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EC number: 227-006-8 | CAS number: 5593-70-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- October 3, 1984 - November 16, 1984
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study pre-dates GLP and performed according to a non-guideline method. Insufficient data is provided on study methods and results. However, the test material contained only 25 % titanium tetrabutanolate. The main component of the test material was kerosene (75 %).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test material was evaluated for primary skin irritation potential in male and female rabbits. Prior treatment, the dorsal area of each rabbit was clipped free of hair. 0,5ml aliquot of the test material was applied under a one by one square gauze patch which was secured in place with adhesive tape. The trunk of each rabbit was wrapped with impervious rubber damming and the rabbits were then immobilized in stocks for 24hours. Twenty-four hours following application, the test substance was removed and the exposure sites were wiped with propylene glycol. Dermal responses were graded and scored at 24. 48. 72 and 96 hours and 7 days.
- GLP compliance:
- no
Test material
- Reference substance name:
- Titanium tetrabutanolate
- EC Number:
- 227-006-8
- EC Name:
- Titanium tetrabutanolate
- Cas Number:
- 5593-70-4
- Molecular formula:
- C16H36O4Ti
- IUPAC Name:
- titanium(4+) tetrakis(butan-1-olate)
- Details on test material:
- - Name of test material (as cited in study report): 1-butanol, titanium (4+) Salt, Haskell No. 15,538
- Substance type:organometal
- Physical state: liquid
- Analytical purity: 95-100%
- Impurities (identity and concentrations): Possibly 1-butanol 0-5%
- Composition of test material, percentage of components: 25 % titanium tetrabutanolate, 75 % kerosene
- Storage condition of test material: at room temparature
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hazleton Dutchland. Inc., Denver, Pennsylvania
- Housing: individually in elevated wire-mesh cages
- Diet (e.g. ad libitum): commercial rabbit ration (Purina Lab Rabbit Chow #5321) ad libitum except during 24 hours immobilization period
- Water (e.g. ad libitum): tap water ad libitum except during 24 hours immobilization period
- Acclimation period: minimum of seven days
After observation period of 7 days all rabbits were sacrificed with T61 euthanasia solution and discarded without necropsy
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0,5ml
- Concentration (if solution): 100% - Duration of treatment / exposure:
- 24 hours
- Observation period:
- At 24, 48, 72 and 96 hours and 7 days after test material application the skin responses were recorded
- Number of animals:
- 6
- Details on study design:
- TEST SITE
The dorsal area of each rabbit was clipped free of hair. Test material was applied under a one by one square gauze patch which was secured in place with adhesive tape. The trunk of each rabbit was wrapped with impervious rubber damming and the rabbits were then immobilized in stocks for 24hours.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): exposure sites were wiped with propylene glycol
- Time after start of exposure: 24h
SCORING SYSTEM:
Draize scale for scoring primary skin irritation
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 1.7
- Max. score:
- 4
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 1.7
- Max. score:
- 4
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 1.7
- Max. score:
- 4
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1.3
- Max. score:
- 4
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1.7
- Max. score:
- 4
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1.3
- Max. score:
- 4
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 1.3
- Max. score:
- 4
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 2.3
- Max. score:
- 4
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.74
- Reversibility:
- not reversible
- Remarks on result:
- other: Skin blanching, thickening, fissuring and necrosis was observed
- Irritant / corrosive response data:
- Titanium tetrabutanolate produced well-defined erythema (Grade 2) in five animals and moderate to severe erythema (Grade 3) in one animal at 24 hours. Well-defined erythema (Grade2) was noted also in five animals at 48 hours, in all animals at 72 hours, and in only one animal at 96 hours. Very slight erythema (Grade 1) was noted in one animal at 48 hours and in five animals at 96 hours. Moderate to severe edema (Grades 3 or 4) was noted in all animals at 24 hours, subsiding to very slight edema in all animals at 48 hours and in three animals at 72 hours. Other dermal effects noted during this study were skin blanching, thickening, fissuring, and necrosis. No mortality occurred during the study.
- Other effects:
- Animal Other dermal effects
Number Sex 24h 48h 72h 96h 7d
E36661 M B BT TN N N
E36662 M B BT BT N N
E36663 M B BTF TN N N
E36702 F B BTF BTF TNF N
E36103 F B BTF BTF NF NF
E36704 F B TF BTF N N
B-Blanching
T-Thickening
F-Fissuring
N-Necrosis
Any other information on results incl. tables
Animal | Erythema score | Edema score | ||||||||||||
Number | Sex | 24h | 48h | 72h | 96h | 7d | avg 24/48/72 | 24h | 48h | 72h | 96h | 7d | avg 24/48/72 | |
E36661 | M | 2 | 2 | 2 | 1 | 0 | 2,0 | 3 | 1 | 0 | 0 | 0 | 1,3 | |
E36662 | M | 2 | 2 | 2 | 1 | 0 | 2,0 | 3 | 1 | 1 | 0 | 0 | 1,7 | |
E36663 | M | 2 | 2 | 2 | 1 | 0 | 2,0 | 3 | 1 | 0 | 0 | 0 | 1,3 | |
E36702 | F | 2 | 2 | 2 | 2 | 0 | 2,0 | 4 | 1 | 0 | 0 | 0 | 1,7 | |
E36103 | F | 3 | 2 | 2 | 1 | 0 | 2,3 | 3 | 1 | 1 | 0 | 0 | 1,7 | |
E36704 | F | 1 | 1 | 2 | 1 | 0 | 1,3 | 3 | 1 | 1 | 0 | 0 | 1,7 |
Applicant's summary and conclusion
- Interpretation of results:
- highly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The primary dermal irritation/corrosion potential of the test substane (25 % titanium tetrabutanolate, 75 % kerosene) was evaluated when applied to the skin of rabbits for 24 hour. By the study report, the test substance is considered to be severely irritating.
- Executive summary:
This study was regarded not reliable, since the study pre-dates GLP and performed according to a non-guideline method. Insufficient data is provided on study methods and results. By the study report, the test substance is severe skin irritant.
The result of this study cannot be used to evaluate the skin irritation of titanium tetrabutanolate, since the composition of the tested material was 25 % titanium tetrabutanolate and 75% kerosene. Thus, the result is used as a weight of evidence in hazard assessment.
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