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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Read-across to strontium chromate. OECD Guideline study.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2001
Report date:
2001

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
Strontium chromate
EC Number:
232-142-6
EC Name:
Strontium chromate
Cas Number:
7789-06-2
Molecular formula:
CrH2O4.Sr
IUPAC Name:
Strontium chromate
Details on test material:
- Name of test material (as cited in study report): L203E Chromate de strontium
- Molecular formula (if other than submission substance): SrCrO4
- Molecular weight (if other than submission substance): 203,62
- Substance type: powder
- Physical state: solid
- Analytical purity: 95%
- Impurities (identity and concentrations): 2.6% BaCrO4
- Composition of test material, percentage of components: CrO3: 47.70%; Sro: 49.40%
- Purity test date: no data
- Lot/batch No.: 019031
- Expiration date of the lot/batch: no data
- Stability under test conditions: no data
- Storage condition of test material: room temperature, protected from humidity
- Other: pH in purified water 7-8

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: CEGAV, Saint Mars d'Egrenne, France
- Age at study initiation: no data
- Weight at study initiation: 2.3 ± 0.1 kg
- Housing: indicidually in polystyrene cages
- Diet (e.g. ad libitum): free access to 110 pelleted diet (UAR, Villemoisson, Epinay-sur-Orge, France)
- Water (e.g. ad libitum): Micropore filtered water ad libitum
- Acclimation period: no data

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18 ± 3 °C
- Humidity (%): 30-70%
- Air changes (per hr): 12 cycles/h, filtered, non-recycled air
- Photoperiod (hrs dark / hrs light): 12 h

Test system

Type of coverage:
semiocclusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
not required
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 500 mg
Duration of treatment / exposure:
3 minutes on left flank and 4 hours on right flank.
Observation period:
1, 24, 48, 72 h after removal of the dressing. In absence of irritation, the study was ended on day 4.
Number of animals:
3
Details on study design:
TEST SITE
- Area of exposure: no data
- % coverage: no data
- Type of wrap if used: semi-occlusive dressing

REMOVAL OF TEST SUBSTANCE
- Washing (if done): no


SCORING SYSTEM:
erythema and eschar formation: scoring scale 0-4
oedema formation: scoring scale 0-4

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24 h, 48 h, 72 h
Score:
0
Max. score:
4
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24 h, 48 h, 72 h
Score:
0
Max. score:
4
Irritant / corrosive response data:
No signs of irritation.
Other effects:
Yellow coloration of the skin.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: OECD GHS
Conclusions:
Strontium is not irritating when applied topically on rabbits according to a standard test method.
Executive summary:

Skin irritation/corrosion of strontium chromate was tested on rabbits using a standard test protocol (OECD 404). The results showed no signs of irritation, and strontium chromate can therefore be classified as non-irritant.