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EC number: 243-900-0 | CAS number: 20592-85-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sediment toxicity
Administrative data
Link to relevant study record(s)
- Endpoint:
- sediment toxicity: short-term
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1995-07-28 to 1995-10-02
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- The study was conducted according to a national standard method, and in compliance with GLP.
- Qualifier:
- according to guideline
- Guideline:
- other: PARCOM guideline. Paris Commission Ring Test protocol (1993)
- Deviations:
- yes
- Remarks:
- sediment criteria grain size (min grain size 63 rather than 90 um), and silt clay fraction (26.9% rather than 5-20%). It is not considered by the authors to have adversely affected the outcome of the test. See below for further details on deviations.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 218 (Sediment-Water Chironomid Toxicity Test Using Spiked Sediment)
- Deviations:
- yes
- Remarks:
- see below for details.
- Principles of method if other than guideline:
- Deviations (contd.):
- no range finding test
- no twilight period
- test substance was not determined in solution - GLP compliance:
- yes
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on sediment and application:
- PREPARATION OF SPIKED SEDIMENT
- Details of spiking: adequate amounts of the test substance were weighed and added to glass mixing jars containing ca. 712.5 g of damp natural sediment (ca. 350 g dry sediment). As the sediment was adjudged to be damp enough already to mix easily, natural seawater was not added. The jars were sealed and rolled. Portions of about 75 ml of the spiked and control sediments were placed in each of 4 replicate test vessels which were carefully topped up to 225 ml with natural seawater so as not to disturb the sediment layer. A slight aeration was started and 5 randomly chosen test animals were introduced to each test vessel.
- Equilibration time: ca. 24 h
- Equilibration conditions: rolled on a roller bank at about 15°C.
- Controls: Natural sediment treated in the same way as the spiked sediments was used as a control. - Test organisms (species):
- Corophium sp.
- Details on test organisms:
- TEST ORGANISM
- Source: Southern shore of Oosterschelde, The Netherlands.
- Details on collection: collected near the intake point where TNO collects its seawater, close to a break in the former sea dike where a trickle of freshwater emerges. The organisms had a length of ca. 5-8 mm. - Study type:
- laboratory study
- Test type:
- static
- Water media type:
- saltwater
- Type of sediment:
- natural sediment
- Limit test:
- no
- Duration:
- 10 d
- Exposure phase:
- total exposure duration
- Post exposure observation period:
- none
- Hardness:
- Not reported
- Test temperature:
- range: from 14.9 to 15.8°C
- pH:
- range: from 7.9 to 8.1
- Dissolved oxygen:
- Lowest value was 7.1 mg/L
- Salinity:
- range: 30.4 to 33.2%o
- Ammonia:
- Not reported.
- Nominal and measured concentrations:
- Nominal concentrations: 100, 320, 1000, 3200 and 10000 of test material per kg dw.
The results are expressed as active acid. Equal to nominal concentrations: 29.1, 93.1, 291, 931 and 2,910 mg active acid/kg dw. - Details on test conditions:
- TEST SYSTEM
- Test container (material, size):glass beakers with a volume of ca. 250 ml.
- Sediment volume (weight): ca. 350 g dry spike sediment
- Aeration: yes
EXPOSURE REGIME
- No. of organisms per container (treatment): 5
- No. of replicates per treatment group: 4
- No. of replicates per control: 4
OVERLYING WATER CHARACTERISTCS
- Type of water: natural sea water
- Source of water (if non-standard medium)
- Location: from the Eastern Scheldt, Netherlands.
- Description of sampling site: unpopulated area
- Filtration: filtered through sand upon arrival and checked for concentration of volatile organic compounds, and mineral oil. Each batch of seawater is also checked for gross pollution before use in a four day test with the crustacean Mysidopsis bahia. Before using the water was filtered over a carbon filter and a 5µm membrane filter.
- Salinity:32%o
SOURCE OF NATURAL SEDIMENT
- Location and description of sampling site: same location as test animals.
CHARACTERIZATION OF SEDIMENT
- Particle size distribution: median grain size 63-125 µm, silt clay <63 µm
- Sediment sieved: yes at 0.5 mm on arrival to remove predators, broken shell and larger particles.
- Total organic carbon (%): total organic matter content 2.8% (weight loss on ignition)
OTHER TEST CONDITIONS
- Photoperiod: 16 h light-8 h dark regime with transition periods of 30 minutes.
EFFECT PARAMETERS MEASURED (with observation intervals if applicable): mortality, recorded on day 5 and on day 10
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 3 - Reference substance (positive control):
- no
- Duration:
- 10 d
- Dose descriptor:
- LC50
- Effect conc.:
- > 2 910 mg/kg sediment dw
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality
- Duration:
- 10 d
- Dose descriptor:
- LC50
- Effect conc.:
- > 10 000 mg/kg sediment dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 10 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 2 910 mg/kg sediment dw
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality
- Details on results:
- - Mortality of test animals at end of exposure period: max 10% average, see Table 1 for details.
- Behavioural abnormalities: the animals are said by the authors to have a condition (general behaviour) equal to that of the control animals. - Reported statistics and error estimates:
- Since mortalities were within 10% (average) no statistical analysis was generated.
- Validity criteria fulfilled:
- yes
- Conclusions:
- A realiable 10 day LC50 value of >10,000 mg test substance/kg dw, equivalent to >2,910 mg active acid/kg dw, has been determined for the effects of the test substance on mortality of the marine sediment dwelling organism Corophium sp..
