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EC number: 620-174-7 | CAS number: 1079184-43-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Aug 16, 1985 - Sept 13, 1985
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- no analytical monitoring, 24 hr study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- yes
- Remarks:
- (24 h study, no analytical, dissolved oxygen measurements not provided)
- GLP compliance:
- yes
- Specific details on test material used for the study:
- - Substance type: quaternized ammonium compound
- Physical state: solid
- Storage condition of test material: ambient, isopropanol - Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- - Method: A stock solution was prepared by mxing an appropriate amount of test solution with dilution water; test solutions were prepared by dilution of the stock solution in dilution water.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Age at study initiation (mean and range, SD): 4-24 hr old
- Method of breeding: adults (at least 3 weeks old) seperated from stock population by sieving
- Feeding during test: not fed during test
ACCLIMATION
- Acclimation conditions (same as test or not): acclimated in dilution water (same as test)
- Type and amount of food: algal suspension (Scenedesmus subspicata)
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 24 h
- Hardness:
- 268.5 mg/L
- Test temperature:
- 18 - 22°C, for each single test constant within +/- 0.5 °C
- pH:
- 7.8 +/- 2.0
- Nominal and measured concentrations:
- Nominal: 0.1, 0.32, 1.0, 3.2, 10, 32 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Material, size, headspace, fill volume: 20 ml beaker
- Renewal rate of test solution (frequency/flow rate): 24 h static test (no renewal)
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: prepared according to test guideline DIN 348 12 L 11
- Ca/Mg ratio: 4:1
- Intervals of water quality measurement: 0 and 24 hrs
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : Immobilization at 24 h
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 3.2
- Range finding study
- Test concentrations: 0, 0.1, 1, 10, 100, 1000 mg/L
- Results used to determine the conditions for the definitive study: Yes - Reference substance (positive control):
- not specified
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 14.8 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- not specified
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% CL: 8.4 - 26.2
- Duration:
- 24 h
- Dose descriptor:
- EC0
- Effect conc.:
- 1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- not specified
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC100
- Effect conc.:
- > 32 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- not specified
- Basis for effect:
- mobility
- Details on results:
- - Effect concentrations exceeding solubility of substance in test medium: 32 mg/L (solubility <20 mg/L)
- Reported statistics and error estimates:
- LC50 or EC50, calculated according to Litchfield and Wilcoxon (1949).
- Validity criteria fulfilled:
- no
- Remarks:
- (dissolved oxygen concentrations not provided)
- Conclusions:
- The 24-hr acute toxicity of MDEA-Esterquat C16-18 and C18 unsatd. to Daphnia magna was investigated under static conditions in a study conducted according to OECD TG 202. The 24-h EC50 was determined to be 14.8 mg/L (nominal; 95% C.L.: 8.4 - 26.2 mg/L).
- Executive summary:
The 24-hr acute toxicity of MDEA-Esterquat C16-18 and C18 unsatd. to Daphnia magna was investigated under static conditions in a study conducted according to OECD TG 202 (Part I). Daphnids were exposed to 0, 0.1, 0.32, 1.0, 3.2, 10 and 32 mg/L (nominal) for 24 hours. Immobilisation was observed at test termination. The 24-h EC50 was 14.8 mg/L with 95% CL of 8.4 - 26.2 mg/L (nominal each). No other effects were noted. The study period of 24 h was recommended before adoption of the OECD Guideline 202 in 2004. Therefore this study does not meet the time criterium (study duration 24 h instead of 48 h) of today standard methods.
This study, however, is classified as reliable with restrictions and satisfies the guideline requirements for an acute toxicity study with freshwater invertebrates.
Reference
Table: Immobilisation of daphnids
Conc. [mg/L] |
Number of immobilized Daphnia |
% of 20 Daphnia immobilized |
control |
0 |
0 |
0.10 |
0 |
0 |
0.32 |
0 |
0 |
1.00 |
0 |
0 |
3.20 |
2 |
10 |
10.00 |
8 |
40 |
32.00 |
14 |
70 |
Description of key information
Daphnia magna: 24-h EC50=14.8 mg/L (nominal; 95% C.L.: 8.4 - 26.2 mg/L
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 14.8 mg/L
Additional information
The 24-hr acute toxicity of MDEA-Esterquat C16-18 and C18 unsatd. to Daphnia magna was investigated under static conditions in a study conducted according to OECD TG 202 (Part I). Daphnids were exposed to 0, 0.1, 0.32, 1.0, 3.2, 10 and 32 mg/L (nominal) for 24 hours. Immobilisation was observed at test termination. The 24-h EC50 was 14.8 mg/L with 95% CL of 8.4 - 26.2 mg/L (nominal each). No other effects were noted. The study period of 24 h was recommended before adoption of the OECD Guideline 202 in 2004. Therefore this study does not meet the time criterium (study duration 24 h instead of 48 h) of today standard methods.
Similar results were obtained with the closely related read-across substance MDIPA EsterquatC16-18 and C18 unsatd and MDIPA Esterquat C18 unsatd..:
The 48–hr-acute toxicity of MDIPA Esterquat C18 unsatd. to Daphnia magna was studied under semi-static conditions. Daphnids were exposed to control and test chemical at nominal concentrations of 0.10, 0.32, 1.0, 3.2, 10 mg/L, corresponding to measured (TWA) concentrations of 0.077, 0.27, 0.89, 2.8 and 8.6 mg/L in the presence of 4 mg/L humic acid for 48 h. Mortality/immobilisation and sublethal effects were observed daily.
The 48-hour EC50 was >8.6 mg/L (TWA) based on immobilisation.
The 48–hr-acute toxicity of MDIPA-Esterquat C16-18 and C18 unsatd. to Daphnia magna was studied under semi-static conditions. Daphnids were exposed to control and test chemical at analytically confirmed nominal concentrations of 0, 2.5, 4.5, 8.1, 14 and 25 mg/L in the presence of 4 mg/L (< 2mg/L DOC) humic acid for 48 h. Immobilisation was observed daily.
The 48-hour EC50 was 6.7 mg/L (analytically confirmed nominal concentration) based on immobilisation.
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