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EC number: 215-170-3 | CAS number: 1309-42-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19-03-2010 to 15-06-2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
- Specific details on test material used for the study:
- - Name: Magnesium hydroxide
- Batch no. 20BR0026
- CAS No.: 1309-42-8
- Purity: 99.9 %
- Expiry date: 31 January 2012
- Storage Room Temp. in the dark - Water solubility:
- 1.59 mg/L
- Temp.:
- 20.3 °C
- pH:
- 8.3
- Remarks on result:
- other: Flow rate: 24 ml/h
- Water solubility:
- 1.98 mg/L
- Temp.:
- 20.3 °C
- pH:
- 8.3
- Remarks on result:
- other: Flow rate: 12 ml/h
- Key result
- Water solubility:
- 1.78 mg/L
- Temp.:
- 20.3 °C
- pH:
- 8.3
- Remarks on result:
- other: Mean
- Details on results:
- The water solubility of a test substance is specified by the saturation mass concentration of the test substance in water at a given temperature and is expressed in g/l.
The coefficient of variation (CV) (n=5) was < 30 % at both flow rates. The maximum difference (MD) on water solubility was also < 30 %. Therefore, the water solubility of the test substance was given as the mean value of the measurements at both flow rates. No undissolved particles were detected in the eluates using the Tyndall effect. A small test substance response, with a maximum contribution of 5.1 % to the sample concentrations was measured in the blank. - Conclusions:
- Interpretation of results: slightly soluble (0.1-100 mg/L)
The column elution method was chosen for the determination of the water solubility of magnesium hydroxide. The water solubility of the test substance at 20 °C was 1.78 x 10^-3 g total solids/l. The pH of the saturated aqueous samples was 8.3. - Executive summary:
In a GLP guideline study according to OECD 105 and EEC A.6, the water solubility of Magnesium hydroxide was investigated.
Using the column elution method, a water solubility of 1.78 x 10^-3 g total solids/l. was determined at 20 °C using a validated ICP-MS method.
Reference
Preliminary results:
The content of the test substance dissolved in the water sample was < 10 -2 g/l (8.75 mg/l). Therefore the column elution method was selected.
Main study:
The results for the samples taken at a flow rate of 12 and 24 ml/hour are given in Table 1.
Table 1. Water solubility of the test substance
Flow rate (ml/h) |
Sample no. |
Concentration analysed |
pH |
|||||
Individual (10-3g mg/l) |
Individual (10-3g TS/l) |
Mean of concentration obtained at one flow rate |
Mean of concentrations obtained at two flow rates |
|||||
Mean (10-3g TS/l) |
CV (%) |
Mean (10-3g TS/l) |
MD (%) |
|||||
24 |
1 |
0.672 |
1.61* |
1.59 |
1.5 |
1.78 |
22 |
8.3 |
2 |
0.661 |
1.58* |
||||||
3 |
0.652 |
1.52* |
||||||
4 |
0.670 |
1.61* |
||||||
5 |
0.679 |
1.63* |
||||||
6 |
0.671 |
1.61 |
||||||
7 |
0.654 |
1.57 |
||||||
8 |
0.655 |
1.57 |
||||||
9 |
0.654 |
1.57 |
||||||
10 |
0.673 |
1.61 |
||||||
12 |
1 |
1.06 |
2.54* |
1.98 |
3.1 |
8.3 |
||
2 |
0.975 |
2.34* |
||||||
3 |
0.887 |
2.13* |
||||||
4 |
0.867 |
2.08* |
||||||
5 |
0.840 |
2.01* |
||||||
6 |
0.861 |
2.07 |
||||||
7 |
0.838 |
2.01 |
||||||
8 |
0.794 |
1.90 |
||||||
9 |
0.821 |
1.97 |
||||||
10 |
0.815 |
1.95 |
* Since a decreasing concentration was used to measure the first 5 samples, particularly at the flow rate of 12 ml/min, only samples 6-10 were used for calculation of the water solubility. This procedure is described in the water solubility guidelines.
Description of key information
The water solubility of the test substance at 20 °C was 1.78 x 10^-3 g total solids/l. The pH of the saturated aqueous samples was 8.3.
Key value for chemical safety assessment
- Water solubility:
- 1.78 mg/L
- at the temperature of:
- 20 °C
Additional information
The column elution method was chosen for the determination of the water solubility of Magnesium hydroxide. The water solubility of the test substance at 20 °C was 1.78 x 10-3 g total solids/l. The pH of the aqueous samples was 8.3.
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