Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-149-6
CAS number: 78-84-2
Isobutyraldehyde did not cause ear swelling or cell proliferation in a
combined MEST and radioisotopic assay.
NTP 1990 reported a study, where
isobutyraldehyde was tested on female B6C3F1 mice. The doses of
isobutyraldehyde ranged from 3% to 30% in a solution of 4 parts acetone
to one part olive oil (4:1) for induction and 30% for challenge. Mice
received 20 µL by direct dermal application for 5 consecutive days to a
shaved and dermabraded site. DNFB (1-fluoro-2,4-dinitrobenzene) (98%)
was used as a positive control at a concentration of 0.5%. Measurement
of the contact hypersensitivity was accomplished by the radioisotopic
assay and the mouse ear swelling test (MEST). No statistically
significant dose-dependent contact hypersensitivity response to
isobutyraldehyde was demonstrated in mice with or without adjuvant.
Based on the available information
classification for skin sensitisation is not warranted in accordance
with EU Classification, Labeling and Packaging of Substances and
Mixtures (CLP) Regulation No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Niniejsza strona używa plików cookies, aby zapewnić optymalne korzystanie z naszych stron internetowych.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again