Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets generally accepted scientific standards, well documented and acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981
Report Date:
1981

Materials and methods

Principles of method if other than guideline:
Concentrated vapour inhalation consists of subjecting 12 rats to a flowing stream of vapor-ladened air for a total of 7 hours.
GLP compliance:
no
Test type:
other: Inhalation-risk-test

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): N-(2-Ethylhexyl)-2-napthalinamin
- Physical state: liquid

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals and environmental conditions:
TEST ANIMALS
- Weight at study initiation: mean weight males: 203 g (1st experiment) 220 g (2nd), mean weight females: 179 g (1st), 188 g (2nd)



ENVIRONMENTAL CONDITIONS
no data

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
other: no data
Details on inhalation exposure:
no data
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
7 h
Concentrations:
according to raw data ca. 0.11 mg/l
No. of animals per sex per dose:
6 (3/sex/dose first experiment, 3/sex/dose 2nd experiment)
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Statistics:
no data

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 11 mg/L air
Exp. duration:
7 h
Remarks on result:
other: concentrated vapour-air mixture
Mortality:
No mortalities occured after exposing 12 rats for 7 hours to vapor-air mixture
Clinical signs:
other: none
Body weight:
no data
Gross pathology:
no findings

Applicant's summary and conclusion