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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2015-03-08 to 2015-03-13
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method C.3 (Algal Inhibition test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 850.5400 (Algal Toxicity, Tiers I and II) (January 2012)
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: The saturated solution and further four dilution levels out of the saturated solution were tested in a geometrical series with a dilution factor of 2: 6.25 - 12.5 - 25.0 - 50.0 - 100 % of the saturated solution, corresponding to the nominal loading rates 0.313 - 0.625 - 1.25 - 2.50 - 5.00 mg/L. The loading levels are based on a proposal of the sponsor.
- Sampling method: The test concentrations of Disperse Yellow DYLA 1306 were analytically verified via HPLC-UV in the saturated solution and the control at the start of the exposure (0 hours). At the start of the exposure (0 hours), sampling was carried out after preparation of the loading levels.
As the measured test item concentration was below the LOQ in the saturated solution, the test item concentrations at the other loading levels were considered to be also below the LOQ. At the end of the exposure (96 hours), no analytical monitoring was carried out, because a measured test item concentration above the LOQ was not observed at the start of the exposure.
The method was validated prior to this study according to SANCO 3029/99 rev.4 (2000). - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: The saturated solution with a nominal loading of 5.00 mg/L was prepared once with dilution water. The saturated solution was stirred for 24 hours (1100 rpm) at room temperature with a magnetic stirrer. After 24 hours undissolved particles were removed by membrane filtration (membrane filter 0.2 µm, RC, MACHEREY-NAGEL). The filtrate was clear and yellow-orange.
- Differential loading: The saturated solution and further four dilution levels out of the saturated solution were tested in a geometrical series with a dilution factor of 2: 6.25 - 12.5 - 25.0 - 50.0 - 100 % of the saturated solution, corresponding to the nominal loading rates 0.313 - 0.625 - 1.25 - 2.50 - 5.00 mg/L. The loading levels are based on a proposal of the sponsor.
- Dilution water: Threefold concentrated AAP medium according to the guidelines
-Controls: Eight replicates (without test item) were tested under the same test conditions as the test item groups. - Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
- Details on test organisms:
- TEST ORGANISM
- Common name: Pseudokirchneriella subcapitata HINDÁK
- Strain: SAG 61.81
- Source (laboratory, culture collection): SAG Pflanzenphysiologisches Institut der Universitaet Goettingen, Nikolausberger Weg 18, D-37073 Goettingen, Germany
- Age of inoculum (at test initiation): 3 days
- Method of cultivation: Fresh stocks were prepared from Z-Agar. Light intensity amounted 35 - 70 µE x m-2 x s-1 for 24 hours per day.
ACCLIMATION
- Culturing media and conditions (same as test or not): Not the same, Nutrient medium Z according to LÜTTGE et al. (1994)
- Any deformed or abnormal cells observed: No - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Post exposure observation period:
- None
- Hardness:
- Not measured
- Test temperature:
- Mean: 24.4 °C, Min: 23.8°C, Max: 25.0 °C
- pH:
- Nominal test item
loading rate pH-value
[mg/L] Start; 0 hours End; 96 hours
5.00 7.49 9.90
2.50 7.46 9.89
1.25 7.45 9.84
0.625 7.46 9.90
0.313 7.49 9.88
Control 7.46 9.96 - Dissolved oxygen:
- Not measured
- Salinity:
- Not measured, freshwater
- Nominal and measured concentrations:
- Please refer to information on materials and methods
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 250 mL Erlenmeyer flasks (sterile)
- Type (delete if not applicable): sealed with cotton wool plugs
- Material, size, headspace, fill volume: sterile 250 mL Erlenmeyer flasks, test volume 100 mL
- Agitation: Test containers were placed on a rotary shaker and oscillated at appr. 100 rpm
- Type of flow-through (e.g. peristaltic or proportional diluter): None
- Renewal rate of test solution (frequency/flow rate): One application at test start
- Initial cells density: 10010 cells/mL
- Control end cells density: Mean 5142808 cells/mL
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 8
- No. of vessels per vehicle control (replicates): None
GROWTH MEDIUM
- Standard medium used: Yes
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Threefold concentrated AAP medium according to the guidelines
Composition of Dilution water (OECD)
Component Concentration [mg/L]
NaNO3 76.5
MgCl2 6 H2O 36.492
CaCl2 2 H2O 13.23
MgSO4 7 H2O 44.1
K2HPO4 3.132
NaHCO3 45
H3BO3 0.5565
MnCl2 4 H2O 1.246
ZnCl2 9.81 x 10-3
CoCl2 6 H2O 4.29 x 10-3
CuCl2 2 H2O 0.036 x 10-3
NaMoO4 2 H2O 21.78 x 10-3
FeCl3 6 H2O 0.4794
Na2-EDTA 0.9
pH 7.5 0.1
The pH of the test medium has to be 7.5 0.1 and was adjusted prior to testing with addition of 1 M NaOH and HCl.
