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Key value for chemical safety assessment

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There are no specific toxicokinetic data available for dibenzyl toluene (DBT). However, based on the chemical structure and the physico-chemical properties of the material basic toxicokinetic properties can be estimated. The water solubility of DBT is low. The logPow is > 6. Since only dissolved material is likely to be absorbed in the gastrointestinal tract, water solubility might be the limiting factor. Due to the higher low Pow the material might absorb to proteins. Nevertheless, based on structural considerations, as well as systemtic effects observed in animal experiments with oral application it can reasonably be assumed that absorption via the gastrointestinal tract does occur. No data for dermal absorption are available. Due to the higher lipophilicity a lower penetration through the skin is expected.

Once absorbed via the gastrointestinal tract it is likely that the material will be distributed systemically. No high first pass effect in the liver is expected due to lack of functional groups, which are only introduced by enzymatic reactions. Data from in vitro experiments indicate metabolic pathways via oxidation and demethylation reactions. Overall, the resulting metabolic intermediates are more soluble and/or include functional groups that enable further elimination via phase 2 reactions (e.g. glucuronidation, sulfation). Hence, despite the relatively high lipophilicity a bioaccumulation in fatty tissues is not expected.