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EC number: 701-349-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 July 2017 - 01 June 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Study was conducted in accordance with international guidelines and in accordance with GLP. All guideline validity criteria were met.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- Regulation (EC) 440/2008 of 30 May 2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 27 July 1995
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 4.8 mg/L
- Conc. based on:
- test mat.
- Remarks:
- Total Organic Carbon
- Temp.:
- 20 °C
- pH:
- >= 6.6 - <= 7.6
- Remarks on result:
- other: Mean value
- Remarks:
- Samples 1 - 3 and sample 6
- Conclusions:
- The water solubility of the test item (as total dissolved carbon) has been determined to be 4.8 x 10-3 g/L at 20.0 ± 0.5 °C.
- Executive summary:
EU Method A.6. – The water solubility of the test item was determined using the shake flask method. The procedure employed was designed to be compatible with Method A.6., water solubility, of Commission Regulation (EC) No 440/2008 of 30 May 2008.
Follow the outcome of a preliminary test, seven samples were prepared for a main test at nominal loading rates of 0.1 – 50 g/L. After preparation, the samples were shaken (200 rpm) at 30.0 ± 1.0 °C followed by static equilibration at 20.0 ± 0.5 °C for a period of 24 – 72 hours. The solutions were centrifuged at 13,000 rpm for 15 minutes, filtered through 0.2 µm filters and analysed. The pH of each solution was measured. The concentration of organic carbon dissolved in each sample solution was determined by total organic carbon (TOC) analysis.
During the main test increasing test item concentrations (as TOC) were demonstrated with increasing loading rate. The effect of loading rate was observed from a nominal loading rate of 10 g/L and above. At nominal loading rates at 1 g/L and below, there was no significant effect of loading. It is considered that the water solubility of the test item should be reported as the mean of the values where the loading rate was observed to have no significant effect (loading rates 0.1 to 1 g/L. The mean water solubility of the test item (as total dissolved carbon) has been determined to be 4.8 x 10-3 g/L at 20.0 ± 0.5 °C.
Reference
Evaluation of Data:
The TC and IC concentrations of each sample were measured and calculated automatically by the instrument’s software from plots generated during calibration. The TOC concentration was then calculated by subtraction of the IC concentration from the TC concentration.
Results – Preliminary Test:
The concentration (mg/L) of test item (as total organic carbon) in the sample solutions is shown in Table 4:
Table 4: Preliminary Test Results
Sample Number |
Nominal loading rate (g/L) |
Time shaken at ~ 30 ºC (hrs) |
Concentration (mg TOC/L) |
Time Shaken at 30 ºC (h) |
A |
0.1 |
4.5 |
7.9 |
6.5 |
B |
1 |
4.5 |
7.8 |
6.5 |
C |
10 |
4.5 |
13.7 |
6.8 |
Results – Definitive Test:
The concentration (mg/L) of test item (as total organic carbon) in the sample solutions is shown in Table 5:
Table 5: Definitive Test Results
Sample Number |
Nominal loading rate (g/L) |
Time shaken at ~ 30 ºC (hrs) |
Concentration (mg TOC/L) |
Time Shaken at 30 ºC (h) |
Blank |
- |
- |
<1 |
- |
1 |
0.1 |
72 |
4.6 |
6.6 |
2 |
0.5 |
72 |
4.7 |
6.6 |
3 |
1 |
72 |
5.6 |
6.5 |
4 |
10 |
72 |
10.5 |
6.8 |
5 |
50 |
72 |
30.5 |
7.6 |
6 |
1 |
48 |
4.2 |
7.3 |
7* |
1 |
24 |
47.0 |
7.5 |
* Sample 7 considered to be an outlier. Sample most likely contaminated during sample preparation. The result has not used in calculations.
The concentrations have not been corrected for the blank contribution as this was less than the limit of quantification of the instrument and therefore is quoted as a limit value.
Concentrations for loading rates tested were found to be in the range of 4.2 to 30.5 mg TOC/L at 20.0 ± 0.5 ºC. Increasing test item concentrations (as TOC) were demonstrated with increasing loading rate. The effect of loading rate was observed from a nominal loading rate of 10 g/L and above.
At nominal loading rates at 1 g/L and below, there was no significant effect of loading. It is considered that the water solubility of the test item should be reported as the mean of the values where the loading rate was observed to have no significant effect (loading rates 0.1 to 1 g/L, Samples 1, 2, 3 and 6).
Overall Result: 4.8 x 10-3g/L at 20.0 °C
Discussion:
As the test item was a complex mixture, the flask shaking test was performed. On completion of the equilibration period, the samples were clear, colourless solutions with excess test item present. After the sample solutions had been centrifuged and filtered, the solutions were observed to be clear, colourless solutions.
Description of key information
Water Solubility: 4.8 x 10-3 g/L at 20.0 ± 0.5 °C; EU Method A.6.; R. Butler (2018).
Key value for chemical safety assessment
- Water solubility:
- 0.005 g/L
- at the temperature of:
- 20 °C
Additional information
EU Method A.6. – The water solubility of the test item was determined using the shake flask method. The procedure employed was designed to be compatible with Method A.6., water solubility, of Commission Regulation (EC) No 440/2008 of 30 May 2008.
Follow the outcome of a preliminary test, seven samples were prepared for a main test at nominal loading rates of 0.1 – 50 g/L. After preparation, the samples were shaken (200 rpm) at 30.0 ± 1.0 °C followed by static equilibration at 20.0 ± 0.5 °C for a period of 24 – 72 hours. The solutions were centrifuged at 13,000 rpm for 15 minutes, filtered through 0.2 µm filters and analysed. The pH of each solution was measured. The concentration of organic carbon dissolved in each sample solution was determined by total organic carbon (TOC) analysis.
During the main test increasing test item concentrations (as TOC) were demonstrated with increasing loading rate. The effect of loading rate was observed from a nominal loading rate of 10 g/L and above. At nominal loading rates at 1 g/L and below, there was no significant effect of loading. It is considered that the water solubility of the test item should be reported as the mean of the values where the loading rate was observed to have no significant effect (loading rates 0.1 to 1 g/L. The mean water solubility of the test item (as total dissolved carbon) has been determined to be 4.8 x 10-3 g/L at 20.0 ± 0.5 °C.
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