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EC number: 701-413-5
CAS number: -
Skin irritation: not irritating (OECD 439; GLP compliant)
Eye irritation: not irritating (OECD 405; GLP compliant)
Number of Studies
July 2007 – March 2012
Range of Viabilities
0.7% - 39.7%
Range of ODs
0.590 – 1.680
Table 1: Results after treatment with
silicic acid, zirconium salt, cadmium pigment encapsulated and controls
Absor-bance570 nmTissue 1*
Absor-bance570 nm Tissue 2*
Absor-bance570 nm Tissue 3*
Mean Absor-banceof 3 Tissues
[% of Negative Control]**
* Mean of
two replicate wells after blank correction
absorbance per treatment group [rounded values]: 100 x (meanabsorbancetestitem)/(mean
One reliable in vitro study described by
Heppenheimer (2012) (OECD 439; GLP compliant) is considered to be
reliable without restrictions. The substance was determined to be not
irritating to the skin.
One reliable in vivo study described by
Leuschner (2012) (OECD 405; GLP compliant) is considered to be reliable
without restrictions. The substance was determined to be not irritating
to the eyes.
Reference Heppenheimer (2012) will be used
for classification. The mean relative absorbance (% of the negative
control, correlating with mean tissue viability) after 15 minutes
incubation in the in vitro human skin model test (EpiSkin, according to
OECD 439) was as follows:
Heppenheimer (2012): relative viability =
The classification criteria according
to regulation (EC) 1272/2008 as skin irritant were not met, since the
mean tissue viability was above the threshold for skin irritants of
Leuschner (2012) is considered as the key study for in vivo eye
irritation and will be used for classification. During the study the
test item was applied to one eye of three animals each and the eye
irritation was scored according to the Draize scale. The
corneae, irises and conjunctivae were not affected by instillation of
the test item. Thus, according to Regulation
(EC) 1272/2008 and subsequent amendments the substance will not be
classified as irritating to the eyes.
classification as respiratory irritant is normally covered under the
endpoint specific target organ toxicity- single exposure and repeated
exposure. Please refer to the endpoint summaries on acute toxicity
(endpoint 7.2) for further information.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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