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Toxicological information

Exposure related observations in humans: other data

Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Reference
Reference Type:
secondary source
Title:
SIDS Initial Assessment report for SIAM 5: Isobutanal CAS No: 78-84-2
Author:
OECD SIDS
Year:
2004

Materials and methods

Type of study / information:
Effects after exposure of male volunteers
Endpoint addressed:
respiratory irritation
Principles of method if other than guideline:
15 male volunteers exposed to 210 ppm vapour for 30 min
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Isobutyraldehyde
EC Number:
201-149-6
EC Name:
Isobutyraldehyde
Cas Number:
78-84-2
Molecular formula:
C4H8O
IUPAC Name:
2-methylpropanal
Details on test material:
- Name of test material: Isobutanal

Method

Ethical approval:
not specified
Exposure assessment:
not specified
Details on exposure:
15 male volunteers were exposed to 210 ppm (620 mg/m3) isobutanal vapour for 30 min

Results and discussion

Results:
No irritation was observed. Nausea was noted by some of the subjects, and one subject vomited.

Applicant's summary and conclusion

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