OTHER TEST CONDITIONS
- Sterile test conditions: no
- Adjustment of pH: no
- Photoperiod: 24 h
- Light intensity and quality:35 - 45 µE x m-2 x s-1 (nominal), mean: 42.4 µE x m-2 x s-1, measured values: 37.2 - 44.9 µE x m-2 x s-1 (measured, n = 32, CV = 5.19%)
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
- Determination of cell concentrations: The cell density was measured daily via Chlorophyll a fluorescence, excitation at 436 nm, emission at 685 nm. Dilution water was used as background signal. No self-fluorescence was found in the definitive test at the nominal loading level of 100 % of the saturated solution.
TEST CONCENTRATIONS
- Range finding study: None
- Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
- Duration:
- 72 h
- Dose descriptor:
- NOELR
- Effect conc.:
- >= 5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Duration:
- 72 h
- Dose descriptor:
- NOELR
- Effect conc.:
- >= 5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- yield
- Duration:
- 72 h
- Dose descriptor:
- NOELR
- Effect conc.:
- >= 5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- LOELR
- Effect conc.:
- > 5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Biomass, Growth Rate, Inhibition of Yield
- Duration:
- 72 h
- Dose descriptor:
- EL10
- Effect conc.:
- > 5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Biomass, Growth Rate, Inhibition of Yield
- Duration:
- 72 h
- Dose descriptor:
- EL20
- Effect conc.:
- > 5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Biomass, Growth Rate, Inhibition of Yield
- Duration:
- 72 h
- Dose descriptor:
- EL50
- Effect conc.:
- > 5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Biomass, Growth Rate, Inhibition of Yield
- Duration:
- 96 h
- Dose descriptor:
- NOELR
- Effect conc.:
- >= 5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Duration:
- 96 h
- Dose descriptor:
- NOELR
- Effect conc.:
- >= 5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 96 h
- Dose descriptor:
- NOELR
- Effect conc.:
- >= 5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- yield
- Duration:
- 96 h
- Dose descriptor:
- LOELR
- Effect conc.:
- > 5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Biomass, Growth Rate, Inhibition of Yield
- Duration:
- 96 h
- Dose descriptor:
- EL10
- Effect conc.:
- > 5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Biomass, Growth Rate, Inhibition of Yield
- Duration:
- 96 h
- Dose descriptor:
- EL20
- Effect conc.:
- > 5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Biomass, Growth Rate, Inhibition of Yield
- Duration:
- 96 h
- Dose descriptor:
- EL50
- Effect conc.:
- > 5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Biomass, Growth Rate, Inhibtion of Yield
- Details on results:
- - Exponential growth in the control (for algal test): yes
- Observation of abnormalities (for algal test):
- Unusual cell shape: Microscopic evaluation of the cells at the start of the incubation period, after 24, 48, 72 hours and at test end revealed no morphological abnormalities in any test item loading rate or control.
