponding mean analytical concentrations, and number of immobilized daphnia are given in the following table.
Mean analytical concentration during the study
Immobilized/exposed Daphnia magna
Nominal Concentration [mg/L]
[%]
[mg/L]
24 hours
48 hours
0
-
-
0/20
0/20
100
98
97.6
0/20
0/20
Daphnia magna exposed to an aqueous preparation of the nominal concentration of 100 mg/L of the test item were not affected.
Conclusion
No immobilized daphnids were observed during the test period. The 96h-LC50 was determined to be >100 mg/L.
Reference
Influence of the test material on the Mobility of Daphnia magna
Mean analytical concentration during the study | Immobilized/exposed Daphnia magna | |||
Nominal Concentration [mg/L] | [%] | [mg/L] | 24 hours | 48 hours |
0 | - | - | 0/20 | 0/20 |
100 | 98 | 97.6 | 0/20 | 0/20 |
A nominal concentration of 100 mg/L of the test item revealed no aquatic toxicity in this test system. No remarkable observations were made concerning the appearance of the solution of the test material preparation. The test medium was a clear preparation and stayed unchanged throughout the study.
Description of key information
The 96h-LC50 was determined to be >100 mg/L.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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