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Diss Factsheets
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EC number: 947-697-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute toxicity, oral in rats: LD50 = 1850 mg/kg bw (equivalent or similar to OECD 401, K, Rel. 2)
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- Some housing conditions are not reported (temperature, humidity, air changes); lack of details on the test item; no (historical) control group
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Specific details on test material used for the study:
- Name in the study report: origanium oil
Test article label: 72-206 - Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- No data
- Doses:
- 1.32, 2.02, 3.2 and 5 g/kg bw
- No. of animals per sex per dose:
- 10/dose
- Control animals:
- no
- Details on study design:
- Animals were observed for 14 days.
- Preliminary study:
- Not applicable
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 850 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 1 500 - < 2 200
- Mortality:
- See table below
- Clinical signs:
- piloerection and lethargy
- Other findings:
- None
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Under the test conditions, the oral LD50 of the test substance was determined to be 1850 mg/kg bw therefore it is classified as category 4 (H302) according to the Regulation (EC) N° 1272-2008 and GHS.
- Executive summary:
In an acute oral toxicity study performed similarly to OECD guideline 401, single oral dose of 1320, 2020, 3200 or 5000 mg/kg bw of the undiluted test substance was administered to 10 rats/dose. Animals were then observed for mortality and clinical signs of toxicity for 14 days.
1/10, 6/10, 9/10 and 10/10 animals died at 1320, 2020, 3200 and 5000 mg/kg bw, respectively with signs of piloerection and lethargy.
Under the test conditions, the oral LD50 of the test substance was determined to be 1850 mg/kg bw therefore it is classified as category 4 (H302) according to the Regulation (EC) N° 1272-2008 and GHS.
Reference
Distribution of mortality:
Dose (g/kg) |
Total deaths |
Day 1 |
Day 2 |
Day 3 |
Day 4 |
Day 5 |
Day 6 |
Day 7 and thereafter |
1.32 |
1/10 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
2.02 |
6/10 |
5 |
0 |
0 |
0 |
1 |
0 |
0 |
3.2 |
9/10 |
4 |
3 |
2 |
0 |
0 |
0 |
0 |
5 |
10/10 |
6 |
2 |
1 |
0 |
0 |
1 |
0 |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 850 mg/kg bw
- Quality of whole database:
- Adequate for hazard assessment
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Acute toxicity: via oral route
In an acute oral toxicity study performed similarly to OECD guideline 401, single oral dose of 1320, 2020, 3200 or 5000 mg/kg bw of the undiluted test substancewas administered to 10 rats/dose. Animals were then observed for mortality and clinical signs of toxicity for 14 days.
1/10, 6/10, 9/10 and 10/10 animals died at 1320, 2020, 3200 and 5000 mg/kg bw, respectively with signs of piloerection and lethargy.
Under the test conditions, the oral LD50 of the test substance was determined to be 1850 mg/kg bw therefore it is classified as category 4 (H302) according to the Regulation (EC) N° 1272-2008 and GHS.
Justification for classification or non-classification
Harmonized classification:
The registered substance has no harmonized classification according to the Regulation (EC) No. 1272/2008.
Self-classification:
Acute toxicity via Oral route:
Based on the available information, the registered substance is:
- classified as category 4 (H302) according to the Regulation (EC) No. 1272/2008 and GHS.
Acute toxicity via Dermal route:
Based on the available information, the registered substance is:
- not classified according to Regulation (EC) No. 1272/2008 and potentially classified as category 5 according to GHS.
Acute toxicity via Inhalation: This information is not available.
Specific target organ toxicity: single exposure (Oral):
The classification criteria according to the Annex VI of the Regulation (EC) No. 1272/2008 as specific target organ toxicant (STOT) – single exposure, oral are not met since no reversible or irreversible adverse health effects were observed immediately or delayed after exposure and no effects were observed at the guidance value (oral) for a Category 1 classification (C ≤ 300 mg/kg bw) and at the guidance value (oral) for a Category 2 classification (2000 mg/kg bw ≥ C > 300 mg/kg bw). No classification is required.
Specific target organ toxicity: single exposure (Dermal):
The classification criteria according to the Annex VI of the Regulation (EC) No. 1272/2008 as specific target organ toxicant (STOT) – single exposure, oral are not met since no reversible or irreversible adverse health effects were observed immediately or delayed after exposure and no effects were observed at the guidance value (oral) for a Category 1 classification (C ≤ 300 mg/kg bw) and at the guidance value (oral) for a Category 2 classification (2000 mg/kg bw ≥ C > 300 mg/kg bw). No classification is required.
Specific target organ toxicity: single exposure (Inhalation): This information is not available.
Based on its composition (> 10% of aspiration toxicants or hydrocarbons), the registered substance is classified for aspiration hazard category 1, H304 according to CLP Regulation and GHS.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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