- Colour differences: No
- Flocculation: No
- Adherence to test vessels: No
- Aggregation of algal cells: No
- Other: No
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: No - Results with reference substance (positive control):
- - Results with reference substance valid? Yes
- EC50:
Current Study Valid Range (average ± 3 x SD)
Biomass inhibition
EbC50 0.284 0.442 ± 0.278
95 %
confidence interval 0.236 – 0.327
Growth Rate inhibition
ErC50 0.749 0.821 ± 0.388
95 %
confidence interval 0.715 - 0.788
Yield inhibition
EyC50 0.282 0.429 ± 0.261
95 %
confidence interval 0.239 - 0.318 - Reported statistics and error estimates:
- EC-values and statistical analysis:
As no effects of the test item on biomass, growth rate and yield were observed, EL10-, EL20- and EL50-values were deduced directly from the results.
NOEC/LOEC values:
The NOEL / LOEL was determined by calculation of statistical
significance of biomass integrals, growth rate and yield. As a standard, One Way Analysis of Variance (ANOVA) was used for NOEL/LOEL calculations. When running a One Way Analysis of Variance, a Normality test and an Equal Variance test were done first. The SHAPIRO-WILK-Test was used to test for normally distributed populations. The Levene median test was used for equal variance. P-values for both Normality and Equal Variance tests are 0.05. The -value (acceptable probability of incorrectly concluding that there is a difference) is = 0.05. - Validity criteria fulfilled:
- yes
- Conclusions:
- In this study Disperse Yellow DYLA 1306 was found to not inhibit the growth of the freshwater green alga Pseudokirchneriella subcapitata with the following effect values (nominal test item loading rates): The EL50-values for inhibition of biomass (EbL50), growth rate (ErL50) and yield (EyL50) after 72 hours were > 5.00 mg/L. The EL50-values for inhibition of biomass (EbL50), growth rate (ErL50) and yield (EyL50) after 96 hours were > 5.00 mg/L. The NOEL-values for inhibition of biomass, growth rate and yield after 72 and 96 hours were 5.00 mg/L.
- Executive summary:
The toxicity of Disperse Yellow DYLA 1306 (batch number:EAG-146-1.0.0) to the unicellular freshwater green alga Pseudokirchneriella subcapitata was determined according to the principles of OECD 201, Commission Regulation (EC) No. 761/2009,C.3 and EPA Guideline 712-C-006: OCSPP 850.4500 at Dr.U.Noack-Laboratorien in 31157 Sarstedt, Germany from 2015-03-08 to 2015-03-13 with the definitive exposure phase fom 2015-03-09 to 2015-03-13.The aim of the study was to assess the effects on growth rate and yield over a period of 96 hours.
The study was conducted under static conditions with an initial cell density of 10010 cells/mL. The saturated solution and further four dilution levels were tested in a geometrical series with a dilution factor of 2:6.25 - 12.5 - 25.0 - 50.0-100 % of the saturated solution, corresponding to the nominal loading rates 0.313 - 0.625 - 1.25 - 2.50 - 5.00 mg/L. Four replicates were tested for each test item loading rate and eight replicates for the control. The environmental conditionswere within the acceptable limits.
No recovery phase was performed, because no loading level was inhibited by more than 50%.
The concentrations of the test item Disperse Yellow DYLA1306 were analytically verified via HPLC-UV at the start of the saturated solution and the control. The recovery rates ofthe test item at the start were below the limit of quantification.
