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EC number: 932-284-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Alchisor TAL 145 can be characterised according to three constituents: Hydrocarbons C11-C14, n-alkanes, isoalkanes, cyclics, aromatics (2-25%), dodecan-1-ol and tetradecan-1-ol. As defined in the Read-Across Justification Document in section 13, data provided for these constituents when considered together is representative of Alchisor TAL 145 and suitable for assessment purposes. Study data for each constituent has been evaluated and considered together. In a protective approach the most sensitive study results from across the three constituents has been identified and used to address the endpoint in question.
As detailed in Table 1 below, 4 skin sensitisation study reports are available for constituents of Alchisor TAL 145. Adequate reliable data is available for each constituent. Therefore using our protective approach the dataset is a reliable adequate basis for Alchisor TAL 145 assessment purposes.
Table 1: Sensitisation Key/Supporting Studies for Constituents of Alchisor TAL 145
Constituents of Alchisor TAL 145
Reference
Hydrocarbons C11 -C14, n-alkanes, isoalkanes, cyclics, aromatics (2 -25%)
Dodecan-1-ol
Tetradecan-1-ol
Ilhama 1997
Key
Opdyke 1975
Supporting
Coombs 1977
Key
Lihama 1997
Key
In a reliable GLP compliant OECD 406 study the skin sensitising potential of Kalcol 4098 (tetradecan-1-ol) was assessed. There was no evidence of any sensitising potential and so tetradecan-1-ol was determined to be non-sensitising. This non-sensitising potential was confirmed in a further supporting study (Klimisch 4) whereby 50 human volunteers were exposed to tetradecan-1-ol in a petrolatum vehicle.
The sensitization potential of dilutine M5 (identified as hydrocarbons, C9-C12, n-alkanes, isoalkanes, cyclics, aromatics (2-25%)) was assessed in a guinea pig maximization test (Coombs 1997). Intradermal induction of the test item at 0.1 % w/v in corn oil was followed by a topical induction of 50% w/v in corn oil and a challenge of 25.0% w/v in corn oil. No skin response was reported in any of the test animals (10/sex) and so the test item was deemed non-sensitizing. This finding is further confirmed by a dermal sensitisation study in humans (ExxonMobil 1962). 101 volunteers (age 19-62) were exposed to test compounds (representing C9-C14 aliphatics (2-25% aromatics)) for 4-6 hours. Following the initial patch the test materials were to the subjects¿ forearms once or twice daily, five days a week, for three weeks. None of the test materials were found to be skin sensitizers.
Dodecan-1-ol was assessed for sensitization potential according to OECD 406 in a guinea pig maximisation test (Iihama 1997). In this reliable (Klimisch 1) and GLP compliant study dodecan-1-ol was reported not to be sensitising.
Migrated from Short description of key information:
Alchisor TAL 145 can be characterised according to three constituents: Hydrocarbons C11-C14, n-alkanes, isoalkanes, cyclics, aromatics (2-25%), dodecan-1-ol and tetradecan-1-ol.
Skin sensitisation study data for constituents of Alchisor TAL 145 indicate a lack of sensitisation. Consequently Alchisor TAL 145 is determined to be non-sensitising to skin.
Justification for classification or non-classification
The information presented in this dossier provides evidence that the constituents of Alchisor TAL 145 do not possess a skin sensitization potential. Consequently Alchisor TAL 145 does not require classification as a sensitiser as required by the current EU guideline.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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