reaction mass of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-2H -isothiazol-3-one

Density

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

relative density

Type of information:

experimental study

Adequacy of study:

key study

Study period:

6 Jan 2003 - 29 Sept 2003

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.3 (Relative Density)

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

GLP compliance:

yes

Type of method:

pycnometer method

Dynamic viscosity of test material:

The relative density was determined by a pyknometer method. The procedure conformed with EC Directive 92/69/EEC Method A3 and OECD Guideline 109. The following steps were performed with the test substance "as received", and following dilution with distilled water to contain nominally 1% of active ingredient.
A clean, dry pyknometer was weighed empty. It was filled with test substance to the top of the stopper capillary and re-weighed, then after emptying, cleaning and drying, this was repeated using distilled water. These steps were performed with the fluids which had been equilibrated to a test temperature of 20°C. The process was repeated a further three times.

Type:

relative density

Density:

1.294 g/cm³

Temp.:

20 °C

Remarks on result:

other: as received

Type:

relative density

Density:

1.015 g/cm³

Temp.:

20 °C

Remarks on result:

other: 1% dilution

The test temperature was 20.0°C. The density of water at this temperature (ρw) is 0.9982 g.cm-3.

Table 1. Determination of relative density (as received)

	Replicate
	1	2	3	4
Measurements
A Weight of pycnometer empty (g)	12.5346	11.0927	11.4971	11.2137
B Weight of pycnometer plus test substance (g)	25.7228	23.2012	23.7122	23.4993
C Weight of pycnometer plus water (g)	22.6991	20.4352	20.9085	20.6997
Calculations
D Test substance weight [=B-A] (g)	13.1882	12.1085	12.2151	12.2856
E Water weight [=C-A] (g)	10.1645	9.3425	9.4114	9.4860
F Pyknometer volume [=E/pw] (ml)	10.1828	9.3593	9.4284	9.5031
G Test substance density [=D/F] (g/cm^3)	1.2951	1.2937	1.2956	1.2928

The mean density was 1.2943 g/cm³with a standard deviation (n-1) of 0.00128 (relative density (D4²⁰) = 1.294).

 

Table 1. Determination of relative density (1% dilution)

	Replicate
	1	2	3	4
Measurements
A Weight of pycnometer empty (g)	12.9333	10.7507	10.4932	12.5584
B Weight of pycnometer plus test substance (g)	23.0163	20.1855	20.2305	23.1108
C Weight of pycnometer plus water (g)	22.8118	20.0533	20.0694	22.9303
Calculations
D Test substance weight [=B-A] (g)	10.0830	9.4348	9.7373	10.5524
E Water weight [=C-A] (g)	9.8785	9.3026	9.5762	10.3719
F Pyknometer volume [=E/pw] (ml)	9.8963	9.3194	9.5935	10.3906
G Test substance density [=D/F] (g/cm^3)	1.0189	1.0124	1.0150	1.0156

The mean density was 1.01548 g/cm³with a standard deviation (n-1) of 0.00267 (relative density (D4²⁰) = 1.015).

Conclusions:

The relative density (D4^20 ) of Kathon 886 MW Biocide (as received) was determined by a bottle pyknometric method to be 1.294. Diluted in water to nominally 1% active ingredient content, the relative density was 1.015.

Executive summary:

The relative density (D4^20 ) of Kathon 886 MW Biocide (as received) was determined by a bottle pyknometric method to be 1.294. Diluted in water to nominally 1% active ingredient content, the relative density was 1.015.

Reference 2

Endpoint:

density

Remarks:

density

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Guideline-confrom study under GLP without deviations.

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.3 (Relative Density)

Version / remarks:

Cited as Directive 92/69/EEC, A.3

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

air comparison pycnometer (for solids)

Type:

density

Density:

1.6 g/cm³

Temp.:

20.8 °C

Conclusions:

The relative density of 5-chloro-2-methyl-3(2H)-isothiazolone was determined to be 1.60 (at 20.8°C).

Executive summary:

The relative densitiy of the test substance 5-chloro-2-methyl-3(2H)-isothiazolone was determined according to OECD guideline 109. A sample of the test compound was weighed, filled into a sample cell connected to a reference cell. The cells were separated, the reference cell filled with helium to overpressure, which was read. The cells were coupled, and the pressure read. The relative density was calculated from the resulting pressure and the weight of test substance sample.

Reference 3

Endpoint:

density

Remarks:

density

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Guideline-conform study under GLP without deviations.

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.3 (Relative Density)

Version / remarks:

Cited as Directive 92/69/EEC, A.3

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

air comparison pycnometer (for solids)

Type:

density

Density:

1.39 g/cm³

Temp.:

20 °C

Conclusions:

The relative density of 2-methyl-3(2H)-isothiazolone was determined to be 1.39 g/cm3 (at 20.0°C).

Executive summary:

The relative densitiy of the test substance 2-methyl-3(2H)-isothiazolone was determined according to OECD guideline 109. A sample of the test compound was weighed, filled into a sample cell connected to a reference cell. The cells were separated, the reference cell filled with helium to overpressure, which was read. The cells were coupled, and the pressure read. The relative density was calculated from the resulting pressure and the weight of test substance sample.

Key value for chemical safety assessment

Relative density at 20C:

1.256