All effect values were based on the nominal loading rates of the test item Disperse Yellow DYLA1306. The results are summarized in the following table:NOEL, LOEL, EL-Values and 95 % Confidence Intervals of Disperse Yellow DYLA 1306
based on nominal test item loading rates
Inhibition of Biomass Integrals
Nominal test item loading rates [mg/L]
0 - 72 hours
0 - 96 hours
NOEL
5.00
5.00
LOEL
> 5.00
> 5.00
EbL10
> 5.00
> 5.00
EbL20
> 5.00
> 5.00
EbL50
> 5.00
> 5.00
Inhibition of Growth Rate
Nominal test item loading rates [mg/L]
NOEL
5.00
5.00
LOEL
> 5.00
> 5.00
ErL10
> 5.00
> 5.00
ErL20
> 5.00
> 5.00
ErL50
> 5.00
> 5.00
Inhibition of Yield
Nominal test item loading rates [mg/L]
NOEL
5.00
5.00
LOEL
> 5.00
> 5.00
EyL10
> 5.00
> 5.00
EyL20
> 5.00
> 5.00
EyL50
> 5.00
> 5.00
Reference
Cell Densities (Nominal test item loading rates)
Nominal test item loading rate |
Replicate |
Cell density [cells/mL] |
||||
[mg/L] |
No. |
0 hours |
24 hours |
48 hours |
72 hours |
96 hours |
5.00 |
1 |
10010 |
57013 |
401835 |
2043029 |
6039986 |
2 |
10010 |
54805 |
377524 |
2016247 |
5686371 |
|
3 |
10010 |
66860 |
440106 |
2213753 |
6375538 |
|
4 |
10010 |
63545 |
368254 |
2085679 |
5951677 |
|
Mean |
10010 |
60556 |
396930 |
2089677 |
6013393 |
|
2.50 |
1 |
10010 |
60171 |
394810 |
2042903 |
5082879 |
2 |
10010 |
53080 |
366887 |
1973786 |
5129543 |
|
3 |
10010 |
59666 |
351797 |
1986706 |
5105584 |
|
4 |
10010 |
66377 |
402939 |
2017941 |
5678468 |
|
Mean |
10010 |
59824 |
379108 |
2005334 |
5249119 |
|
1.25 |
1 |
10010 |
48414 |
355748 |
1569556 |
3900105 |
2 |
10010 |
51136 |
379318 |
2014993 |
5181350 |
|
3 |
10010 |
67982 |
454394 |
2285504 |
5957823 |
|
4 |
10010 |
75101 |
480072 |
1988713 |
5261882 |
|
Mean |
10010 |
60658 |
417383 |
1964692 |
5075290 |
|
0.625 |
1 |
10010 |
70457 |
453968 |
2293721 |
4811427 |
2 |
10010 |
61767 |
440796 |
2153667 |
5155509 |
|
3 |
10010 |
73797 |
498963 |
2165521 |
5752352 |
|
4 |
10010 |
71379 |
490032 |
2425433 |
5549140 |
|
Mean |
10010 |
69350 |
470940 |
2259586 |
5317107 |
|
0.313 |
1 |
10010 |
60409 |
440031 |
1846653 |
5133682 |
2 |
10010 |
58941 |
395349 |
1935840 |
5325982 |
|
3 |
10010 |
60666 |
462134 |
2468835 |
6154137 |
|
4 |
10010 |
80504 |
496429 |
2392505 |
6560751 |
|
Mean |
10010 |
65130 |
448486 |
2160958 |
5793638 |
|
Control |
1 |
10010 |
47125 |
447394 |
1586804 |
4618500 |
2 |
10010 |
49994 |
386192 |
1708355 |
4590151 |
|
3 |
10010 |
62403 |
488677 |
2029732 |
5471492 |
|
4 |
10010 |
62378 |
460378 |
1988713 |
5005357 |
|
5 |
10010 |
60704 |
597521 |
2054632 |
4908643 |
|
6 |
10010 |
80934 |
627903 |
2716265 |
6182110 |
|
7 |
10010 |
69742 |
492979 |
2306767 |
4908016 |
|
8 |
10010 |
73499 |
485265 |
2415586 |
5458196 |
|
Mean |
10010 |
63347 |
498289 |
2100857 |
5142808 |
Section-by-Section and Average
Specific Growth Rates of the Control Group
(0 – 96 hours)
|
Replicate No. |
Specific growth rate [d-1] |
Mean (0 - 96 hours) |
SD ± |
CV |
Mean CV [%] |
|||
section-by-section |
|||||||||
0 - 24 hours |
24 - 48 hours |
48 - 72 hours |
72 - 96 hours |
||||||
Control |
1 |
1.55 |
2.25 |
1.27 |
1.07 |
1.53 |
0.517 |
33.7 |
33.8 |
2 |
