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EC number: 201-149-6
CAS number: 78-84-2
The LD50 for acute oral toxicity was determined to be 3730 mg/kg bw.The LC50 for acute inhalation toxicity was determined to be above 23.6 mg/L air after a 4 hour exposure.The LD50 for acute dermal toxicity was determined to be 5583 mg/kg bw.
Acute toxicity: oral
Smyth et al. (1954) reported an oral
toxicity study in which five female Carworth Wistar per dose were
exposed to the test substance. Based upon mortalities during a 14-day
observation period, the most probable LD50 value and its fiducial range
are estimated by the method of Thompson using the tables of Weil.
Animals were exposed to 2000, 3980 and 7950 mg/kg bw dissolved in 1%
solution of sodium 3,9-diethyl-6-tridecanol sulfate (Tergitol Penetrant
7). Severe gastrointestinal tract necrosis was observed. The liver,
spleen and kidneys were necrotic at the parts where they contacted the
stomach wall. Lungs were markedly congested or hemorrhagic. The LD50 was
determined to be 3730 (2680 – 5210) mg/kg bw. This is supported by the
LD50 value cited in Industrial
hygiene and toxicology (Fassett, 1962), which was between 1600 and
3200mg/kg in rats. No further information was provided.
Acute toxicity: inhalation
Smyth et al. (1954) reported an
inhalation toxicity study, in which 6 male rats were exposed to 8000 ppm
and 16000 ppm of the test substance for 4 hours. Animals were observed
for 14 days. 1 of the 6 animals died at the lower concentration, while
all animals died after exposure to 16000ppm. The LC50 was determined to
be above 8000 ppm, which is equivalent to 23.6 mg/L. This value is
supported by a Russian publication (Solotov 1972), in which the LC50 for
mice is given as 39.5mg/L after exposure for 2h.
In an inhalation hazard test (BASF
1958) performed according to BASF-internal standards, three groups of 6
rats, were exposed to a saturated atmosphere of the test substance for
2, 8, and 30 min. Mortality in each group was recorded and surviving
rates were observed for another 14 days. After 2 min exposure, no
mortality occurred. After 8 min exposure 3/6 animals died and after 30
min exposure all animals died (death occurred 8-17 minutes after the
start of exposure). Based on a vapour pressure of 230.65 hPa, the
saturated vapour pressure was calculated to be 671 mg/L. Smyth et al.
(1954) also reported a study in which six male albino rats per group
were exposed to a flowing steam of air approaching saturation with
vaporized isobutyraldehyde. One group was exposed for 15 min and the
other for 30 min. 4 out 6 rats exposed for 30 min died, and 0 out of 6
rats exposed for 15 min died. In an article published by Salem et al.
(1960) fifty mice, twenty guinea pigs and five rabbits were exposed to
the aerosol form of the test substance for ten hours. Animals were
exposed to 8967 mg/m3. The mean fatal dose was determined to be 14.5,
26.2, 22.7 mg x min/m3, respectively. Considering the low concentrations
compared to the saturated vapour concentration, exposure solely to
aerosol is unlikely.
Animals exposed to the saturated
vapors (BASF, 1958 and Smyth, 1954) were only exposed for short periods
of time to very high concentrations, which do not permit the calculation
of LC50 values. The animals in the study of Salem (1960) were exposed
for 10 hours presumably to an aerosol-vapour mixture and the LC50 was
not determined. The study by Smyth et al. (1954) is therefore considered
most reliable to determine the LC50 value. It is above 23.6 mg/L but
below 47.2 mg/L for vapor exposure of 4 hours, which fits the reported
LC50 for mice of 39.5mg/L after 2h exposure.
Acute toxicity: dermal
In a study performed by Smyth et al.
(1954) penetration of rabbit skin is estimated by a technique closely to
the one-day cuff method of Draize and associates, using male New-zealand
White rabbits. The fur was removed from the entire trunk by clipping,
and the dose was retained beneath an impervious plastic film. The
animals were immobilized during the 24-hour contact period, after which
the film was removed and the rabbits were caged for the subsequent 14
-day observation period. Two and four animals were exposed to 5 or 10
mL/kg bw, respecitively. All high dose animals died, while all low dose
animals survived. Erythema, edema and necrosis of the skin at the site
of contact was observed, with congestion and hemorrhage of the lungs of
the animals that died. The LD50 was determined to be 7.13 mL/kg bw,
which corresponds to 5583 mg/kg bw.
Based on the available information
classification for acute oral, inhalation or dermal toxicity is not
warranted in accordance with EU Classification, Labeling and Packaging
of Substances and Mixtures (CLP) Regulation No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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