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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Qualifier:
according to guideline
Guideline:
EU Method C.2 (Acute Toxicity for Daphnia)
GLP compliance:
no
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
Daphnia magna
Details on test organisms:
- Age of test organisms: 2-24 h
- Source: Institut National de Recherche Chimique Appliquee, France
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
48 h
Hardness:
total hardness 2.98 mmol/L
Test temperature:
292-294 K
pH:
7.54 - 8.05
Dissolved oxygen:
7.77 - 8.93 mg/L
Nominal and measured concentrations:
Nominal concentrations: 0, 31.25, 62.5, 125, 250 and 500 mg/L
Details on test conditions:
- Test was performed in non-sealed beakers
- Test volume: 10 mL
- No. test organisms: 5
- No. of replicates: 4
Key result
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
277 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Remarks on result:
other: 236.81-324.92 mg/L
Details on results:
OTHER REPORTED EFFECT CONCENTRATIONS:
48-h EC100: 500 mg/L
48-h EC0: 125 mg/L
24-h EC100: 500 mg/L
24-h EC50: 308 mg/L
24-h EC0: 125 mg/L

Description of key information

The 48-h EC50 value is 277 mg/L in aquatic invertebrates (D. magna).

Key value for chemical safety assessment

Additional information

The acute toxicity to aquatic invertebrates was determined in a study according to Directive 79/831/EEC, Annex V, Part C. In this study daphnids (D. magna, 20 per concentration) were exposed to nominal concentrations of 0, 31.25, 62.5, 125, 250 and 500 mg/L for 48 hours under static conditions. Immobilization was recorded after 24 and 48 hours exposure. At a test concentration of 125 and 500 mg/L cumulative mortality was 0% and 100%, respectively. Based on these findings the 48-h EC50 value was determined at 277 mg/L.

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