Registration Dossier
Registration Dossier
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EC number: 224-081-9 | CAS number: 4196-89-8
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
2,2-Dimethylpropane-1,3-diyl dibenzoate is an unreactive white or yellowish solid with mild odor and a melting point of 49 °C. It can be considered non inhalable, because it is a waxy solid with a very low vapor pressure of < 0.0001 hPa at 25 °C. In addition 2,2-dimethylpropane-1,3-diyl dibenzoate is nearly insoluble in water (1.16 mg/l).
No compound related adverse effects are reported in a guideline compliant subacute toxicity study and developmental toxicity study up to the limit dose of 1000 mg/kg/day and, consequently, derivation of a DNEL is not required. 2,2-dimethylpropane-1,3-diyl dibenzoate is not classified as irritating to skin and eyes and not sensitising.
Since 2,2-dimethylpropane-1,3-diyl dibenzoate is a solid exposure above the general occupational dust value of 10 mg/m³ should be omitted.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
2,2-Dimethylpropane-1,3-diyl dibenzoate is an unreactive white or yellowish solid with mild odor and a melting point of 49 °C. It can be considered non inhalable, because it is a waxy solid with a very low vapor pressure of < 0.0001 hPa at 25 °C. In addition 2,2-dimethylpropane-1,3-diyl dibenzoate is nearly insoluble in water (1.16 mg/l).
No compound related adverse effects are reported in a guideline compliant subacute toxicity study and developmental toxicity study up to the limit dose of 1000 mg/kg/day and, consequently, derivation of a DNEL is not required. 2,2-dimethylpropane-1,3-diyl dibenzoate is not classified as irritating to skin and eyes and not sensitising.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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