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EC number: 939-401-9 | CAS number: 1469983-41-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral (OECDTG420): LD50 >2000 mg/kg bw
Acute dermal (OECDTG402): LD50 >2000 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- > 2 000 mg/kg bw
- Quality of whole database:
- The study has klimisch code 1.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- > 2 000 mg/kg bw
- Quality of whole database:
- The study has klimisch code 1.
Additional information
Executive summaries of the studies performed with the source substance:
This study was performed to assess the acute oral toxicity of P-2290 to the rat. The method followed was that described in: EEC Methods for the determination of toxicity, Annex to Directive 92/69EEC (OJ No. L383A, 29.12.92), Part B, Method B. 1 bis. Acute toxicity (oral) - fixed dose method. OECD Guideline for Testing of Chemicals No.420 'Acute Oral Toxicity - Fixed Dose Method' Adopted 17 July 1992. A group of ten fasted rats (five males and five females) was given a single dose by oral gavage of the test substance, as supplied by the Sponsor, at a dose level of 2000 mg/kg bodyweight. This dose level was chosen after review of results from a sighting study. All animals were killed and examined macroscopically on Day 15, the end of the observation period. There were no deaths. Clinical signs of reaction to treatment were confined to piloerection, hunched posture and waddlingiunsteady gait, seen in all rat. In addition, abnormal faeces and ungroomed appearance were less commonly observed. Recovery of rats was complete in all instances by Day 2. All rats were considered to have achieved satisfactory bodyweight gains throughout the study. Macroscopic examination of animals killed at study termination on Day 15 revealed no abnormalities. The LD50 is > 2000 mg/kg bw.
A study was performed to assess the acute dermal toxicity of P-2290 to the rat. The method followed was that described in: EEC Methods for the determination of toxicity, Annex to Directive 92/69/EEC (OJ No. L383A7 29.12.92), Part B, Method B.3. Acute toxicity (dermal). OECD Guideline for Testing of Chemicals No. 402 "Acute Dermal Toxicity". Adopted: 24 February 1987.
A group of ten rats (five males and five females) received a single topical application of the test substance, administered as supplied at a dose level of 2000 mg/kg bodyweight. All animals were killed and examined macroscopically on Day 15, the end of the observation period. There was no systemic response in any animal throughout the study. Slight to well-defined dermal irritation was noted in three animals, resolving in all instances by Day 7.
No dermal response to treatment was recorded for any other animal throughout the study.A slightly low bodyweight gain was recorded for one female on Day 8, with a similar trend noted for one further female on Day 15. All other animals were considered to have achieved satisfactory bodyweight gains throughout the study. No abnormalities were recorded at the macroscopic examination on Day 15. The acute lethal dermal dose to rats of P-2290 was demonstrated to be greater than 2000 mg/kg bodyweight.
Justification for classification or non-classification
Based on the available information, the substance does not have to be classified and has no obligatory labelling requirement for acute oral, acute inhalation and acute dermal toxicity according to Regulation (EC) No 1272/2008 and its amendments.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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