Reference
Table 1: Effect of the test substance on mortality of Corophium sp.
Nominal concentration (mg/kg dw) |
Day 5 |
Day 10 |
|||
No. |
% mortal. |
No. |
% mortal. |
||
Control |
Replicate #1 |
5 |
0 |
5 |
0 |
Replicate #2 |
5 |
0 |
4 |
20 |
|
Replicate #3 |
5 |
0 |
5 |
0 |
|
Replicate #4 |
5 |
0 |
4 |
20 |
|
100 |
Replicate #1 |
5 |
0 |
5 |
0 |
Replicate #2 |
5 |
0 |
5 |
0 |
|
Replicate #3 |
5 |
0 |
5 |
0 |
|
Replicate #4 |
5 |
0 |
5 |
0 |
|
320 |
Replicate #1 |
5 |
0 |
5 |
0 |
Replicate #2 |
5 |
0 |
5 |
0 |
|
Replicate #3 |
5 |
0 |
4 |
20 |
|
Replicate #4 |
5 |
0 |
5 |
0 |
|
1000 |
Replicate #1 |
5 |
0 |
5 |
0 |
Replicate #2 |
5 |
0 |
4 |
20 |
|
Replicate #3 |
5 |
0 |
4 |
20 |
|
Replicate #4 |
5 |
0 |
5 |
0 |
|
3200 |
Replicate #1 |
5 |
0 |
5 |
0 |
Replicate #2 |
5 |
0 |
4 |
20 |
|
Replicate #3 |
5 |
0 |
4 |
20 |
|
Replicate #4 |
5 |
0 |
5 |
0 |
|
10,000 |
Replicate #1 |
5 |
0 |
5 |
0 |
Replicate #2 |
5 |
0 |
5 |
0 |
|
Replicate #3 |
5 |
0 |
5 |
0 |
|
Replicate #4 |
5 |
0 |
5 |
0 |
Result expressed as nominal concentration. Properties of the
test substance and evidence from other studies (where
concentrations were measured) indicate that nominal and
measured concentrations are likely to be in good agreement.
Description of key information
Supporting study: A 10-day LC50 value of >2910 mg active acid/kg dw has been determined for the effects of ATMP-H on mortality of the marine sediment dwelling organism Corophium sp.
Supporting study: a 10-day LC50 value of >5000 mg/kg dw has been determined for the effects of ATMP-H on the mortality of the marine sediment dwelling organism, Corophium volutator.
Key value for chemical safety assessment
Additional information
There are no long-term data available for sediment dwelling organisms.
In a supporting short-term sediment toxicity test, a 10-day LC50 value of >2910 mg active acid/kg dw has been determined for the effects of ATMP-H on mortality of the marine sediment dwelling organism Corophium sp. (TNO, 1997).
In a supporting short-term sediment toxicity test, a 10-day LC50 value of >5000 mg /kg dw, nominal concentratrion, has been determined for the effects of ATMP-H on mortality of the marine sediment dwelling organism Corophium volutator (Zeneca, 1995).
No test data are currently available for freshwater sediment-dwelling organisms.
In accordance with Column 2 of REACH Annex X, there is no need to further investigate the effects of this substance to sediment dwelling organisms because, as indicated in REACH guidance R7b Section R.7.8.14 (ECHA, 2017), the quantitative chemical safety assessment (conducted according to Annex I of REACH) indicates that the Risk Characterisation Ratio is below 1, therefore the risk is already adequately controlled and further testing is not justifiable. An additional factor of 10 is applied to the screening assessment when undertaking risk characterisation based on equilibrium partitioning PNEC for sediment for substances which have log Kow >5. This is to account for additional exposure via ingestion of adsorbed substance on particles and it is therefore scientifically appropriate to consider making a similar adjustment for substances which have binding or adsorption properties indicating highly adsorbing behaviour, equivalent to a high log Kow. Phosphonates are highly adsorbing even though the log Kow value is extremely low, as discussed in IUCLID Section 5.4. In view of the tendency to bind irreversibly to the inorganic substrate; the generalised lack of uptake and rapid clearance from the body associated with oral exposure, and low bioaccumulation potential, these are strong arguments against a need to make such an adjustment to RCR values. On this basis, the extra factor of 10 is not applied in this assessment. The substance is involatile and highly adsorbing and low toxicity was observed in short and long-term aquatic tests, and there is no reason to expect effects in the sediment compartment that were not expressed in the aquatic compartment. The phosphonate ligand binds strongly and irreversibly to various minerals present in sediment and so bioavailability to sediment organisms is extremely limited. The PNEC calculated by Equilibrium Partitioning has been derived for the purpose of conducting a chemical safety assessment, and the risk characterisation ratios are below 1. Furthermore, results are available for short-term effects on marine sediment-dwelling organisms. A reliable 10-day LC50 value of >2910 mg active acid/kg d.w. has been determined for the effects of ATMP-H on mortality of Corophium sp. A second result of >5000 mg/kg d.w. is also available. The results indicate that ATMP acid has low toxicity to sediment-dwelling organisms following short-term exposure. Details on how the PNEC and the risk characterisation ratio have been derived can be found in IUCLID Section 6.0 Ecotoxicological Information and Chapters 9 and 10 of the Chemical Safety Report, respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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