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EC number: 240-985-6 | CAS number: 16923-95-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1996-12-09 to 1996-12-10
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study reliable with restrictions - the stability was missing in the study report.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- 1987-02-24
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- signed 1996-02-27
Test material
- Reference substance name:
- Dipotassium hexafluorozirconate
- EC Number:
- 240-985-6
- EC Name:
- Dipotassium hexafluorozirconate
- Cas Number:
- 16923-95-8
- Molecular formula:
- F6Zr.2K
- IUPAC Name:
- dipotassium hexafluorozirconate
- Details on test material:
- - Name of test material (as cited in study report): POTASSIUM HEXAFLUOROZIRCONATE
- Physical state: white crystalline solid
- Storage condition of test material: ambient temperature (<25°C), stored under artificial light
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Age at study initiation: twelve to sixteen weeks old
- Weight at study initiation: 2.70 kg
- Housing: the animal was housed in a suspended metal cage.
- Diet (ad libitum): STANRAB SQC Rabbit Diet, Special Diets Services, Witham, Essex, UK
- Water (ad libitum): mains drinking water
- Acclimation period: at least five days
ENVIRONMENTAL CONDITIONS
- Temperature: 18 to 19°C
- Relative humidity: 49 to 56%
- Air exchanges: approximately fifteen changes per hour
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): a volume of 0.06 mL of the test material, which was found to weigh approximately 100 mg (as measured by gently compacting the required volume into an adapted syringe) was placed into the conjunctival sac of the right eye, formed by gently pulling the lower lid away from the eyeball. The upper and lower eyelids were held together for about one second immediately after application, to prevent loss of the test material, and then released. The left eye remained untreated and was used for control purposes. - Duration of treatment / exposure:
- not applicable
- Observation period (in vivo):
- approximately 1 and 24 hours following treatment
- Number of animals or in vitro replicates:
- one male rabbit
- Details on study design:
- Immediately before the start of the test, both eyes of the provisionally selected test rabbit were examined for evidence of ocular irritation or defect with the aid of a light source from as standard ophthalmoscope.
SCORING SYSTEM: according to the Draize scale
Any other ocular effects were also recorded.
Immediately after administration of the test material, an assessment of the initial pain reaction was made.
If the rabbit shows irreversible ocular damage the test material will be classified as corrosive to the eye.
TOOL USED TO ASSESS SCORE: examination of the eye was facilitated by the use of the light source from a standard ophthalmoscope.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: 1 hour
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: Opacity of cornea covered an area greater than three quarters, up to whole area.
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: 24 hour
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: Due to showing signs of pain and discomfort (i.e. holding head to one side and abnormally quiet) the animal was killed for humane reasons after the 24-hour observation. Opacity of cornea covered an area greater than three quarters, up to whole area.
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: 1 hour
- Score:
- 1
- Max. score:
- 2
- Reversibility:
- not reversible
- Remarks on result:
- other: Pupil abnormally small in appearance.
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: 24 hour
- Score:
- 1
- Max. score:
- 2
- Reversibility:
- not reversible
- Remarks on result:
- other: Due to showing signs of pain and discomfort (i.e. holding head to one side and abnormally quiet) the animal was killed for humane reasons after the 24-hour observation. Pupil abnormally small in appearance.
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 1 hour
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- not reversible
- Remarks on result:
- other: Petechial haemorrhage of nictitating membrane.
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 24 hour
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not reversible
- Remarks on result:
- other: Due to showing signs of pain and discomfort (i.e. holding head to one side and abnormally quiet) the animal was killed for humane reasons after the 24-hour observation. Haemorrhage of conjunctival membranes; pale appearance of nictitating membrane.
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- other: 1 hour
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: Discharge with moistening of the lids and hairs a considerable area around the eye.
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- other: 24 hour
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: Due to showing signs of pain and discomfort (i.e. holding head to one side and abnormally quiet) the animal was killed for humane reasons after the 24-hour observation. Discharge with moistening of the lids and hairs a considerable area around the eye.
- Irritant / corrosive response data:
- Diffuse corneal opacity was noted in the treated eye one hour after treatment with translucent corneal opacity noted at the 24-hour observation. Iridial inflammation was noted in the treated eye one hour after treatment and at the 24-hour observation.
Moderate conjunctival irritation was noted in the treated eye one hour after treatment with severe conjunctival irritation at the 24-hour observation.
Petechial haemorrhage of the nictitating membrane was noted in the treated eye one hour after treatment. Haemorrhage of the nictitating membrane and conjunctival membranes of upper and lower eyelids was noted at the 24-hour observation. The nictitating membrane appeared pale and the pupil abnormally small at this time.
Due to showing signs of pain and discomfort (i.e. holding head to one side and abnormally quiet) the animal was killed for humane reasons after the 24-hour observation, in accordance with company policy and current UK Home Office guidelines.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test material is considered to cause serious damage to the eyes of rabbits.
According to 67/548/EC and subsequent regulations, dipotassium hexafluorozironate is classified as being a risk of causing serious damage to the eyes (R41).
According to the EC Regulation No. 1272/2008 and subsequent regulations, dipotassium hexafluorozironate is classified as Category 1.
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