1.61 |
2.04 |
1.49 |
0.988 |
1.53 |
0.434 |
28.4 |
||
3 |
1.83 |
2.06 |
1.42 |
0.992 |
1.58 |
0.470 |
29.8 |
||
4 |
1.83 |
2.00 |
1.46 |
0.923 |
1.55 |
0.476 |
30.6 |
||
5 |
1.80 |
2.29 |
1.24 |
0.871 |
1.55 |
0.624 |
40.3 |
||
6 |
2.09 |
2.05 |
1.47 |
0.822 |
1.61 |
0.596 |
37.1 |
||
7 |
1.94 |
1.96 |
1.54 |
0.755 |
1.55 |
0.563 |
36.3 |
||
8 |
1.99 |
1.89 |
1.61 |
0.815 |
1.58 |
0.533 |
33.8 |
||
|
|
|
Mean |
1.56 |
|
|
|||
|
|
|
SD ± |
0.03 |
|
||||
|
|
|
CV [%] |
1.61 |
|
Microscopic evaluation of the cells at the start of the incubation period, after 24, 48, 72 hours and at test end revealed no morphological abnormalities in any test item loading rate or control. The environmental conditions (pH-value, water temperature, light intensity) were within the acceptable limits
Description of key information
No adverse effects at the limit of solubility
Key value for chemical safety assessment
Additional information
The toxicity of Disperse Yellow DYLA 1306 to the unicellular freshwater green alga Pseudokirchneriella subcapitata was determined according to the principles of OECD 201, Commission Regulation (EC) No. 761/2009,C.3 and EPA Guideline 712-C-006: OCSPP 850.4500.
The aim of the study was to assess the effects on growth rate and yield over a period of 96 hours.
The study was conducted under static conditions with an initial cell density of 10010 cells/mL. The saturated solution and further four dilution levels were tested in a geometrical series with a dilution factor of 2:6.25 - 12.5 - 25.0 - 50.0-100 % of the saturated solution, corresponding to the nominal loading rates 0.313 - 0.625 - 1.25 - 2.50 - 5.00 mg/L. Four replicates were tested for each test item loading rate and eight replicates for the control. The environmental conditionswere within the acceptable limits.
No recovery phase was performed, because no loading level was inhibited by more than 50%.
The concentrations of the test item Disperse Yellow DYLA1306 were analytically verified via HPLC-UV at the start of the saturated solution and the control. The recovery rates ofthe test item at the start were below the limit of quantification.
All effect values were based on the nominal loading rates of the test item Disperse Yellow DYLA 1306.The results are summarized in the following table:
NOEL, LOEL, EL-Values and 95 % Confidence Intervals of Disperse Yellow DYLA 1306
based on nominal test item loading rates
|
Inhibition of Biomass Integrals Nominal test item loading rates [mg/L] |
|
0 - 72 hours |
0 - 96 hours |
|
NOEL |
5.00 |
5.00 |
LOEL |
> 5.00 |
> 5.00 |
EbL10 |
> 5.00 |
> 5.00 |
EbL20 |
> 5.00 |
> 5.00 |
EbL50 |
> 5.00 |
> 5.00 |
|
Inhibition ofGrowth Rate Nominaltest item loading rates [mg/L] |
|
NOEL |
5.00 |
5.00 |
LOEL |
> 5.00 |
> 5.00 |
ErL10 |
> 5.00 |
> 5.00 |
ErL20 |
> 5.00 |
> 5.00 |
ErL50 |
> 5.00 |
> 5.00 |
|
Inhibition ofYield Nominal test item loading rates [mg/L] |
|
NOEL |
5.00 |
5.00 |
LOEL |
> 5.00 |
> 5.00 |
EyL10 |
> 5.00 |
> 5.00 |
EyL20 |
> 5.00 |
> 5.00 |
EyL50 |
> 5.00 |
> 5.00 |
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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