Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 936-276-2 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Additional information
The chemical safety assessment of the target substance focuses on the most critical and bioavailable constituents of the substance which were determined based on the transformation and dissolution study (OECD guidance 29). According to T/D study results, the most soluble and critical components of this substance are lead and zinc.
Lead is classified as carcinogenic, reproduction toxic and it possess repeated dose toxicity via oral and inhalation routes. Since it is also the main constituent of the target substance, it triggers the target substance to be classified as carcinogenic, reproduction toxic and having repeated dose toxicity. Based on the BAF/BCF values of lead it has also bioaccumulation potential to water (1 553 L/kg (wet weight) and soil (0.39 kg/kg (dry weight). Therefore, the chemical safety assessment of the target substance focuses on lead, and the bioaccumulation factors of lead are used as key values when evaluating the bioaccumulation of the target substance in the environment.
In relation to bioaccumulation, the secondary poisoning was considered irrelevant for zinc which is an essential element that is actively regulated within the body of all organisms. Due to the general lack of increased whole body and tissue concentrations at higher exposure levels, the zinc BCF data show generally an inverse relationship to exposure concentrations (McGeer et al 2003). The physiological basis for the inverse relationship of BCF to zinc exposure concentration arises from Zn uptake and control mechanisms. At low environmental zinc levels, organisms are able to sequester and retain Zn in tissues for essential functions. When Zn exposure is higher, aquatic organisms are able to control uptake. There is clear evidence that many species actively regulate their body Zn concentrations, including crustaceans, oligochaetes, mussels, gastropods, fish, amphipods, chironomids by different mechanisms (McGeer et al 2003). The bioaccumulation potential in mammals is also considered low. Based on this, the chemical safety assessment concludes that bioaccumulation potential of zinc is not considered relevant to be evaluated for the target substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
