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Diss Factsheets
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EC number: 946-364-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2015-04-01 - 2015-04-15
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- The Department of Health of the Government of the United Kingdom
Test material
- Reference substance name:
- Reaction product of D-Glucopyranoside, methyl; esterified with oleic acid, methyl ester
- EC Number:
- 946-364-2
- Molecular formula:
- C43H78O8
- IUPAC Name:
- Reaction product of D-Glucopyranoside, methyl; esterified with oleic acid, methyl ester
- Test material form:
- liquid
- Details on test material:
- - State of aggregation: yellow liquid
-Others: storage at room temperature, in the dark
Constituent 1
Study design
- Details on sampling:
- Not applicable
- Buffers:
- Not applicable
- Estimation method (if used):
- Not applicable
- Details on test conditions:
- Not applicable
Results and discussion
- Preliminary study:
- Not applicable
Any other information on results incl. tables
Testing was not carried out using Method C7 Abiotic Degradation, Hydrolysis as a Function of pH of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 111 of the OECD Guidelines for Testing of Chemicals, 13 April 2004 for the following reasons:
• The test item as a whole was expected to be essentially insoluble in water. Therefore, the test solution concentration required, which would need to be less than half the water solubility, that would dissolve all the components, would be impractically low in order to perform the test. Also, a sufficiently sensitive analytical method was not available. Overall, these issues would make hydrolysis testing unfeasible.
• The test item is a complex mixture which the test method is not ideally suited to because each component that is unstable is likely to have its own hydrolytic rate. Also, if hydrolysis occurred many components would by hydrolyzed into the same structure as other components already present within the test item. It would then not be possible to distinguish between the original components and the hydrolysis product. The main functional groups within the components of the test item were ethers and esters. Ethers do not usually hydrolyze within environmentally relevant pH and temperature. Although esters can hydrolyze, especially in alkaline conditions, the test item components are considered to have a significantly reduced hydrolytic rate due to them being essentially insoluble in water. This is especially the case with the larger products that would be highly hydrophobic. The smaller products may be more susceptible to hydrolysis as they would have the potential to emulsify in water.
Applicant's summary and conclusion
- Conclusions:
- Method technically not feasible
- Executive summary:
Testing was not carried out using Method C7 Abiotic Degradation, Hydrolysis as a Function of pH of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 111 of the OECD Guidelines for Testing of Chemicals, 13 April 2004 for the following reasons:
• The test item as a whole was expected to be essentially insoluble in water. Therefore, the test solution concentration required, which would need to be less than half the water solubility, that would dissolve all the components, would be impractically low in order to perform the test. Also, a sufficiently sensitive analytical method was not available. Overall, these issues would make hydrolysis testing unfeasible.
• The test item is a complex mixture which the test method is not ideally suited to because each component that is unstable is likely to have its own hydrolytic rate. Also, if hydrolysis occurred many components would by hydrolyzed into the same structure as other components already present within the test item. It would then not be possible to distinguish between the original components and the hydrolysis product. The main functional groups within the components of the test item were ethers and esters. Ethers do not usually hydrolyze within environmentally relevant pH and temperature. Although esters can hydrolyze, especially in alkaline conditions, the test item components are considered to have a significantly reduced hydrolytic rate due to them being essentially insoluble in water. This is especially the case with the larger products that would be highly hydrophobic. The smaller products may be more susceptible to hydrolysis as they would have the potential to emulsify in water.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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