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EC number: 402-470-6 | CAS number: 87172-89-2 CINEOLE ALCOHOL
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1986-02-18 to 1986-03-20
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- GLP compliance:
- yes
- Type of study:
- Buehler test
- Justification for non-LLNA method:
- A Buhler test with the test substance is available. The Buhler test has been shown to be sensitive enough to detect moderate to strong sensitisers and is thus considered suitable to address this endpoint.
Test material
- Reference substance name:
- (1S,2S)-1-methyl-4-(propan-2-yl)-7-oxabicyclo[2.2.1]heptan-2-ol
- Cas Number:
- 87172-89-2
- IUPAC Name:
- (1S,2S)-1-methyl-4-(propan-2-yl)-7-oxabicyclo[2.2.1]heptan-2-ol
- Test material form:
- solid
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Hartley
- Sex:
- female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: Charles River Breeding Laboratories, Inc., Wilmington, MA.
- Weight at study initiation: Test group: 413 +/-18; Naive control: 409 +/- 16; Positive control: 402 +/-12
- Housing: The animals were individually housed in wire-mesh cages.
- Diet: NIH Animal Feed A, Zeigler Brothers, Inc., Gardners, PA; ad libitum
- Water: Tap water; ad libitum
- Acclimation period: The animals were acclimated to the laboratory environment for at least 5 days
- Indication of any skin lesions: None
ENVIRONMENTAL CONDITIONS
- Photoperiod (hrs dark / hrs light): 12/12
Study design: in vivo (non-LLNA)
- No. of animals per dose:
- Test group: 10 animals
Positive control: 6 animals
Naive control: 3 animals - Details on study design:
- RANGE FINDING TESTS:
A test item sample was prepared at concentrations of 25, 50 and 75% w/v in mineral oil immediately prior to application and dispensed for dose administration. The test article was also dispensed neat (as received from the Sponsor). Four female guinea gips were exposed once to the test article. No dermal irritation was observed following application of the tested concentrations. Based on the range finding study the test item was dispensed as received from the Sponsor for both the induction and challenge application.
MAIN STUDY
A. INDUCTION EXPOSURE (Day 1, 8, 15)
- No. of exposures: 3
- Exposure period: 6 h; Patches were secured in place after dose administration with an overwrap of Micropore® tape, plastic wrap and a stockinette sleeve. Following the exposure period, the patches were removed and any remaining material was gently wiped off with a clean gauze.
- Test groups: 10 animals (see table 1 for details).
- Control group:
Positve control: 6 female animals were exposed to DNCB (see table 1 for details).
Naive control: 3 additional animals serve as naive controls at the challenge (see table 1 for details).
- Site: Clipped back of the animals
- Frequency of applications: Once a week
- Concentrations: 0.5 g of the test item
B. CHALLENGE EXPOSURE (Day 29)
- No. of exposures: Single application
- Day of challenge: 29
- Exposure period: 6 h; Patches were secured in place after dose administration with an overwrap of Micropore® tape, plastic wrap and a stockinette sleeve. Following the exposure period, the patches were removed and any remaining material was gently wiped off with a clean gauze.
- Test groups: 10 animals (see table 1 for details).
- Control group:
Positve control: 6 female animals were exposed to DNCB (see table 1 for details).
Naive control: 3 additional animals serve as naive controls at the challenge (see table 1 for details).
- Site: Dorsal virgin skin sites
- Concentrations: 0.5 mL
OTHER:
Daily observations and dermal response evaluation:
All animals were observed daily for signs of toxicity and overt behavioral changes. Mortality checks were conducted twice daily, at least five hours apart. The application sites were examined for erythema and edema at 24 and 48 hours post-induction and challenge applications. Erythema and edema were scored according to the Draize method. - Positive control substance(s):
- yes
- Remarks:
- 1-chloro-2,4-dinitrobenzene (DNCB)
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 0.5 g of the test item
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Remarks on result:
- other: Edema and Erythema Score; For details see table 1
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 0.5 g of the test item
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Remarks on result:
- other: Edema and Erythema Score; For details see table 1
Any other information on results incl. tables
Daily observation and body weight:
One animal exhibited soft stools during the study. All other animals appeared normal throughout the study period.
All animals gained weight during the study.
Induction Application:
Very slight (Draize score = 1) erythema was noted for one test article-treated animal following induction application two.
DNCB-treatment caused dermal irritation which was characterized by erythema. Individual erythema scores within this treatment group increased from none (0) to well-defined (2) after three applications. Slight (1) edema was observed in two DNCB-treated animals following induction application 3.
Challenge:
No irritation was noted in the test or naive animals following the challenge application. This response was significantly greater (p<=0.05) than the response obtained after the first induction application. Slight (1) edema was also observed following the challenge application of DNCB in one of the six animals.
Table 1: Summary of Dermal Response - Edema
Group |
Application |
Mean Edema Score |
|
24 h |
48 h |
||
Test |
Induction 1 |
0 |
0 |
Induction 2 |
0 |
0 |
|
Induction 3 |
0 |
0 |
|
Challenge |
0 |
0 |
|
Naive Control |
Challenge |
0 (3) |
0 (3) |
Positive Control |
|
|
|
DNCB (0.1% in 70% ethanol) |
Induction 1 |
0 (6) |
0 (6) |
DNCB (1.0% in 70% ethanol) |
Induction 1 |
0 (6) |
0 (6) |
Induction 2 |
0 (6) |
0 (6) |
|
Induction 3 |
0.3±0.5 (6) |
0.2±0.4 (6) |
|
DNCB (0.1% in 70% ethanol) |
Challenge |
0 (6) |
0.2±0.4 (6) |
70% ethanol |
Challenge |
0 (6) |
0 (6) |
Values are group mean±S.D. of scores read at 24 and 48 hours post-administration for 10 animals except where indicated in ()
Table 2: Summary of Dermal Response - Erythema
Group |
Application |
Mean Erythema Score |
|
24 h |
48 h |
||
Test |
Induction 1 |
0 |
0 |
Induction 2 |
0 |
0.1 ±0.3 |
|
Induction 3 |
0 |
0 |
|
Challenge |
0 |
0 |
|
Naive Control |
Challenge |
0 (3) |
0 (3) |
Positive Control |
|
|
|
DNCB (0.1% in 70% ethanol) |
Induction 1 |
0 (6) |
0 (6) |
DNCB (1.0% in 70% ethanol) |
Induction 1 |
1.2±0.4 (6) |
1.2±0.4 (6) |
Induction 2 |
1.0 ± 0 (6) |
1.0±0 (6) |
|
Induction 3 |
1.8±0.4 (6) |
1.8±0.4 (6) |
|
DNCB (0.1% in 70% ethanol) |
Challenge |
1.7 a±0.5 (6) |
1.5 a±0.5 (6) |
70% ethanol |
Challenge |
0 (6) |
0 (6) |
Values are group mean±S.D. of scores read at 24 and 48 hours post-administration for 10 animals except where indicated in ()
a Significantly different from induction application 1 (p≤0.05)
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of this Buehler test, the test substance did not cause dermal contact sensitisation in female albino guinea pigs.
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